Endoderm and heart development

Lough, John; Sugi, Yukiko

doi:10.1002/(sici)1097-0177(200004)217:4<327::aid-dvdy1>3.0.co;2-k

Cited by 200 publications

(94 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vertebrate embryos, the precardiac mesoderm cells become committed to their cardiac fate in bilateral regions at the level of Hensen's node by inductive signals emanating from the anterior definitive endoderm (Sugi and Lough, 1994;Schultheiss et al, 1995;Lough and Sugi, 2000). At the same time, repressive signals from the developing neural tissue and Node regions have been shown to inhibit cardiogenesis (Jacobson and Sater, 1988;Climent et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Early temporal‐specific responses and differential sensitivity to lithium and Wnt‐3A exposure during heart development

Manisastry

Han

Linask

2006

Developmental Dynamics

View full text Add to dashboard Cite

Members of both Wnt and bone morphogenetic protein (BMP) families of signaling molecules are important in heart development. We previously demonstrated that ␤-catenin, a key downstream intermediary of the canonical Wnt signaling pathway, delineates the dorsal boundary of the cardiac compartments in an anteroposterior progression. We hypothesized the progression involves canonical Wnt signaling and reflects development of the primary body axis of the embryo. A similar anteroposterior signaling wave leading to cardiac cell specification involves inductive signaling by BMP-2 synthesized by the underlying endoderm in anterior bilateral regions. Any molecule that disrupts the normal balance of Wnt and BMP concentrations within the heart field may be expected to affect early heart development. The canonical Wnt signaling step mimicked by lithium involves inactivation of glycogen synthase kinase-3␤ (GSK-3␤; Klein and Melton [1996] Proc. Natl. Acad. Sci. U. S. A. 93:8455-8459). We show that lithium, Wnt-3A, and an inhibitor of GSK-3␤, SB415286, affect early heart development at the cardiac specification stages. We demonstrate that normal expression patterns of key signaling molecules as Notch-1 and Dkk-1 are altered in the anterior mesoderm within the heart fields by a one-time exposure to lithium, or by noggin inhibition of BMP, at Hamburger and Hamilton (HH) stage 3 during chick embryonic development. The severity of developmental defects is greatest with exposure to lithium or Wnt-3A at HH stage 3 and decreases at HH stage 4. Taken together, our results demonstrate that there are temporal-specific responses and differential sensitivities to lithium/Wnt-3A exposure during early heart development.

show abstract

Section: Discussionmentioning

confidence: 99%

Early temporal‐specific responses and differential sensitivity to lithium and Wnt‐3A exposure during heart development

Manisastry

Han

Linask

2006

Developmental Dynamics

View full text Add to dashboard Cite

show abstract

“…Moreover, as the ectopically transplanted cardiac primordium undergoes morphogenetic processes (e.g., looping at the transplantation site) that ultimately determine the atria and ventricles, this system allows the elucidation of inductive interactions with proximal tissues (Nascone and Mercola, 1995;Branford et al, 2000;Lough and Sugi, 2000). In the transplantation experiment, the transplanted cardiac primordium not only differentiated into a beating heart, but this heart communicated with the vascular system of the host and was incorporated into the systemic circulation.…”

Section: Cardiac Organ Engineering: An In Vitro-generated Frog Heart mentioning

confidence: 99%

In vitro organogenesis from undifferentiated cells in Xenopus

Asashima

Ito

Chan

et al. 2009

Developmental Dynamics

View full text Add to dashboard Cite

Amphibians have been used for over a century as experimental animals. In the field of developmental biology in particular, much knowledge has been accumulated from studies on amphibians, mainly because they are easy to observe and handle. Xenopus laevis is one of the most intensely investigated amphibians in developmental biology at the molecular level. Thus, Xenopus is highly suitable for studies on the mechanisms of organ differentiation from not only a single fertilized egg, as in normal development, but also from undifferentiated cells, as in the case of in vitro organogenesis. Based on the established in vitro organogenesis methods, we have identified many genes that are indispensable for normal development in various organs. These experimental systems are useful for investigations of embryonic development and for advancing regenerative medicine. Developmental Dynamics 238:1309 -1320, 2009.

show abstract

“…Alternatively, one structure could depend on correct signaling from the other for its early morphogenesis to proceed normally. Of particular interest, avian cardiogenesis is induced by anterior endoderm-derived signals (Schultheiss et al, 1995;Lough and Sugi, 2000), suggesting that reciprocal interactions between adjacent germ layers are important in the foregut region. Whether this involves the thyroid progenitor zone, which constitutes a relatively large portion of the endoderm facing the secondary heart field and the presumptive cardiac outflow tract, is an open intriguing question.…”

Section: Is Thyroid Morphogenesis Coordinated With Heart Development?mentioning

confidence: 99%

Morphogenesis of the thyroid gland

Fagman

Nilsson

2010

Molecular and Cellular Endocrinology

130

View full text Add to dashboard Cite

Congenital hypothyroidism is mainly due to structural defects of the thyroid gland, collectively known as thyroid dysgenesis. The two most prevalent forms of this condition are abnormal localization of differentiated thyroid tissue (thyroid ectopia) and total absence of the gland (athyreosis). The clinical picture of thyroid dysgenesis suggests that impaired specification, proliferation and survival of thyroid precursor cells and loss of concerted movement of these cells in a distinct spatiotemporal pattern are major causes of malformation. In normal development the thyroid primordium is first distinguished as a thickening of the anterior foregut endoderm at the base of the prospective tongue. Subsequently, this group of progenitors detaches from the endoderm, moves caudally and ultimately differentiates into hormone-producing units, the thyroid follicles, at a distant location from the site of specification. In higher vertebrates later stages of thyroid morphogenesis are characterized by shape remodelling into a bilobed organ and the integration of a second type of progenitors derived from the caudal-most pharyngeal pouches that will differentiate into C-cells. The present knowledge of thyroid developmental dynamics has emerged from embryonic studies mainly in chicken, mouse and more recently also in zebrafish. This review will highlight the key morphogenetic steps of thyroid organogenesis and pinpoint which crucial regulatory mechanisms are yet to be uncovered. Considering the coincidence of thyroid dysgenesis and congenital heart malformations the possible interactions between thyroid and cardiovascular development will also be discussed.

show abstract

Endoderm and heart development

Cited by 200 publications

References 119 publications

Early temporal‐specific responses and differential sensitivity to lithium and Wnt‐3A exposure during heart development

Early temporal‐specific responses and differential sensitivity to lithium and Wnt‐3A exposure during heart development

In vitro organogenesis from undifferentiated cells in Xenopus

Morphogenesis of the thyroid gland

Contact Info

Product

Resources

About