Endogenous C1-inhibitor production and expression in the heart after acute myocardial infarction

Emmens, Reindert W.; Baylan, Umit; Juffermans, Lynda J.M.; Karia, Rashmi V.; Ylstra, Bauke; Wouters, Diana; Şimşek, Suat; Ham, Marieke van; Niessen, Hans W.M.; Krijnen, Paul A.J.

doi:10.1016/j.carpath.2015.09.006

Cited by 12 publications

(9 citation statements)

References 33 publications

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“…We found that EV-SerpinG1 in the TEX fraction was associated with higher odds of HF, which points to an increased inflammatory state in these patients. Serpin G1 TEX levels in the HF patient group differ between HF patients with and without MI which is in accordance with the association of SerpinG1 with ischemia [ 49 , 50 ].…”

Section: Discussionsupporting

confidence: 76%

Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure: An Observational Study in a Dyspnoea Cohort

et al. 2016

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BackgroundSerpinF2, SerpinG1, CystatinC and CD14 are involved in inflammatory processes and plasma extracellular vesicle (EV) -levels of these proteins have been reported to be associated with systemic vascular events. Evidence is accumulating that inflammatory processes may play a pivotal role both in systemic vascular events and in heart failure. Therefore, we studied the association between plasma extracellular vesicle SerpinF2-, SerpinG1-, CystatinC and CD14-levels and the occurrence of acute heart failure in patients.Methods and ResultExtracellular vesicle protein levels of SerpinG1, SerpinF2, CystatinC and CD14 were measured in an observational study of 404 subjects presenting with dysponea at the emergency department (4B-cohort). Plasma extracellular vesicles were precipitated in a total extracellular vesicles (TEX)-fraction and in separate LDL- and HDL-subfractions. Extracellular vesicle protein levels were measured with a quantitative immune assay in all 3 precipitates. Out of 404 subjects, 141 (35%) were diagnosed with acutely decompensated heart failure. After correction for confounders (including comorbidities and medications), levels of CD14 in the HDL-fraction (OR 1.53, p = 0.01), SerpinF2 in the TEX-and LDL-fraction (ORs respectively 0.71 and 0.65, p<0.05) and SerpinG1 in the TEX-fraction (OR 1.55, p = 0.004) were statistically significantly related to heart failure. Furthermore, extracellular vesicle CD14- and SerpinF2-levels were significantly higher in heart failure patients with preserved ejection fraction than in those with reduced ejection fraction.ConclusionExtracellular vesicle levels of CD14, SerpinG1 and SerpinF2 are associated with the occurrence of heart failure in subjects suspected for acute heart failure, suggesting common underlying pathophysiological mechanisms for heart failure and vascular events.

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Section: Discussionsupporting

confidence: 76%

Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure: An Observational Study in a Dyspnoea Cohort

et al. 2016

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“…30 Among the altered complement -related factors in the present study, SERPING1, a member of a serine proteinase inhibitor (SERPIN) family, is a C1 inhibitor that regulates both complement activation and blood coagulation. 31,32 Consistent with our findings, Emmens et al 33 found that endogenous SERPING1 likely plays an important role in the regulation of complement activity following acute myocardial infarction, indicating that SERPING1 might be a novel biomarker and therapeutic target in ischemic heart disease. In summary, quantitative proteomic analysis identified differential protein expression in the left ventricle that can distinguish between patients with ICM and healthy individuals.…”

Section: Bioinformatics Analysis Of the Identified Pro-supporting

confidence: 90%

An altered left ventricle protein profile in human ischemic cardiomyopathy revealed in comparative quantitative proteomics

Yi¹,

Jiang²,

Gao³

et al. 2019

Kardiol Pol

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“…Interestingly the complement regulator C1 inhibitor was found to colocalize intracellularly in cardiomyoblasts and endothelial cells with the activation fragments C4d and C3d in a rat model of myocardial infarction (Emmens et al, 2016). Furthermore, the complement regulators FH and FI are also present in the cytoplasm of endothelial cells and the authors observed that these proteins are not secreted upon treatment with histamine, which usually induces the 'spillage' of innate effector molecules (Turner et al, 2015).…”

Section: The Complosome In Non-immune Cellsmentioning

confidence: 97%

Intracellular complement − the complosome − in immune cell regulation

Arbore

Kemper

Kolev

2017

Molecular Immunology

175

158

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The complement system was defined over a century ago based on its ability to "complement" the antibody-mediated and cell-mediated immune responses against pathogens. Today our understanding of this ancient part of innate immunity has changed substantially and we know now that complement plays an undisputed pivotal role in the regulation of both innate and adaptive immunity. The complement system consists of over 50 blood-circulating, cell-surface expressed and intracellular proteins. It is key in the recognition and elimination of invading pathogens, also in the removal of self-derived danger such as apoptotic cells, and it supports innate immune responses and the initiation of the general inflammatory reactions. The long prevailing classic view of complement was that of a serum-operative danger sensor and first line of defence system, however, recent experimental and clinical evidences have demonstrated that "local" tissue and surprisingly intracellular complement (the complosome) activation impacts on normal cell physiology. This review will focus on novel aspects of intracellular complement activation and its unexpected roles in basic cell processes such as metabolism. We also discuss what the existence of the complosome potentially means for how the host handles intracellular pathogens such as viruses.

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Endogenous C1-inhibitor production and expression in the heart after acute myocardial infarction

Cited by 12 publications

References 33 publications

Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure: An Observational Study in a Dyspnoea Cohort

Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure: An Observational Study in a Dyspnoea Cohort

An altered left ventricle protein profile in human ischemic cardiomyopathy revealed in comparative quantitative proteomics

Intracellular complement − the complosome − in immune cell regulation

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