Endogenous endophthalmitis in hemoglobin SC disease

Issaivanan, Mph Magimairajan; Ahmed, Rafat S.; Redner, Arlene; Karayalcyn, Gungor; Sood, Sunil K.; Shakin, Jeffrey L.

doi:10.1002/pbc.21895

Cited by 6 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, She also had anemia, which could also be a risk factor for endophthalmitis. [10][11][12][13] Anemia may compromise the immune system and increase the risk of opportunistic infection.…”

Section: Discussionmentioning

confidence: 99%

Bilateral endogenous fungal endophthalmitis: A case report

et al. 2023

View full text Add to dashboard Cite

Rationale: Endogenous fungal endophthalmitis is a challenging condition. There are no universally accepted diagnostic or management protocols. We share a case of endogenous fungal endophthalmitis who was successfully treated, focusing on the diagnostic and treatment procedures. Patient concerns: A 31-year-old female with a history of fungal vaginitis and tinea corporis presented with progressive visual decrease in both eyes after having an induced abortion. Her best corrected visual acuity at presentation was 20/1000 in her right eye and 20/250 in her left eye. Upon slit lamp examination, mild inflammatory reaction in the anterior chamber was found. Dilated fundus examination revealed a hazy view of the optic disc and posterior retina, and there was a whitish mass with “string and pearls” just in front of the macular region in each eye. Diagnoses: Bilateral fungal endogenous endophthalmitis was diagnosed empirically, which was confirmed later by deoxyribonucleic acid sequencing and culture of intraocular fluid. Interventions: Oral itraconazole and intravitreal voriconazole were administered to the patient at first. The intraocular inflammation was partially responsive to the medication, yet the visual acuity persisted to deteriorate and the vitreous whitish masses became more prominent. Then vitrectomy procedures were carried out and oral itraconazle was switched to intravenous fluconazole. The antifungal treatment lasted for 8 weeks. Outcomes: The intraocular inflammation alleviated and visual acuity improved after vitrectomy. At the 9-month follow-up visit, the patient’s best corrected visual acuity was 20/40 in the right eye and 20/30 in the left eye. There was no intraocular inflammatary reaction, and retinal scar was noticed in each eye. Lesson: Early and correct diagnosis, coupled with prompt and aggressive treatment, is crucial for cases of fungal endogenous endophthalmitis. Deoxyribonucleic acid sequencing techniques can contribute to early diagnosis, while vitrectomy may be necessary when antifungal medication is insufficient in controlling the condition.

show abstract

Section: Discussionmentioning

confidence: 99%

Bilateral endogenous fungal endophthalmitis: A case report

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Ocular cultures are negative in 40% of cases; therefore, the diagnosis relies mostly on blood cultures, 12 and, as in our case, on the findings on CT and MRI. 12,19…”

Section: Discussionmentioning

confidence: 99%

Neuroimaging of ocular involvement in patients with sickle cell disease and review of the literature

et al. 2017

View full text Add to dashboard Cite

Endophthalmitis is a rare cause of ocular infection that can be associated with immunocompromising conditions and, more rarely, with sickle cell disease. In this case report and review of the literature, we present a case of a young male with sickle cell disease who presented with rapidly progressive ocular pain, edema, erythema, and decreased visual acuity. The key radiological findings to suggest endophthalmitis were demonstrated using computed tomography and magnetic resonance imaging.

show abstract

Preventing Infections in Sickle Cell Disease: The Unfinished Business

Obaro

Tam

2016

Pediatr Blood Cancer

View full text Add to dashboard Cite

While encapsulated bacterial agents, particularly Streptococcus pneumoniae, are recognized as important microbes that are associated with serious illness in hosts with sickle cell disease (SCD), multiple pathogens are implicated in infectious manifestations of SCD. Variations in clinical practice have been an obstacle to the universal implementation of infection preventive management through active, targeted vaccination of these individuals and routine usage of antibiotic prophylaxis. Paradoxically, in low-income settings, there is evidence that SCD also increases the risk for several other infections that warrant additional infection preventive measures. The infection preventive care among patients with SCD in developed countries does not easily translate to the adoption of these recommendations globally, which must take into account the local epidemiology of infections, available vaccines and population-specific vaccine efficacy, environment, health care behaviors, and cultural beliefs, as these are all factors that play a complex role in the manifestation of SCD and the prevention of infectious disease morbidity.

show abstract

Endogenous endophthalmitis in hemoglobin SC disease

Cited by 6 publications

References 9 publications

Bilateral endogenous fungal endophthalmitis: A case report

Bilateral endogenous fungal endophthalmitis: A case report

Neuroimaging of ocular involvement in patients with sickle cell disease and review of the literature

Preventing Infections in Sickle Cell Disease: The Unfinished Business

Contact Info

Product

Resources

About