Endogenous Cerberus activity is required for anterior head specification in<i>Xenopus</i>

Silva, Cristina; Filipe, Mario; Kuerner, Klaus-Michael; Steinbeißer, Herbert; Belo, José António

doi:10.1242/dev.00705

Cited by 45 publications

(44 citation statements)

References 53 publications

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“…Xenopus Cerberus binds to Nodal, BMP, and Wnt proteins via independent sites and inhibits all three signaling pathways, which leads to simultaneous head formation and trunk inhibition (Piccolo et al 1999). Conversely, Morpholino-mediated knockdown of Cerberus in Xenopus embryos impairs head induction (Silva et al 2003;Kuroda et al 2004).…”

Section: Cerberusmentioning

confidence: 99%

Secreted and Transmembrane Wnt Inhibitors and Activators

Cruciat

Niehrs

2012

Cold Spring Harbor Perspectives in Biology

539

450

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Section: Cerberusmentioning

confidence: 99%

Secreted and Transmembrane Wnt Inhibitors and Activators

Cruciat

Niehrs

2012

Cold Spring Harbor Perspectives in Biology

539

450

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“…Morpholino oligonucleotides against XCer (Cer-MO) microinjected in the two dorsal-vegetal blastomeres of the 4-8 cell stage Xenopus embryo, impaired the induction of the head, where a reduction in the primary head and eyes could be observed (Silva et al, 2003;Kuroda et al, 2004). To try to uncover the biological roles of XCer and of the ADE in head formation, we decided to challenge the activity and local requirement of Xcerberus during this process.…”

Section: Cerberus In Anterior-posterior Patterningmentioning

confidence: 99%

Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family

Belo¹,

Silva²,

Borges³

et al. 2009

Int. J. Dev. Biol.

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One fundamental aspect of vertebrate embryonic development is the formation of the body plan. For this process, asymmetries have to be generated during early stages of development along the three main body axes: Anterior-Posterior, Dorso-Ventral and Left-Right. We have been studying the role of a novel class of molecules, the Cerberus/Dan gene family. These are dedicated secreted antagonists of three major signaling pathways: Nodal, BMP and Wnt. Our studies contribute to the current view that the fine tuning of signaling is controlled by a set of inhibitory molecules rather than by activators. In this context, the Cerberus-like molecules emerge as key players in the regulation and generation of asymmetries in the early vertebrate embryo.

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“…The AVE comprises a population of primitive endoderm cells located at the distal tip of the 5.5 dpc (days post coitum) embryo, which undergo differentiation and migration to the prospective anterior region and have been reported to be involved in the establishment of the anterior-posterior (AP) axis (Rossant and Tam, 2004). The process of neural AP patterning involves the integration of various signals such as retinoic acid (RA), fibroblast growth factors (FGF) and members of the Wnt family as well as the inhibition of BMP-4, Nodal and Wnt8 signaling (Piccolo et al, 1999;Glinka et al, 1997;Silva et al, 2003).…”

mentioning

confidence: 99%

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase expression during early mouse embryonic development

Salgueiro¹,

Filipe²,

Belo³

2006

Int. J. Dev. Biol.

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N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) is an enzyme which is known to help build up the GlcAβ1-3GalNAc(4,6-bisSO 4 ) unit of chondroitin sulfate E (CS-E). This enzymatic activity has been reported in squid cartilage and in human serum, but has never been reported as an enzyme required during early mouse development. On the other hand, CS-E has been shown to bind with strong affinity to Midkine (MK). The latter is a heparin-binding growth factor which has been found to play important regulatory roles in differentiation and morphogenesis during mouse embryonic development. We have analyzed the expression pattern of the GalNAc4S-6ST gene during early mouse embryonic development by whole mount in situ hybridization. The results show that GalNAc4S-6ST is differentially expressed in the anterior visceral ectoderm at stage E5.5 and later becomes restricted to the embryonic endoderm, especially in the prospective midgut region. During the turning process, expression of GalNAc4S-6ST gene is detected in the forebrain, branchial arches, across the gut tube (hindgut, midgut and foregut diverticulum), in the vitelline veins and artery and in the splanchnopleure layer. These results open the possibility of a role for GalNAc4S-6ST during early mouse development.

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Endogenous Cerberus activity is required for anterior head specification inXenopus

Cited by 45 publications

References 53 publications

Secreted and Transmembrane Wnt Inhibitors and Activators

Secreted and Transmembrane Wnt Inhibitors and Activators

Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase expression during early mouse embryonic development

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