“…Among several intracanal dressings used for teeth with no pulp vitality and with chronic periapical lesions, calcium hydroxide (Ca(OH) 2 ) has been regarded as the best option, and it has been widely recommended and used because of its proven antibacterial properties (1), periapical tissue healing stimulation (2), biocompatibility (3), antiexudate activity (4), and necrotic tissues dissolution propriety (5). The dissociation of Ca(OH) 2 into calcium and hydroxyl ions is responsible for the alkalinization of the cavity, which is not conducive to bacterial development and proliferation.…”