Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Against Energy Stress

Abstract

Editorial, see p 225Mitochondria are dynamic organelles that constantly undergo fusion and fission 5 to adapt to changes in the cellular environment. Although mitochondrial fusion allows mitochondria to maintain membrane potential by fusing depolarized mitochondria to intact ones, fission allows the segregation of unrecoverable mitochondria so that they can be eliminated by autophagy or mitophagy, a specialized form of autophagy.6 Mitochondrial fusion is critically

DLP1‐dependent mitochondrial fragmentation and redistribution mediate prion‐associated mitochondrial dysfunction and neuronal death

“…Studies demonstrated that suitable mitochondrial fission is required for damaged mitochondria before removal by mitophagy in mouse pancreatic β cells (Twig et al ., 2008). Besides, downregulation of DLP1 has been reported to prevent mitochondrial autophagy in mouse heart (Ikeda et al ., 2015; Shirakabe et al ., 2016). DLP1 has also been described to modulate mitophagy, possibly involving the interaction of DLP1 with the mitophagy receptor FUN14 domain‐containing 1 Pan troglodytes (FUNDC1) (Zuo et al ., 2014; Wu et al ., 2016).…”

Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass

“…An important aspect of this process is mitochondrial turnover, which refers to the integrated processes of degradation via autophagy (mitophagy) and biogenesis. We and others previously demonstrated the importance of cardiac mitophagy in attenuating I/R-induced injury (2)(3)(4). A considerable amount of preclinical evidence that mitochondrial biogenesis programs are activated in the setting of cold cardioplegia or I/R has been reported (reviewed in ref.…”

Methylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy

“…Taken together, MB promotes mitophagy by maintaining the MMP at a relatively high level, which contributes to a decrease in necrosis and an improvement in neurological function, thereby protecting against ACI injury. leads to mitochondrial dysfunction (16,17). Dysfunctional mitochondria can be selectively eliminated via mitophagy (18)(19)(20).…”