Endocytosis in health and disease—a thematic issue dedicated to Renate Fuchs

Ellinger, Isabella; Pietschmann, Péter

doi:10.1007/s10354-016-0454-1

Cited by 15 publications

(13 citation statements)

References 6 publications

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“…This process has been shown to regulate multiple important cellular functions, such as nutrient uptake, plasma membrane recycling, antigen presentation, intracellular signal transduction, the removal of aged or dead cells from the body, and the defense against microbes (Doherty & McMahon, 2009;Di Fiore & von Zastrow, 2014). The impairment of the endocytic pathway has been linked to a number of human diseases, such as diabetes, neurodegenerative diseases, cardiovascular disease, and cancer (Ellinger & Pietschmann, 2016). Although the endocytic pathway has been studied in detail in many biological processes and has been demonstrated to exert multiple important cellular functions, its role in the regulation of stem cell functions still remains largely unexplored.…”

Section: Discussionmentioning

confidence: 99%

Lipoic acid rejuvenates aged intestinal stem cells by preventing age‐associated endosome reduction

Qiao

Zhuo

et al. 2020

EMBO Reports

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The age-associated decline of adult stem cell function is closely related to the decline in tissue function and age-related diseases. However, the underlying mechanisms that ultimately lead to the observed functional decline of stem cells still remain largely unexplored. This study investigated Drosophila midguts and found a continuous downregulation of lipoic acid synthase, which encodes the key enzyme for the endogenous synthesis of alpha-lipoic acid (ALA), upon aging. Importantly, orally administration of ALA significantly reversed the age-associated hyperproliferation of intestinal stem cells (ISCs) and the observed decline of intestinal function, thus extending the lifespan of Drosophila. This study reports that ALA reverses age-associated ISC dysfunction by promoting the activation of the endocytosis-autophagy network, which decreases in aged ISCs. Moreover, this study suggests that ALA may be used as a safe and effective anti-aging compound for the treatment of ISCdysfunction-related diseases and for the promotion of healthy aging in humans.

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Section: Discussionmentioning

confidence: 99%

Lipoic acid rejuvenates aged intestinal stem cells by preventing age‐associated endosome reduction

Qiao

Zhuo

et al. 2020

EMBO Reports

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“…The term "endocytosis" was coined by Christian de Duve in the 1960s to describe a cellular process in which the invagination of the limiting plasma membrane leads to the intracellular formation of vesicles encapsulating extracellular material (Fürthauer and Smythe, 2014). Various functions are now assigned to endocytosis, a key homeostatic mechanism that regulates major cellular processes such as provision of educts for biochemical synthesis of macromolecules, receptor down-regulation, intracellular signaling, antigen presentation (Miaczynska et al, 2004;Miaczynska and Stenmark, 2008;Ellinger and Pietschmann, 2016), or as the main route for EV internalization (Koumangoye et al, 2011;Nanbo et al, 2013;Mulcahy et al, 2014;Heusermann et al, 2016;Nakase et al, 2016;Durak-Kozica et al, 2018;Yao et al, 2018). Indeed, EV uptake through this route is rapid, with EVs identified inside cells within few minutes after their application to the culture medium (Feng et al, 2010).…”

Section: "Eating and Drinking" Evsmentioning

confidence: 99%

“…This close proximity with the nucleus is hijacked for the delivery of viral genomic material to "the control center of the cell" and may hint to a possible shared delivery mechanism also used by EVs (Mercer et al, 2010). Endocytosis is a broad term that includes a range of internalization pathways that include cell eating ("phagocytosis") and cell drinking ("pinocytosis") processes, both involved in EV internalization (Feng et al, 2010;Tian et al, 2014a;Ellinger and Pietschmann, 2016;Holder et al, 2016;Chiba et al, 2018;Horibe et al, 2018;Ogese et al, 2019;Verweij et al, 2019; Figure 1).…”

Section: "Eating and Drinking" Evsmentioning

confidence: 99%

Hijacking Endocytosis and Autophagy in Extracellular Vesicle Communication: Where the Inside Meets the Outside

Pedrioli

Paganetti

2021

Front. Cell Dev. Biol.

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Extracellular vesicles, phospholipid bilayer-membrane vesicles of cellular origin, are emerging as nanocarriers of biological information between cells. Extracellular vesicles transport virtually all biologically active macromolecules (e.g., nucleotides, lipids, and proteins), thus eliciting phenotypic changes in recipient cells. However, we only partially understand the cellular mechanisms driving the encounter of a soluble ligand transported in the lumen of extracellular vesicles with its cytosolic receptor: a step required to evoke a biologically relevant response. In this context, we review herein current evidence supporting the role of two well-described cellular transport pathways: the endocytic pathway as the main entry route for extracellular vesicles and the autophagic pathway driving lysosomal degradation of cytosolic proteins. The interplay between these pathways may result in the target engagement between an extracellular vesicle cargo protein and its cytosolic target within the acidic compartments of the cell. This mechanism of cell-to-cell communication may well own possible implications in the pathogenesis of neurodegenerative disorders.

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“…Internalized molecules from the plasma membrane can be recycled back to the cell surface or be degraded in the cell. Endocytosis orchestrates numerous cellular processes, which include membrane formation, cell signal transduction, adhesion, motility, immune response, membrane turnover, lipid homeostasis, uptake of nutrients, and development in response to the ambient environmental changes ( 1 – 3 ). Based on vesicular membrane components and cargoes ( 4 ) identified by electron microscopy, endocytic pathways can be broadly divided into clathrin-mediated endocytosis ( 5 ), and clathrin-independent endocytosis, which is further subdivided into caveolae-dependent endocytosis ( 6 ), phagocytosis (“cell eating”) ( 7 , 8 ), macropinocytosis (“cell drinking”) ( 9 ), cholesterol-sensitive pathway ( 10 , 11 ), and clathrin-independent carrier/GPI-AP-enriched early endosomal compartment (CLIC/GEEC) pathway endocytosis ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Podocyte Endocytosis in Regulating the Glomerular Filtration Barrier

2022

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Endocytosis is a mechanism that internalizes and recycles plasma membrane components and transmembrane receptors via vesicle formation, which is mediated by clathrin-dependent and clathrin-independent signaling pathways. Podocytes are specialized, terminally differentiated epithelial cells in the kidney, located on the outermost layer of the glomerulus. These cells play an important role in maintaining the integrity of the glomerular filtration barrier in conjunction with the adjacent basement membrane and endothelial cell layers within the glomerulus. An intact podocyte endocytic machinery appears to be necessary for maintaining podocyte function. De novo pathologic human genetic mutations and loss-of-function studies of critical podocyte endocytosis genes in genetically engineered mouse models suggest that this pathway contributes to the pathophysiology of development and progression of proteinuria in chronic kidney disease. Here, we review the mechanism of cellular endocytosis and its regulation in podocyte injury in the context of glomerular diseases. A thorough understanding of podocyte endocytosis may shed novel insights into its biological function in maintaining a functioning filter and offer potential targeted therapeutic strategies for proteinuric glomerular diseases.

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Endocytosis in health and disease—a thematic issue dedicated to Renate Fuchs

Cited by 15 publications

References 6 publications

Lipoic acid rejuvenates aged intestinal stem cells by preventing age‐associated endosome reduction

Lipoic acid rejuvenates aged intestinal stem cells by preventing age‐associated endosome reduction

Hijacking Endocytosis and Autophagy in Extracellular Vesicle Communication: Where the Inside Meets the Outside

Podocyte Endocytosis in Regulating the Glomerular Filtration Barrier

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