Successful root canal treatment relies primarily on thorough shaping, cleaning, and filling of the entire root canal system. Neglecting even a single canal can significantly raise the risk of post-treatment apical periodontitis. While the distal root of mandibular second molars typically has one canal, they can also present with anatomical variations, including the presence of a Vertucci Type V configuration. This article discusses a case in which a Vertucci Type V configuration in a mandibular second molar was effectively identified and treated.