Since centuries, medical practice has advanced concomitantly with newer therapeutic and research discoveries which improved markedly physicians' options for treating patients and to prolong human life. In that sense the short length of time from the assumption that there is a substance responsible for regulation of erythropoiesis and creation of human recombinant erythropoietin was amazing. During the seventies, one of the authors (MD) had the "privilege" to study various effects of human urinary erythropoietin which at those times was quite