Endocytosis: a review of mechanisms and plasma membrane dynamics

Besterman, Jeffrey M.; Low, Robert B.

doi:10.1042/bj2100001

Cited by 188 publications

(75 citation statements)

References 162 publications

(113 reference statements)

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“…This does not explain, however, some discrepancies between azithromycin and chloroquine [45] or sucrose [67], which also cause extensive vacuolation of the late endocytic apparatus. In particular, azithromycin does not inhibit phagocytosis nor alter the accessibility of phagocytosed latex beads into lysosomes, in contrast with chloroquine [68,69], but similar to -COP-defective cells [70].…”

Section: Discussionmentioning

confidence: 80%

Azithromycin, a Lysosomotropic Antibiotic, Has Distinct Effects on Fluid-Phase and Receptor-Mediated Endocytosis, but Does Not Impair Phagocytosis in J774 Macrophages

Tyteca

Smissen²,

Mettlen

et al. 2002

Experimental Cell Research

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Section: Discussionmentioning

confidence: 80%

Azithromycin, a Lysosomotropic Antibiotic, Has Distinct Effects on Fluid-Phase and Receptor-Mediated Endocytosis, but Does Not Impair Phagocytosis in J774 Macrophages

Tyteca

Smissen²,

Mettlen

et al. 2002

Experimental Cell Research

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“…In mammalian cells but perhaps not in yeast, the endocytic pathway can be divided into two functional territories, recycling/reutilization vs. degradation, which are linked by membrane transport. The plasma membrane and early endosomal elements belong to the recycling/reutilization territory through which large amounts of fluid or membrane are trafficked, 30% of the cell volume and the surface area of the plasma membrane per hour (Steinman et al 1976;Besterman and Low 1983;Steinman et al 1983), or perhaps more (Howes et al 2010a). In early endosomes, cargo is sorted for recycling/reutilization or degradation.…”

Section: Pi(3)pmentioning

confidence: 99%

Lipid Sorting and Multivesicular Endosome Biogenesis

Bissig

Grüenberg

2013

Cold Spring Harbor Perspectives in Biology

133

107

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Intracellular organelles, including endosomes, show differences not only in protein but also in lipid composition. It is becoming clear from the work of many laboratories that the mechanisms necessary to achieve such lipid segregation can operate at very different levels, including the membrane biophysical properties, the interactions with other lipids and proteins, and the turnover rates or distribution of metabolic enzymes. In turn, lipids can directly influence the organelle membrane properties by changing biophysical parameters and by recruiting partner effector proteins involved in protein sorting and membrane dynamics. In this review, we will discuss how lipids are sorted in endosomal membranes and how they impact on endosome functions.

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“…To reduce non-specific toxicity the optimal drug delivery system requires cleavage of the drug after the conjugate has bound to the tumour associated antigen and internalised. The majority of large molecules are transported by constitutive pinocytosis (Besterman & Low, 1983). Both 791T/36 and 228 monoclonal antibodies enter tumour cells by this route (Garnett et al, 1986b;Byers et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

Enhanced recognition of human colorectal tumour cells using combinations of monoclonal antibodies

Durrant

Robins²,

Ballantyne³

et al. 1989

Br J Cancer

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A variety of monoclonal antibodies reactive with colorectal tumour associated antigens have been described (Steplewski et al., 1982;Herlyn et al., 1979;Lindholm et al., 1983;Durrant et al., 1986a). However, one problem that needs to be solved before monoclonal antibodies can be used effectively for imaging or therapy is the heterogeneity of cell surface antigen expression on tumours (Durrant et al., 1986a;Brattain et al., 1981;Dexter et al., 1981 tissues (Embleton et al., 1981; Price et al., 1983a, b). It has been used extensively for colorectal tumour imaging (Farrands et al., 1982;Armitage et al., 1983) and linked to ricin A chain has been screened in a phase 1 clinical trial (Byers et al., 1989). 228 recognises carcinoembryonic antigen and not normal cross-reacting antigen. Its main normal reactivity is with secretory components of the gastrointestinal tract. It has also been shown to localise in tumours of colorectal cancer patients (Pimm et al., 1986). 161 antibody also recognises CEA but also cross-reacts with NCA. It therefore binds to a number of normal tissues, including liver and kidney tissues and would therefore be of limited clinical value. C14 recognises the Y haptenic blood group antigen which is expressed widely on colorectal cancers and adenomas (Lloyd et al., 1983;Brown et al., 1984;Abe et al., 1986; Durrant et al., 1986a, b;Ernst et al., 1986). Its main reactivity with normal tissues is restricted to secretory epithelial tissues in individuals who secrete blood group substances (Brown et al., 1984 Our results indicate that more colorectal cancers were recognised and the intensity of staining was increased by using combinations of monoclonal antibodies when compared to a single antibody.

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Endocytosis: a review of mechanisms and plasma membrane dynamics

Cited by 188 publications

References 162 publications

Azithromycin, a Lysosomotropic Antibiotic, Has Distinct Effects on Fluid-Phase and Receptor-Mediated Endocytosis, but Does Not Impair Phagocytosis in J774 Macrophages

Azithromycin, a Lysosomotropic Antibiotic, Has Distinct Effects on Fluid-Phase and Receptor-Mediated Endocytosis, but Does Not Impair Phagocytosis in J774 Macrophages

Lipid Sorting and Multivesicular Endosome Biogenesis

Enhanced recognition of human colorectal tumour cells using combinations of monoclonal antibodies

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