Endodermal sinus (yolk sac) tumors in infants and children

Yolk sac tumor of upper lip: A case report

“…The major pathologic characteristics of YSTs include a reticular pattern, a solid pattern, a hepatoid pattern with hyaline globules, a festoon pattern, enteric differentiation, Schiller-Duval bodies, the presence of a granulomatous tissue reaction and a polyvesicular vitelline pattern (10,11). Schiller-Duval bodies have been reported as a common feature to extragonadal YSTs, as observed in large quantities in a previous study (12). Typical Schiller-Duval bodies comprise cuboidal or low columnar-shaped tumor cells surrounding the capillaries of a thin-walled sinus (13,14).…”

Malignant head and neck germ cell tumours

“…When these cells remain viable, they may give rise to tumours in the retroperitoneum, sacral region, mediastinum or pineal region. (Brown, 1976;Juckes et al, 1979;Sullivan etal, 1983;Sue et al, 1990).…”

“…Malignant germ cell tumours are more frequent in females and usually appear during the first three years of life (Sullivan et al, 1983;Harms and Janig, 1986). The region of the neck and anterior mediastinum is the fourth most frequently affected anatomical site, after the gonads, sacrococcygeal region, and the retroperitoneum (Juckes et al, 1979). The extracranial head and neck locations predominantly affected are the soft tissues of the mid-line or lateral neck, orbit, nasopharynx, mandible, maxilla, and cheek (Sullivan et al, 1983;Shebib et al, 1989;Sue et al, 1990;Dehner et al, 1990).…”