Endogenous antioxidant defences in plasma and erythrocytes of pregnant women during different trimesters of pregnancy

Ademuyiwa, Oladipo; Odusoga, OL; Adebawo, Olugbenga O.; Ugbaja, Regina Ngozi

doi:10.1080/00016340701515357

Cited by 37 publications

(28 citation statements)

References 32 publications

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“…They control the level of free radicals in cells. Although Ademuyiwa et al (37) reported that CAT activity did not change, Djordjevic et al (38) showed increased CAT activity during the course of pregnancy. Our finding that CAT activity in maternal blood decreases during pregnancy is consistent with studies carried out in pregnant ewes (39,40).…”

Section: Discussionmentioning

confidence: 97%

Malondialdehyde and nitric oxide levels and catalase, superoxide dismutase, and glutathione peroxidase levels in maternal blood during different trimesters ofpregnancy and in the cord blood of newborns

Yüksel¹,

Yiğit²

2015

Turk J Med Sci

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Background/aim: To determine whether levels of malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) change during the 3 trimesters of pregnancy, and to compare the third trimester of pregnancy with newborn cord blood in respect to the levels of MDA, NO, and antioxidant enzymes. Materials and methods:Maternal blood samples were collected at 9-13, 22-26, and 36-40 weeks of gestation. Cord blood was collected at the time of delivery.Results: NO levels and GPx activity were higher in the second and third trimesters than in the first trimester. MDA level was lower in the third trimester and SOD and CAT activities were lower in the second and third trimesters than the first trimester. In cord blood, MDA and NO levels were lower while CAT and GPx activities were higher than in the third trimester of pregnancy. Conclusion:These results suggest that the balance of free radical and antioxidant production during pregnancy ensures healthy fetus growth and development.

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Section: Discussionmentioning

confidence: 97%

Malondialdehyde and nitric oxide levels and catalase, superoxide dismutase, and glutathione peroxidase levels in maternal blood during different trimesters ofpregnancy and in the cord blood of newborns

Yüksel¹,

Yiğit²

2015

Turk J Med Sci

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“…[33] showed that obesity increases oxidative stress by raising lipid peroxidation proportionally to the degree of adiposity and low antioxidant defense. Significant changes of the oxidant/antioxidant balance still exist during normal pregnancy, due to increased basal oxygen and energy consumption in different organs including the fetoplacental unit [16]. Antioxidants are extremely important in maintaining cell function during normal pregnancy [34].…”

Section: Discussionmentioning

confidence: 99%

“…The impact of oxidative stress on the fetus and the newborn is well known [15]. Pregnancy is a state of oxidative stress [16]. Placenta tissue is rich in hormones and is an important source of pro-oxidant agents as well as antioxidant enzymes [17].…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and maternal obesity: Feto-placental unit interaction

et al. 2014

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“…Manganese is also an important cofactor for a number of enzymes, including the antioxidant manganese superoxide dismutase (Mn-SOD; Figure 2) which may protect the placenta from oxidative stress by detoxifying superoxide anions [120]. Dietary manganese is the main source of exposure under normal circumstances; current requirements for manganese, although less studied compared to other micronutrients, are shown in Table 1 and little is known about the effects of deficiency or excess of manganese on the developing human fetus or pregnancy outcome [121].…”

Section: Methodsmentioning

confidence: 99%

The Importance of Antioxidant Micronutrients in Pregnancy

Mistry

Williams

2011

Oxidative Medicine and Cellular Longevity

187

188

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Pregnancy places increased demands on the mother to provide adequate nutrition to the growing conceptus. A number of micronutrients function as essential cofactors for or themselves acting as antioxidants. Oxidative stress is generated during normal placental development; however, when supply of antioxidant micronutrients is limited, exaggerated oxidative stress within both the placenta and maternal circulation occurs, resulting in adverse pregnancy outcomes. The present paper summarises the current understanding of selected micronutrient antioxidants selenium, copper, zinc, manganese, and vitamins C and E in pregnancy. To summarise antioxidant activity of selenium is via its incorporation into the glutathione peroxidase enzymes, levels of which have been shown to be reduced in miscarriage and preeclampsia. Copper, zinc, and manganese are all essential cofactors for superoxide dismutases, which has reduced activity in pathological pregnancy. Larger intervention trials are required to reinforce or refute a beneficial role of micronutrient supplementation in disorders of pregnancies.

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Endogenous antioxidant defences in plasma and erythrocytes of pregnant women during different trimesters of pregnancy

Cited by 37 publications

References 32 publications

Malondialdehyde and nitric oxide levels and catalase, superoxide dismutase, and glutathione peroxidase levels in maternal blood during different trimesters ofpregnancy and in the cord blood of newborns

Malondialdehyde and nitric oxide levels and catalase, superoxide dismutase, and glutathione peroxidase levels in maternal blood during different trimesters ofpregnancy and in the cord blood of newborns

Oxidative stress and maternal obesity: Feto-placental unit interaction

The Importance of Antioxidant Micronutrients in Pregnancy

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