Endogenous Ligands for Nuclear Receptors: Digging Deeper

Schupp, Michael; Lazar, Mitchell A.

doi:10.1074/jbc.r110.182451

Cited by 155 publications

(129 citation statements)

References 100 publications

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“…Since the realization that PPAR ␥ plays a pivotal role in adipocyte development, several attempts have been made to identify the agonists activating PPAR ␥ during adipogenesis ( 37 ). Shortly after the cloning of PPAR ␥ , a derivative of arachidonic acid, 15-deoxy-⌬ 12,14 -prostaglandin J2, was suggested to be the endogenous ligand orchestrating adipose conversion ( 38,39 ).…”

Section: Discussionmentioning

confidence: 99%

PPARγ ligand production is tightly linked to clonal expansion during initiation of adipocyte differentiation

Hallenborg

Petersen

Feddersen

et al. 2014

Journal of Lipid Research

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Section: Discussionmentioning

confidence: 99%

PPARγ ligand production is tightly linked to clonal expansion during initiation of adipocyte differentiation

Hallenborg

Petersen

Feddersen

et al. 2014

Journal of Lipid Research

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“…75 Of these nutrient-responsive transcription factors, the peroxisome proliferator-activated receptor (PPAR) family has been particularly well studied. 76,77 As lipid-responsive genes, with effects on lipoprotein metabolisms and inflammation, the PPARs have been recognized and extensively studied for their relevance to cardiometabolic disease.…”

Section: Candidate Gene Studiesmentioning

confidence: 99%

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment

Ferguson¹,

Allayee²,

Gerszten³

et al. 2016

Circ Cardiovasc Genet

101

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Abstract-Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple "omic" measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome. Here, we describe the current state of the field of nutrigenomics with respect to cardiometabolic disease research and outline a direction for the integration of multiple omics techniques in future nutrigenomic studies aimed at understanding mechanisms and developing new therapeutic options for cardiometabolic disease treatment and prevention. The interpretation and scope of nutrigenomics may vary, but it can be thought to encompass the spectrum of nutritional genomics research, including classic nutrigenetics studies of gene-diet interactions and molecular nutrition, in vitro and in vivo models, human nutrition studies, and the application of largescale, unbiased studies using high-throughput "omics" techniques to study the effects of nutrients on the body. 6 As the Figure shows, diet and the genome may influence cardiometabolic health through a variety of interconnected intermediates, perturbations in which can be measured through omics technologies, including RNA expression (transcriptome), epigenetic modifications (epigenome), metabolites (metabolome), lipids (lipidome), proteins (proteome), and resident microbial communities (microbiome). Although it is clear that both nutrients and genes play a distinct role in determining health, the complex interactions among genes, diet, and downstream networks are not well understood. The application of nutrigenomics approaches to questions of human health and disease is an important component in understanding the complexities of the interplay between basic metabolic processes and externalThe American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This statement was approved by the American Heart Association Science Advisory and Coordinating Committee on January 22, 2016, and the American Heart Association Executive Committee on February 23, 2016. A copy of the document is available at http://professional.heart.org/statements by using either "Search for Guidelines & Statements" or the "Browse by Topic" area. To purchase additional reprints, call 843-216-2533 or e-mail kelle.ramsay@ wolterskluwer.com.The...

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“…Such structural specificity is also likely to extend to endogenous PPAR and RXR agonists. 13 The contact between a PPAR or RXR ligand and its cognate receptor's LBD induces a conformational change in the AF2 domain, facilitating the recruitment of coactivators, like CBP or p300, and release of corepressors, like nuclear receptor corepressor (NCoR) or SMRT. The assembly of these accessory molecules is a key determinant of a nuclear receptor's transcriptional activity.…”

Section: General Biology Of the Ppar/rxr Transcriptional Regulatory Cmentioning

confidence: 99%

The PPAR-RXR Transcriptional Complex in the Vasculature

Plutzky

2011

Circulation Research

137

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Key Words: atherosclerosis Ⅲ diabetes Ⅲ PPARs Ⅲ RXRs Ⅲ gene expression E nergy balance is a fundamental necessity and, as such, is relevant to many disciplines. In physics, energy balance considers energy flow and transformation across different states. Engineering studies energy balance in closed systems, like an automobile, and the distance traveled for the fuel consumed. In geophysics, the energy required to extract a fuel from the earth is set against the energy that fuel yields. For nations and their economies, the energy available is balanced against rates of consumption and cost. Arguably, biology provides the most fundamental context for energy balance: survival, which is predicated on obtaining, using, and storing energy resources. From this perspective, it is striking that the increasingly prevalent chronic diseases facing industrial countries, namely obesity, diabetes, dyslipidemia, and atherosclerosis, are either characterized or defined by abnormalities of energy resources.Original

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Endogenous Ligands for Nuclear Receptors: Digging Deeper

Cited by 155 publications

References 100 publications

PPARγ ligand production is tightly linked to clonal expansion during initiation of adipocyte differentiation

PPARγ ligand production is tightly linked to clonal expansion during initiation of adipocyte differentiation

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment

The PPAR-RXR Transcriptional Complex in the Vasculature

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