Endogenous endophthalmitis secondary to bacterial meningitis from Neisseria Meningitidis: a case report and review of the literature

Balaskas, Konstantinos; Potamitou, Dora

doi:10.1186/1757-1626-2-149

Cited by 16 publications

(11 citation statements)

References 13 publications

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“…Ocular manifestations are similarly inconsistent and may be unilateral 1,4,6-8 or bilateral, 2,3,5 with anterior 6,7 or posterior segment signs, 5,8 or panophthalmitis. 1,2,4,8 Endogenous meningococcal endophthalmitis and may occur in infants, 3 teenagers, 5,6,8 or adults 1,2,4patients are almost universally immunocompetent. [1][2][3][4][5][6][7][8] The variable clinical presentation of meningococcal endophthalmitis presents a diagnostic challenge to both pediatricians and ophthalmologists.…”

Section: Discussionmentioning

confidence: 99%

Neisseria meningitidisEndogenous Endophthalmitis with Meningitis in an Immunocompetent Child

Yusuf

Sipkova

Patel

et al. 2013

Ocular Immunology and Inflammation

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Neisseria meningitidis is a major cause of childhood morbidity and mortality worldwide. We describe an exceptional case of an immunocompetent 15-month-old child presenting with a unilateral anterior uveitis, hypopyon, and sepsis. Anterior chamber aspirate demonstrated gram-negative cocci before Neisseria meningitidis was identified in blood and cerebrospinal fluid. Meningococcal endophthalmitis presents variably with sepsis, meningitis, or isolated ocular symptoms. Diagnosis is a clinical challenge, requiring diagnostic sampling and treatment from both pediatricians and ophthalmologists. Delayed or incorrect treatment risks blindness, disability, or death. Simultaneous invasion of meningococcus across intact blood-brain and blood-ocular barriers in this child suggests antigenic correlates between meningeal and ocular endothelial interfaces. Meningococcus is an exclusively human pathogen; research is hampered by the lack of animal models. This clinical observation suggests the potential of a novel in vitro experimental approach of using ocular tissue from eye banks to further elucidate the meningococcal-endothelial interaction that underpins meningococcal disease.

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Section: Discussionmentioning

confidence: 99%

Neisseria meningitidisEndogenous Endophthalmitis with Meningitis in an Immunocompetent Child

Yusuf

Sipkova

Patel

et al. 2013

Ocular Immunology and Inflammation

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“…Simple conjunctivitis can progress into endophthalmitis, which is accompanied usually by severe pain, loss of vision, and redness of the conjunctiva and the underlying episclera. Meningococcal endophthalmitis presents variably with sepsis [102,112,113,121], meningitis [114,115], or isolated ocular symptoms without systemic illness [112,[116][117][118][119], although subsequent development of other expressions of meningococcal disease should not be ruled out [103][104][105]. Thus, delayed or incorrect treatment of meningococcal ocular infections ultimately risks blindness, disability, or death [120] (Table 1).…”

Section: Meningococcal Ophthalmiamentioning

confidence: 99%

Atypical, Yet Not Infrequent, Infections with Neisseria Species

Humbert

Christodoulides

2019

Pathogens

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Neisseria species are extremely well-adapted to their mammalian hosts and they display unique phenotypes that account for their ability to thrive within niche-specific conditions. The closely related species N. gonorrhoeae and N. meningitidis are the only two species of the genus recognized as strict human pathogens, causing the sexually transmitted disease gonorrhea and meningitis and sepsis, respectively. Gonococci colonize the mucosal epithelium of the male urethra and female endo/ectocervix, whereas meningococci colonize the mucosal epithelium of the human nasopharynx. The pathophysiological host responses to gonococcal and meningococcal infection are distinct. However, medical evidence dating back to the early 1900s demonstrates that these two species can cross-colonize anatomical niches, with patients often presenting with clinically-indistinguishable infections. The remaining Neisseria species are not commonly associated with disease and are considered as commensals within the normal microbiota of the human and animal nasopharynx. Nonetheless, clinical case reports suggest that they can behave as opportunistic pathogens. In this review, we describe the diversity of the genus Neisseria in the clinical context and raise the attention of microbiologists and clinicians for more cautious approaches in the diagnosis and treatment of the many pathologies these species may cause.

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“…20 Many bacteria have been reported to cause endog enous endophthalmitis. Gramnegative agents associated with bacterial endogenous endophthalmitis include Klebsiella pneumoniae, 29 Pseudomonas aeruginosa, 30 Escherichia coli, 31 Enterococcus faecalis, 32 Neisseria meningitidis, 33 Proteus spp., 34 and others. Gramnegative agents associated with bacterial endogenous endophthalmitis include Klebsiella pneumoniae, 29 Pseudomonas aeruginosa, 30 Escherichia coli, 31 Enterococcus faecalis, 32 Neisseria meningitidis, 33 Proteus spp., 34 and others.…”

Section: Endogenous Bacterial Endophthalmitismentioning

confidence: 99%