Endogenous endophthalmitis secondary to pyogenic liver abscess

Al-Amri, Musleh Saleh

doi:10.1016/j.ijdm.2009.12.005

Cited by 3 publications

(6 citation statements)

References 12 publications

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“…For the vitreous samples, 67% were positive for Klebsiella pneumoniae, 22% were negative, and 11% of the results were unavailable [7][8][9][10][11][12]. For the blood samples, only 33% were positive, while 56% of the results were negative and 11% of the results were negative for Klebsiella pneumoniae [7][8][9][10][11][12]. For abscess fluid samples, 45% were positive for Klebsiella pneumoniae, 22% were negative, and 33% of the results were unavailable [7][8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

“…Previously reported cases as shown in Table 1 were treated with a combination of systemic and intravitreal antibiotics in which third-generation cephalosporins, second-generation cephalosporins, aminoglycosides, antifungals, and nitroimidazole were the antibiotics of choice administered [7][8][9][10][11][12]. Pars plana vitrectomy (PPV) was performed in four cases [7][8][9][10]. There were three unfortunate cases were required evisceration despite prompt treatment administered [8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…Both genders were equally affected in previously reported cases. Seven out of nine published cases had underlying diabetes mellitus, while only two cases were non-diabetic and had no other comorbidities [ 7 - 12 ]. Our patient and a patient reported by Correia et al were in the middle-aged group and had no underlying diabetes mellitus [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…In two cases, all cultures were positive for Klebsiella pneumoniae (22%) [ 9 , 11 ], while in the other two cases, all cultures were negative [ 10 , 12 ]. For the vitreous samples, 67% were positive for Klebsiella pneumoniae, 22% were negative, and 11% of the results were unavailable [ 7 - 12 ]. For the blood samples, only 33% were positive, while 56% of the results were negative and 11% of the results were negative for Klebsiella pneumoniae [ 7 - 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…For the blood samples, only 33% were positive, while 56% of the results were negative and 11% of the results were negative for Klebsiella pneumoniae [ 7 - 12 ]. For abscess fluid samples, 45% were positive for Klebsiella pneumoniae , 22% were negative, and 33% of the results were unavailable [ 7 - 12 ].…”

Section: Discussionmentioning

confidence: 99%

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Bilateral Endogenous Klebsiella pneumoniae Endophthalmitis in Culture-Negative Liver Abscess Requiring Evisceration: A Case Report and Review of Literature

Arjamilah¹,

Aiman-Mardhiyyah²,

Shatriah³

et al. 2023

Cureus

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Endogenous endophthalmitis is a very rare but potentially devastating intraocular inflammation resulting from hematogenous dissemination into the eye from a remote focus of infection. We present a case of a 49year-old Vietnamese gentleman with underlying hypertension and ischemic heart disease who presented with sudden onset bilateral eye blurring of vision for five days associated with fever, chills, and rigors. He started to have a chesty cough with right-sided pleuritic chest pain for three days as well as shortness of breath, which developed one day prior to admission. Bilateral ocular examinations and B-scan ultrasonography were consistent with endophthalmitis. A systemic workup was performed and showed multiloculated liver abscess and right lung empyema seen radiologically. Bilateral eye vitreous tap and intravitreal antibiotic injection were performed. He underwent ultrasound-guided pigtail catheter insertion and drainage of the subcapsular and pelvic collection. Microbiological findings revealed Klebsiella pneumoniae infection obtained from vitreous and endotracheal aspirate samples. There were no cultures yielded from the intraabdominal collection and peripheral blood. The right eye infection rapidly progressed to panophthalmitis, which subsequently led to globe perforation despite prompt treatment and eventually required evisceration. Thus, despite culture-negative pyogenic liver abscess in a non-diabetic patient, a high index of suspicion, emergent radiographic evaluation, and prompt intervention and treatment are crucial in salvaging the globes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Bilateral Endogenous Klebsiella pneumoniae Endophthalmitis in Culture-Negative Liver Abscess Requiring Evisceration: A Case Report and Review of Literature

Arjamilah¹,

Aiman-Mardhiyyah²,

Shatriah³

et al. 2023

Cureus

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Endogenous endophthalmitis and liver abscess syndrome secondary due to Klebsiella pneumoniae: report of three cases from Qatar

Ani

Elzouki

Rahil

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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YCG063 inhibits Pseudomonas aeruginosa LPS-induced inflammation in human retinal pigment epithelial cells through the TLR2-mediated AKT/NF-κB pathway and ROS-independent pathways

Paeng

Park

Jung

et al. 2015

International Journal of Molecular Medicine

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Abstract. YCG063 is known as an inhibitor of reactive oxygen species (ROS); however, its intracellular mechanisms of action remain poorly understood. In the present study, we investigated the effects of YCG063 on the inflammatory response of Pseudomonas aeruginosa lipopolysaccharide (PA-LPS)-stimulated human retinal pigment epithelial cells (RPE cells). Human adult RPE cells (ARPE-19) were stimulated with PA-LPS. We then investigated the LPS-induced expression of several inflammatory mediators, such as interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1 (MCP-1) and intracellular adhesion molecule-1 (ICAM-1) in the ARPE-19 cells. We performed an enzyme-linked immunosorbent assay (ELISA), western blot analysis, electrophoretic mobility shift assay (EMSA) and fluorescence-activated cell sorting (FACS) to elucidate the mechanisms involved in the anti-inflammatory effects of YCG063 in the PA-LPS-stimulated cells. The results revealed that treatment with YCG063 significantly inhibited the levels of IL-6, IL-8, MCP-1 and ICAM-1 in the PA-LPS-stimulated ARPE-19 cells. YCG063 also markedly inhibited the phosphorylation of AKT in the PA-LPS-stimulated cells. In addition, the activation of nuclear factor-κB (NF-κB) was also attenuated folllowing treatment with YCG063. ROS were not generated in the PA-LPS-stimulated cells. In conclusion, our data indicate that YCG063 may prove to be a potential protective agent against inflammation, possibly through the downregulation of Toll-like receptor 2 (TLR2) and the AKT-dependent NF-κB activation pathway in PA-LPSstimulated ARPE-19 cells. Furthermore, this anti-inflammatory activity occurred through ROS-independent signaling pathways. IntroductionEndophthalmitis is an uncommon intraocular inflammatory condition, but it may result in partial or complete vision loss. It may occur as a complication of intraocular surgery or as a result of non-surgical trauma or systemic infection (1). Bacterial endophthalmitis is an infection of the intraocular cavities that usually occurs following the introduction of microbial organisms into the eye (2). During a bacterial infection, irreversible damage to the photoreceptor cells of the retina frequently occurs (3). Among the bacterial pathogens, Pseudomonas aeruginosa (PA), a Gram-negative rod rod-shaped organism, is frequently a cause of nosocomial infections (4). PA can cause ocular infections, such as keratitis and endophthalmitis (5). YCG063 inhibits Pseudomonas aeruginosa LPS-induced inflammation in human retinal pigment epithelial cells through the TLR2-mediated AKT/NF-κB pathway and ROS-independent pathways

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Endogenous endophthalmitis secondary to pyogenic liver abscess

Cited by 3 publications

References 12 publications

Bilateral Endogenous Klebsiella pneumoniae Endophthalmitis in Culture-Negative Liver Abscess Requiring Evisceration: A Case Report and Review of Literature

Bilateral Endogenous Klebsiella pneumoniae Endophthalmitis in Culture-Negative Liver Abscess Requiring Evisceration: A Case Report and Review of Literature

Endogenous endophthalmitis and liver abscess syndrome secondary due to Klebsiella pneumoniae: report of three cases from Qatar

YCG063 inhibits Pseudomonas aeruginosa LPS-induced inflammation in human retinal pigment epithelial cells through the TLR2-mediated AKT/NF-κB pathway and ROS-independent pathways

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