Endogenous Gammaretrovirus Acquisition in Mus musculus Subspecies Carrying Functional Variants of the XPR1 Virus Receptor

Bamunusinghe, Devinka; Liu, Qingping; Lu, Xiaoyu; Oler, Andrew J.; Kozak, Christine A.

doi:10.1128/jvi.01264-13

Cited by 18 publications

(40 citation statements)

References 54 publications

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“…Bxv1 is a nondefective X-ERV capable of producing infectious virus following chemical or immunological stimulation (54). These two ERVs are both found in the sequenced C57BL genome, and both are also found in the Japanese wild mouse M. m. molossinus (23,55). Bxv1 is the only active X-ERV in most inbred strains of mice (1) and is also thought to be active in Japanese mice (24).…”

Section: Resultsmentioning

confidence: 99%

“…Sources of inbred mouse strains, wild-caught and wild-derived mice, and mouse DNAs were described previously (23). Briefly, DNAs were isolated or obtained from mice maintained in our laboratory or from the randomly bred colonies of M. Potter (National Cancer Institute, Bethesda, MD), The Jackson Laboratory (Bar Harbor, ME), S. Rasheed (University of Southern California, Los Angeles, CA), R. Abe (Naval Medical Research Institute, Bethesda, MD), S. Chattopadhyay and H. Morse III (NIAID, Bethesda, MD), and RIKEN BioResource Center (Ibaraki, Japan), which participates in the National Bio-Resources (28).…”

Section: Virusesmentioning

confidence: 99%

“…Thus, X-ERVs are restricted to the Eurasian subspecies M. musculus castaneus, M. m. musculus, and M. m. molossinus, whereas the western European Mus musculus domesticus carries only P-ERVs (22). The classical strains of laboratory mice acquired their MLV ERVs from their wild mouse progenitors, and, in fact, the various Xmv insertions found in the sequenced laboratory mouse genome are also found in Asian wild mice (23). Some of these wild mouse Xmv proviruses are functional (24), and wild mouse P-ERVs can contribute to the production of recombinant P-MLVs that resemble those from laboratory mice (25).…”

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confidence: 99%

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Sequence Diversity, Intersubgroup Relationships, and Origins of the Mouse Leukemia Gammaretroviruses of Laboratory and Wild Mice

Bamunusinghe

Naghashfar

Buckler-White

et al. 2016

J Virol

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Mouse leukemia viruses (MLVs) are found in the common inbred strains of laboratory mice and in the house mouse subspecies of Mus musculus. Receptor usage and envelope (env) sequence variation define three MLV host range subgroups in laboratory mice: ecotropic, polytropic, and xenotropic MLVs (E-, P-, and X-MLVs, respectively). These exogenous MLVs derive from endogenous retroviruses (ERVs) that were acquired by the wild mouse progenitors of laboratory mice about 1 million years ago. We analyzed the genomes of seven MLVs isolated from Eurasian and American wild mice and three previously sequenced MLVs to describe their relationships and identify their possible ERV progenitors. The phylogenetic tree based on the receptor-determining regions of env produced expected host range clusters, but these clusters are not maintained in trees generated from other virus regions. Colinear alignments of the viral genomes identified segmental homologies to ERVs of different host range subgroups. Six MLVs show close relationships to a small xenotropic ERV subgroup largely confined to the inbred mouse Y chromosome. env variations define three E-MLV subtypes, one of which carries duplications of various sizes, sequences, and locations in the proline-rich region of env. Outside the env region, all E-MLVs are related to different nonecotropic MLVs. These results document the diversity in gammaretroviruses isolated from globally distributed Mus subspecies, provide insight into their origins and relationships, and indicate that recombination has had an important role in the evolution of these mutagenic and pathogenic agents. IMPORTANCELaboratory mice carry mouse leukemia viruses (MLVs) of three host range groups which were acquired from their wild mouse progenitors. We sequenced the complete genomes of seven infectious MLVs isolated from geographically separated Eurasian and American wild mice and compared them with endogenous germ line retroviruses (ERVs) acquired early in house mouse evolution. We did this because the laboratory mouse viruses derive directly from specific ERVs or arise by recombination between different ERVs. The six distinctively different wild mouse viruses appear to be recombinants, often involving different host range subgroups, and most are related to a distinctive, largely Y-chromosome-linked MLV ERV subtype. MLVs with ecotropic host ranges show the greatest variability with extensive inter-and intrasubtype envelope differences and with homologies to other host range subgroups outside the envelope. The sequence diversity among these wild mouse isolates helps define their relationships and origins and emphasizes the importance of recombination in their evolution. Mouse leukemia viruses (MLVs) with ecotropic, xenotropic, and polytropic host ranges (E-MLVs, X-MLVs, and P-MLVs, respectively) are readily isolated from the classical strains of the laboratory mouse (reviewed in reference 1). E-MLVs can infect murine cells but not cells of heterologous species; these viruses use the amino acid transporter, CAT-...

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Section: Resultsmentioning

confidence: 99%

Section: Virusesmentioning

confidence: 99%

mentioning

confidence: 99%

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Sequence Diversity, Intersubgroup Relationships, and Origins of the Mouse Leukemia Gammaretroviruses of Laboratory and Wild Mice

Bamunusinghe

Naghashfar

Buckler-White

et al. 2016

J Virol

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“…Terrestrial boreoeutherians, marsupials, and birds Marine and terrestrial boreoeutherians, marsupials, birds, reptiles, and amphibians (Anai et al, 2012;Bamunusinghe et al, 2013;Bolisetty et al, 2012;Elleder et al, 2012;Fiebig et al, 2006;Hanger et al, 2000;Jaratlerdsiri et al, 2009;Lamere et al, 2009;Martin et al, 1999;Patience et al, 2001;Tarlinton et al, 2013;Tristem et al, 1996;Wang et al, (Bertsch et al, 2009;Gayral et al, 2008;Iskra-Caruana et al, 2010;Kunii et al, 2004;Staginnus and Richert-Pöggeler, 2006) Furthermore, there is also a tendency for non-agriculturally and medically important viruses to be overlooked. As a result, it could thus be that the actual viral host range is much broader than surveillance of existing viruses alone could reveal.…”

Section: Boreoeutheriansmentioning

confidence: 99%

Endogenous viruses: Connecting recent and ancient viral evolution

2015

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The rapid rates of viral evolution allow us to reconstruct the recent history of viruses in great detail. This feature, however, also results in rapid erosion of evolutionary signal within viral molecular data, impeding studies of their deep history. Thus, the further back in time, the less accurate the inference becomes. Furthermore, reconstructing complex histories of transmission can be challenging, especially where extinct viral lineages are concerned. This problem has been partially solved by the discovery of viruses embedded in host genomes, known as endogenous viral elements (EVEs). Some of these endogenous viruses are derived from ancient relatives of extant viruses, allowing us to better examine ancient viral host range, geographical distribution and transmission routes. Moreover, our knowledge of viral evolutionary timescales and rate dynamics has also been greatly improved by their discovery, thereby bridging the gap between recent and ancient viral evolution.

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“…T6, T77, and T103, which promote Xpr1 protein expression, were homologous. Xpr1 induces apoptosis after binding to heterophil (Bamunusinghe et al, 2013) or polytropic retrovirus in humans. This result suggested that T6 induces senescence and apoptosis of black locust flower organs after retrovirus infection.…”

Section: Tdfs Related To Senescencementioning

confidence: 99%

Transcriptional profiles of emasculated flowers of black locust (Robinia pseudoacacia) determined using the cDNA-AFLP technique

Sun

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Black locust (Robinia pseudoacacia) is a tree in the subfamily Faboideae, native to North America, that has been naturalized and widely planted in temperate Europe and Asia. Black locust has important ecological and economic value, but its quality needs improvement. Hybridization programs are important for black locust breeding, but the low rate of fruit set after controlled pollination limits both its breeding and that of other monoclinous plant species that share this problem. In this study, we investigated gene expression in emasculated black locust flowers using the cDNA-amplified fragment length polymorphism technique to determine why the rate of fruit set is low after controlled pollination. Flowers that were emasculated after being frozen in liquid nitrogen were used as controls. Changes in the flower transcriptome were more dramatic at 5 h after emasculation than at 48 h. Injury caused by emasculation decreased the expression levels of genes associated with metabolism, growth regulation, signal transduction, and photosynthesis, and it increased the expression of genes related to stress-response metabolism, signal transduction, and promotion of senescence. The changes in the expression levels of these genes had negative effects on sugar metabolism, protein metabolism, lipid metabolism, energy metabolism, matter transport, signal transduction, osmotic regulation, pH regulation, and photosynthesis. Thus, emasculation accelerated flower senescence, resulting in low fruit set.

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Endogenous Gammaretrovirus Acquisition in Mus musculus Subspecies Carrying Functional Variants of the XPR1 Virus Receptor

Cited by 18 publications

References 54 publications

Sequence Diversity, Intersubgroup Relationships, and Origins of the Mouse Leukemia Gammaretroviruses of Laboratory and Wild Mice

Sequence Diversity, Intersubgroup Relationships, and Origins of the Mouse Leukemia Gammaretroviruses of Laboratory and Wild Mice

Endogenous viruses: Connecting recent and ancient viral evolution

Transcriptional profiles of emasculated flowers of black locust (Robinia pseudoacacia) determined using the cDNA-AFLP technique

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