Endogene Endophthalmitis: Ursachen, Keimspektrum, Therapie und Visusverlauf

Mayer, Christian; Loos, D; Feucht, Nikolaus; Zapp, Daniel; Prahs, Philipp; Tandogan, Tamer; Khoramnia, Ramin

doi:10.1055/s-0044-101152

Cited by 7 publications

(1 citation statement)

References 28 publications

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“…Endogenous endophthalmitis (EE) is a less common but serious intraocular infection caused by the spread of infectious agents from distant foci of infection to the eye through the bloodstream [1]. The condition has a very poor visual prognosis, and many patients have underlying or related immunosuppression [2]. Endophthalmitis has a short clinical course, hence early diagnosis and treatment are critical for visual recovery.…”

Section: Introductionmentioning

confidence: 99%

Study of clinical traits and systemic immune inflammation index assessments in patients with endogenous endophthalmitis over the last ten years

Niu,

Yan,

Wang

et al. 2024

BMC Ophthalmol

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Purpose The clinical aspects and prognosis of eyes with endogenous endophthalmitis were compared over the last ten years. The occurrence and progression of endophthalmitis are linked to the systemic immune inflammation index (SII) and clinical features. Methods The study comprised patients with endogenous endophthalmitis and 64 patients without endophthalmitis who were treated at Hebei Province Eye Hospital in the last ten years. According to the prognostic visual acuity, patients with endophthalmitis were split into two groups: Group A and Group B. Underlying disease (hypertension, diabetes, tuberculosis), infection risk (liver abscess, urinary tract infection, and recent abdominal surgery), signs and symptoms, and complete blood count were among the evaluation parameters (neutrophil count, lymphocyte count, monocyte count, platelet count, red blood cell distribution width). The NLR, PLR, MLR, and SII values were calculated. A nonparametric test was used to examine the clinical features and complete blood count results of patients in each group. To determine the parameters linked to endophthalmitis progression, researchers used principal component and ordinal logistic regression analyses. Results The study comprised a total of 25 eyes and 22 individuals with endogenous endophthalmitis. Infectious bacteria included Staphylococcus aureus, Micrococcus luteus, Staphylococcus hemolyticus, and so on. The visual acuity of the affected eye ranged from 2.7 (1.55, 2.7) LogMAR to 1.22 (0.6, 2.7) LogMAR during the 6-month to 8-year follow-up period. The neutrophil, monocyte, and PLT counts, NLR, PLR, and SII values and other markers were considerably higher in Groups A and B than in the control group. The likelihood model of the SII and sex, age, onset time, diabetes, hypertension, monocyte count, and red blood cell distribution was the best, and its increase was strongly connected with the occurrence and progression of endophthalmitis, according to ordinal regression analysis. Conclusion Patients with endophthalmitis had significantly higher blood neutrophil, monocyte, and PLT counts and SII, NLR, PLR, and MLR values. The SII can be employed as a biomarker for predicting endophthalmitis severity and prognosis.

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Section: Introductionmentioning

confidence: 99%