Endogenous antibody response to SARS-CoV-2 in patients who received monoclonal antibodies against COVID-19: A systematic review

Considerations on COVID-19 vaccination

“…Another form of passive immunization employs the use of monoclonal antibodies (mAbs) against SARS-CoV-2. This approach was covered by a systematic review of the literature by Lombardi and coworkers, that reported that the administration of mAbs to COVID-19 patients seronegative at time of administration resulted in a reduction in both antibody titers and neutralizing activity against the virus [14] . The clinical significance of those findings and underlying mechanisms remained to be understood, and might have involved the existence of pre-existing responses to SARS-CoV-2 [15] .…”