Endodontic Infection–induced Inflammation Resembling Osteomyelitis of the Jaws in Toll-like Receptor 2/Interleukin 10 Double-knockout Mice

Sasaki, Hajime; Furusho, Hisako; Rider, Daniel; Dobeck, Justine M.; Kuo, Winston Patrick; Fujimura, Akiko; Yoganathan, Subbiah; Hirai, Kazumasa; Xu, Shuang; Sasaki, Kohsuke; Stashenko, Philip

doi:10.1016/j.joen.2018.10.007

Cited by 16 publications

(13 citation statements)

References 24 publications

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“…IL‐10 is known to prevent excessive inflammation during the course of infection (36). More recently, it was demonstrated that mice lacking Toll‐like receptor 2 and IL‐10 develop osteomyelitis‐like lesions after endodontic infection induction, further confirming a relevant role for IL‐10 to control AP progression (37). Nonetheless, we had only three patients with detectable levels of IL‐10, irrespective of T2DM or AP diagnosis.…”

Section: Discussionmentioning

confidence: 83%

Serum levels of inflammatory markers and HbA1c in patients with type 2 diabetes and apical periodontitis: Preliminary findings

et al. 2021

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This pilot study assessed the glycaemic control and the serum levels of inflammatory mediators in type 2 diabetes (T2DM) patients with apical periodontitis (AP). Thirty individuals were divided into four groups: Healthy (H); with AP (AP); with T2DM (T2DM); and with T2DM and AP (T2DM-AP). Demographic and pharmacological data were registered. The body mass index (BMI) and the levels of glycated haemoglobin (HbA1c) and IL-1b, IL-6, IL-10, CCL3 and CCL4 were evaluated. AP areas were determined radiographically. Mean age was 64 AE 12 years, with 63% females. Most T2DM patients were under treatment with metformin and antihypertensives. BMI and H1bAc were significantly higher in T2DM patients in relation to H and AP groups. The AP areas were larger in the T2DM-AP group, compared with the AP group. These preliminary findings suggest no influence of AP on glycaemic control or inflammatory levels amongst T2DM patients, although T2DM increased the AP severity.

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Section: Discussionmentioning

confidence: 83%

Serum levels of inflammatory markers and HbA1c in patients with type 2 diabetes and apical periodontitis: Preliminary findings

et al. 2021

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“…(16) Though orientation is often not described in detail, many papers reporting dentoalveolar analyses use one or more of the molars as the most consistent anatomical landmarks to orient mandibles/maxillae, as can be deduced from their figures. (11,13,23,44,45,48,(68)(69)(70)(71)(72)(73)(74)(75) Incisors or whole mandible/maxilla approaches are also sometimes used for orientation. (9,72,76,77) Here, we describe the use of the mandibular first molar (M1) as a guide for orientation.…”

Section: Orientationmentioning

confidence: 99%

Guidelines for Micro–Computed Tomography Analysis of Rodent Dentoalveolar Tissues

et al. 2021

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“…From Sasaki et al . (2019) – ‘This model will be a valuable tool not only for the further elucidation of the pathobiology of osteomyelitis but also for the development of new therapies to accelerate bone and wound healing’.…”

Section: Introductionmentioning

confidence: 99%

“…From Sasaki et al . (2019) – ‘The authors thank Drs YoshimitsuAbiko (Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan), KiichiHirota (Kansai Medical University, Hirakata City, Osaka, Japan), and Akio Ohta (The Institute of Biomedical Research and Innovation, Kobe City, Hyogo, Japan) for their advice on the experimental design and for helpful discussions’.…”

Section: Introductionmentioning

confidence: 99%

PRIASE 2021 guidelines for reporting animal studies in Endodontology: explanation and elaboration

et al. 2021

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Laws and ethics require that before conducting human clinical trials, a new material, device or drug may have to undergo testing in animals in order to minimize health risks to humans, unless suitable supporting grandfather data already exist. The Preferred Reporting Items for Animal Studies in Endodontology (PRIASE) 2021 guidelines were developed exclusively for the specialty of Endodontology by integrating and adapting the ARRIVE (Animals in Research: Reporting In Vivo Experiments) guidelines and the Clinical and Laboratory Images in Publications (CLIP) principles using a validated consensus‐based methodology. Implementation of the PRIASE 2021 guidelines will reduce potential sources of bias and thus improve the quality, accuracy, reproducibility, completeness and transparency of reports describing animal studies in Endodontology. The PRIASE 2021 guidelines consist of a checklist with 11 domains and 43 individual items and a flowchart. The aim of the current document is to provide an explanation for each item in the PRIASE 2021 checklist and flowchart and is supplemented with examples from the literature in order for readers to understand their significance and to provide usage guidance. A link to the PRIASE 2021 explanation and elaboration document and PRIASE 2021 checklist and flowchart is available on the Preferred Reporting Items for study Designs in Endodontology (PRIDE) website (http://pride-endodonticguidelines.org/priase/).

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Endodontic Infection–induced Inflammation Resembling Osteomyelitis of the Jaws in Toll-like Receptor 2/Interleukin 10 Double-knockout Mice

Cited by 16 publications

References 24 publications

Serum levels of inflammatory markers and HbA1c in patients with type 2 diabetes and apical periodontitis: Preliminary findings

Serum levels of inflammatory markers and HbA1c in patients with type 2 diabetes and apical periodontitis: Preliminary findings

Guidelines for Micro–Computed Tomography Analysis of Rodent Dentoalveolar Tissues

PRIASE 2021 guidelines for reporting animal studies in Endodontology: explanation and elaboration

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