Endodermal sinus tumor of the paranasal sinuses

Mishra, Anupam; El‐Naggar, Adel K.; DeMonte, Franco; Hanna, Ehab Y.

doi:10.1002/hed.20711

Cited by 22 publications

(12 citation statements)

References 19 publications

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“…In the sinonasal tract, nasopharynx, and oral cavity, some 30 cases of teratocarcinosarcoma with unusual neuroectodermal elements have been reported (6,7,19,20). Their similarities with the present case reside in their presentation in a similar advanced age group, malignant behavior, and histology containing areas of unusual elements such as squamous carcinoma, rhabdomyosarcoma, and malignant neurologic components.…”

supporting

confidence: 49%

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Malignant Müllerian Mixed Tumor of the Ovary Associated With Yolk Sac Tumor, Neuroepithelial and Trophoblastic Differentiation (Teratoid Carcinosarcoma)

García-Galvis

Cabrera-Ozoria

Fernández

et al. 2008

International Journal of Gynecological Pathology

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This paper reports a unique stage IV complex ovarian carcinosarcoma in a 69-year patient that had malignant mixed müllerian epithelial and mesenchymal components and also other malignant differentiation such as neuroectodermal (small cell, neuroendocrine, neuroglial, neuronal, and melanocytic) and endodermal (yolk sac tumor) tissues and trophoblastic cells. As its phenotype comprised elements derived embryologically from the 3 germ layers, it posed the problem of differentiating it from a teratoma originated from germ cells, with which it shared a trilaminar type differentiation. It was different from a teratoma as it coexisted with, and possibly originated from, a somatic tumor, namely a characteristic endometrioid adenocarcinoma. All neoplastic tissue patterns present in the neoplasm were malignant per se without an apparent gradient of maturation or presence of organoid structures.

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supporting

confidence: 49%

“…It would seem that perhaps some of the reported sinonasal teratocarcinosarcoma cases could have a germ cell origin, a hypothesis supported by their age of presentation and midline situation, which is a characteristic location for germ cell tumors. Indeed, some of the YSTs reported in children are likely to be of germ cell origin (20).…”

mentioning

confidence: 99%

Malignant Müllerian Mixed Tumor of the Ovary Associated With Yolk Sac Tumor, Neuroepithelial and Trophoblastic Differentiation (Teratoid Carcinosarcoma)

García-Galvis

Cabrera-Ozoria

Fernández

et al. 2008

International Journal of Gynecological Pathology

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“…1 The prognosis of patients, especially children with ESTs, is unknown, although there have been reports of successful management by surgery, radiotherapy, and adjuvant chemotherapy (cisplatin, bleomycin, and vinblastine). 10,[16][17][18] Weedon and Musgrave 19 described a female infant who had an YST in the maxillofacial area that was diagnosed at the age of 10 months, and she died 1 month later. Margo et al 14 reported 5 cases of YSTs of the orbit occurring in children 3 months to 4 years old.…”

Section: Discussionmentioning

confidence: 98%

Yolk-Sac Tumor of the Postauricular Region: Case Report and Review of the Literature

Rozbahany

Hasanzadazar

Latifi

et al. 2012

Journal of Oral and Maxillofacial Surgery

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“…To our knowledge, adult YST in the nasal area is very rare, and only six cases have been reported in the English literature. YSTs of the nasal cavity and paranasal sinuses in children are mostly pure YSTs, while those in adults are mostly accompanied by cancer, such as teratocarcinosarcoma or choriocarcinoma, [4][5][6][7]12,13 suggesting that YSTs of the nasal cavity and paranasal sinuses in adults may originate from somatic cells.…”

Section: Discussionmentioning

confidence: 99%

“…4 Unlike YSTs in children with pure YST morphology, YSTs in adults are frequently accompanied by cancer, teratocarcinosarcoma, and other components. [4][5][6][7] Here, we have reported a case of a neoplasm with a morphology and immunophenotype of pure YST. However, SMARCB1 (INI-1) immunohistochemical staining and fluorescence in situ hybridization (FISH) revealed SMARCB1 (INI-1)-deficient carcinoma.…”

Section: Introductionmentioning

confidence: 98%

Case Report: SMARCB1 (INI-1)-Deficient Carcinoma of the Nasal Cavity with Pure Yolk Sac Tumor Differentiation and Elevated Serum AFP Levels

Li¹,

Han²,

Xu³

et al. 2021

OTT

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In adults, yolk sac tumors (YSTs) in the nasal cavity and paranasal sinuses are very rare. To date, only six cases have been reported in the English literature. YSTs in adults are often accompanied by cancer, teratocarcinosarcoma, and other malignant components. Here, we have reported a case of nasal tumor in a 55-year-old man with nasal obstruction and epistaxis. Morphologically, the tumor showed histological characteristics of pure YST. Immunohistochemical staining showed diffuse expression of SALL4, CDX2, and GPC-3 accompanied by sporadic expression of alpha-fetoprotein (AFP) and CD117. After 20 and 40 days of operation, the serum AFP level was 220.30 and 43.60 ng/mL (normal, <7 ng/mL), respectively, which supported the pathological diagnosis of YST. However, we further performed immunohistochemical staining and fluorescence in situ hybridization using an INI-1 probe to detect the status of INI-1 in tumor cells. The results revealed that INI-1 was absent in tumor cells. Hence, we corrected the diagnosis to SMARCB1 (INI-1)-deficient carcinoma of the nasal cavity with YST differentiation. The patient underwent surgery and adjuvant radiotherapy in our hospital without evidence of recurrence or metastasis at the 6-month follow-up. The serum AFP level had also normalized. In conclusion, our case demonstrates that INI-1-deficient carcinoma may exhibit, a pure YST differentiation and immunophenotype, and elevated serum AFP levels. In adults, YST in the nasal cavity may represent INI-1-deficient carcinoma, which may be a potential diagnostic pitfall.

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Endodermal sinus tumor of the paranasal sinuses

Abstract: Because of the rarity of this entity, no standardized treatment protocol has been defined. The involvement of the anterior skull base in our case necessitated a radical craniofacial resection, despite a partial response to chemotherapy.

Cited by 22 publications

References 19 publications

Malignant Müllerian Mixed Tumor of the Ovary Associated With Yolk Sac Tumor, Neuroepithelial and Trophoblastic Differentiation (Teratoid Carcinosarcoma)

Malignant Müllerian Mixed Tumor of the Ovary Associated With Yolk Sac Tumor, Neuroepithelial and Trophoblastic Differentiation (Teratoid Carcinosarcoma)

Yolk-Sac Tumor of the Postauricular Region: Case Report and Review of the Literature

Case Report: SMARCB1 (INI-1)-Deficient Carcinoma of the Nasal Cavity with Pure Yolk Sac Tumor Differentiation and Elevated Serum AFP Levels

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