Endogenous formaldehyde level of foods and its biological significance

Trézl, Lajos; Csiba, A; Juhász, Sándor; Szentgyörgyi, M.; Lombai, G.; Hullán, Lehel; Juhász, Angéla

doi:10.1007/s002170050169

Cited by 35 publications

(30 citation statements)

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“…Although the physiological and pathological functions of endogenous formaldehyde in the brains are not clear until now, formaldehyde is present in the cytoplasm and nucleus of all cells of biological organism [16][17][18][19]. Using fluorescence-HPLC, we found that levels of brain formaldehyde are about 0.2~0.4 mM, similar to levels previously reported using gas chromatography/mass spectrometry [20].…”

Section: Exogenous and Endogenous Factors Induce Formaldehyde Accumulsupporting

confidence: 82%

Urine Formaldehyde: A Non-Invasive Marker for Alzheimer’s Disease?

Tong¹

2017

J Alzheimers Dis Parkinsonism

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Section: Exogenous and Endogenous Factors Induce Formaldehyde Accumulsupporting

confidence: 82%

Urine Formaldehyde: A Non-Invasive Marker for Alzheimer’s Disease?

Tong¹

2017

J Alzheimers Dis Parkinsonism

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“…In meat, background levels of formaldehyde ranged from 2.5 mg/kg in sandwich paste from poultry, 2.9-4.6 mg/kg in cold meat cuts, ham from poultry, turkey, up to 10-20.7 mg/kg in sausages and up to 224-267 mg/kg in the outer layer of smoked ham (Brunn and Klostermeyer, 1984;Trezl et al, 1997).…”

Section: Background Levels Of Formaldehyde In Foodmentioning

confidence: 99%

“…Formaldehyde is present in the milligram range with the lowest level measured in fresh milk (0.013 -< 1 mg/kg) (Kaminski et al 1993;Trezl et al, 1997).…”

Section: Background Levels Of Formaldehyde In Foodmentioning

confidence: 99%

Endogenous formaldehyde turnover in humans compared with exogenous contribution from food sources

2014

EFS2

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The FEEDAP Panel received a request to deliver a scientific opinion on the safety and efficacy of formaldehyde used in feed for all animal species based on dossiers submitted by applicants. In parallel, the ANS Panel evaluated the safety of formaldehyde formed from endogenous production and from dietary sources of methanol, including aspartame. In order to support both evaluations, assistance was requested to the SCER unit to evaluate the oral internal dose of formaldehyde in humans from endogenous production, food-derived from target animals exposed to formaldehyde-treated feed and formaldehyde generated from dietary sources of methanol, including from food additives such as aspartame. Endogenous turnover of formaldehyde was estimated to be approximately 0.61-0.91 mg/kg bw per minute and 878-1310 mg/kg bw per day assuming a half life of 1-1.5 min. Compared with formaldehyde turnover and the background levels of formaldehyde from food sources (1.7-1.4 mg/kg b. w per day for a 60-70 kg person), including from dietary methanol, the relative contribution of exogenous formaldehyde from consumption of animal products (milk, meat) from target animals exposed to formaldehyde-treated feed was negligible (<0.001 %). Oral exposure to formaldehyde from aspartame involves metabolism to methanol and further oxidation to formaldehyde. At the current ADI of 40 mg/kg bw per day for aspartame, formaldehyde would be approximately 4 mg/kg bw per day and represent only 0.3-0.4 % of the endogenous turnover of formaldehyde.

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“…Formaldehyde is present in the cytoplasm and nucleus of all cells (Kalapos 1999;Kalász 2003;Trézl et al 1997;Tyihák et al 1998). Using fluorescence highperformance liquid chromatography (Fluo-HPLC), we have shown that the levels of brain formaldehyde are about 0.2-0.4 mM, similar to the levels previously reported using gas chromatography/mass spectrometry (Heck et al 1982;Tong et al 2011).…”

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confidence: 99%

Accumulated hippocampal formaldehyde induces age-dependent memory decline

Tong

Han

Luo

et al. 2012

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187

151

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Aging is an important factor in memory decline in aged animals and humans and in Alzheimer's disease and is associated with the impairment of hippocampal long-term potentiation (LTP) and downregulation of NR1/NR2B expression. Gaseous formaldehyde exposure is known to induce animal memory loss and human cognitive decline; however, it is unclear whether the concentrations of endogenous formaldehyde are elevated in the hippocampus and how excess formaldehyde affects LTP and memory formation during the aging process. In the present study, we report that hippocampal formaldehyde accumulated in memorydeteriorating diseases such as age-related dementia. Spatial memory performance was gradually impaired in normal Sprague-Dawley rats by persistent intraperitoneal injection with formaldehyde. Furthermore, excess formaldehyde treatment suppressed the hippocampal LTP formation by blocking N-methyl-D-aspartate (NMDA) receptor. Chronic excess formaldehyde treatment over a period of 30 days markedly decreased the viability of the hippocampus and down-regulated the expression of the NR1 and NR2B subunits of the NMDA receptor. Our results indicate that excess endogenous formaldehyde is a critical factor in memory loss in age-related memory-deteriorating diseases.

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Endogenous formaldehyde level of foods and its biological significance

Cited by 35 publications

References 0 publications

Urine Formaldehyde: A Non-Invasive Marker for Alzheimer’s Disease?

Urine Formaldehyde: A Non-Invasive Marker for Alzheimer’s Disease?

Endogenous formaldehyde turnover in humans compared with exogenous contribution from food sources

Accumulated hippocampal formaldehyde induces age-dependent memory decline

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