Endogenous lipid (cholesterol) pneumonia associated with bronchogenic carcinoma in a cat

Jerram, Richard M.; Guyer, Cheryl; Braniecki, A; Read, W. K.; Hobson, H. Phil

doi:10.5326/15473317-34-4-275

Cited by 21 publications

(19 citation statements)

References 13 publications

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“…In the feline species, reports of extracranial CGs have been described [7,8,28], but only one description of an intracranial CG has been recorded in an old cat [3]. The lesion developed in the longitudinal cerebral fissure and showed histopathological features very similar to the case of our report.…”

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confidence: 80%

Intracranial Cholesterol Granuloma in a Cat

Ricci

Abbiati²,

Cantile

2010

The Journal of Veterinary Medical Science

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ABSTRACT. A case of intracranial cholesterol granuloma is described in a 4-year-old neutered European male cat presented with a 5-month history of progressive weakness, ataxia and depression. On clinical evaluation, haematological and biochemical profiles revealed only mild hypercholesterolemia and magnetic resonance imaging showed a large space-occupying extra-axial mass in the area of the falx, not homogeneous after contrast enhancement. At post-mortem examination, an orange-yellowish mass of 22 mm in diameter extended from the right frontal lobe to the temporo-parietal region, causing atrophy of the prosencephalic region of the brain. The site of origin of the mass was within the subarachnoid space of the supracallosum sulcus of the right cerebral hemisphere. Histological examination of the lesion revealed abundant deposits of cholesterol clefts, surrounded by clusters of macrophages and multinucleated giant cells. Neither inflammatory lesions, nor cholesterol deposits were detected in other areas of the brain and in other organs. On the basis of the histological examination, a diagnosis of intracranial cholesterol granuloma was made.KEY WORDS: cholesterol granuloma, feline, MRI, nervous system disease.J. Vet. Med. Sci. 72(11): 1475-1478, 2010 Cholesterol granulomas (CGs) are known as well circumscribed, non neoplastic lesions, resulting from a chronic inflammatory reaction to continuous deposition of cholesterol crystals [10]. In human beings, a diagnosis of CG has been established in several sites throughout the body, comprising the intracranial localisation [4,13,20].In veterinary medicine, the development of an intracranial cholesterol granuloma has been described as an incidental, asymptomatic finding at necropsy in 20% of older horses and the choroid plexus of fourth and lateral ventricles represented the preferential location of the so-called "cholesteatoma of the choroid plexus" [9]. Sporadic descriptions of identical intracranial lesions have been reported in other animals, such as meerkats (Suricata suricatta sp., family Herpestidae) [2,21,22] A 4 year-old neutered male cat was presented at the "Malpensa" Veterinary Clinic (Samarate, Italy) with a 5-month history of progressive weakness, ataxia and depression. The cat was previously treated with prednisone with partial remission of clinical signs. On clinical examination, the cat appeared dehydrated and in poor general condition. At presentation the cat exhibited aggressive behaviour and only a limited number of neurological tests could be performed. Neurological examination revealed proprioceptive deficits in all four limbs, no evident abnormality of cranial nerves and a poor bilateral menace reaction. On the basis of the clinical data, a forebrain lesion was suspected. Differential diagnoses included encephalitis, neoplasia, toxic, metabolic or nutritional encephalopathy. Haematological and biochemical profiles revealed moderate hyperglycaemia (343 mg/dl, normal range: 60-175 mg/dl) and mild hypercholesterolemia (236 mg/dl, normal range: 97-207 mg...

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confidence: 80%

Intracranial Cholesterol Granuloma in a Cat

Ricci

Abbiati²,

Cantile

2010

The Journal of Veterinary Medical Science

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“…Lipoid pneumonia has occasionally been described in veterinary medicine . Endogenous lipoid pneumonia was reported in domestic and wild animals . In some of the cases, the endogenous lipoid pneumonia was classified as idiopathic .…”

Section: Discussionmentioning

confidence: 99%

Lipoid pneumonia in an orangutan (Pongo abelii) with chronic respiratory problems

Novacco

Hofmann‐Lehmann

Hetzel

et al. 2018

J of Medical Primatology

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An orangutan (Pongo abelii) presented with chronic respiratory problems. Cytological evaluation of the bronchoalveolar lavage fluids revealed macrophages with wellcircumscribed intracytoplasmic clear vacuoles and lipid droplets in the background, confirmed by Oil Red O staining. The findings were indicative of lipoid pneumonia.This is the first report of lipoid pneumonia in an orangutan. K E Y W O R D Sfat attenuation, lipid staining, lipoid pneumonia, orangutan, zoo

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“…Differential diagnoses for these radiographic abnormalities include granulomatous disease (eg, histoplasmosis), pneumonia, pulmonary edema, and endogenous lipid pneumonia. Although causes of primary lung tumors in cats are unknown, a preneoplastic condition seems to be endogenous lipid pneumonia 4. Often the diagnosis is made at necropsy.…”

Section: Discussionmentioning

confidence: 99%

Bronchogenic adenocarcinoma in a cat: an unusual case of metastasis to the skin

Petterino

Guazzi

Ferro

et al. 2005

Veterinary Clinical Pathol

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A 6-year-old, spayed, female, domestic shorthair cat was presented for decreased activity. A nodular lesion was found in the skin extending into the subcutaneous tissue of the right abdominal flank. On lateral and ventrodorsal radiographs of the thorax, an opacity involving the entire right caudal lung lobe and pleural effusion were noted. Cytologic evaluation of cells in the thoracic fluid and in the mass revealed a population of atypical epipthelial cells with marked anisocytosis and high N:C ratios, organized in acinar-like clusters. Multinucleated cells and several mitotic figures were found. The cytologic interpretation was carcinoma. Because of the progressive severity of clinical signs, the cat was euthanized. Histologic evaluation of tissues obtained at necropsy indicated a bronchogenic adenocarcinoma in the lung, with metastasis to the skin of the right flank, but no involvement of the digits. Based on immunohistochemical stains, the neoplastic cells strongly co-expressed cytokeratin and vimentin, and were negative for S-100 and actin-specific antigen. Bronchogenic adenocarcinoma is an uncommon neoplasm in cats, and the digits are the most common sites of metastasis. This case was unusual in that the skin of the abdominal wall was the primary site of metastasis, with no involvement of the digits.

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Endogenous lipid (cholesterol) pneumonia associated with bronchogenic carcinoma in a cat

Cited by 21 publications

References 13 publications

Intracranial Cholesterol Granuloma in a Cat

Intracranial Cholesterol Granuloma in a Cat

Lipoid pneumonia in an orangutan (Pongo abelii) with chronic respiratory problems

Bronchogenic adenocarcinoma in a cat: an unusual case of metastasis to the skin

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