Endogenous microRNA sponges: evidence and controversy

Thomson, Daniel; Dinger, Marcel E.

doi:10.1038/nrg.2016.20

Cited by 1,746 publications

(1,409 citation statements)

References 149 publications

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“…The mechanism of the ceRNA network was that all types of RNA transcripts could communicate with each other by competing for binding to shared MREs [23]. Some lncRNAs could be considered ceRNAs because they could serve as miRNA "sponges" that inhibit interaction with their miRNA targets in post-transcriptional regulation.…”

Section: Discussion Cerna Network In the Endometrium Of Dairy Goatsmentioning

confidence: 99%

WITHDRAWN: Endometrial epithelial cell apoptosis is inhibited via a ciR8073-miR181a-neurotensis pathway during embryo implantation

Zhang¹,

Liu²,

Liu³

et al. 2018

Oncotarget

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Development of receptive endometrium (RE) from pre-receptive endometrium (PE) is essential for embryo implantation, but the molecular mechanisms are not fully understood. In this study, lncRNA/circRNA-miRNA-mRNA networks were constructed to explore the functions of potential competing endogenous RNAs (ceRNA) during the development of RE in dairy goats. We observed that circRNA8073 (ciR8073) decreased levels of miR-181a by acting as a miRNA sponge. This effect indirectly increased expression of neurotensin in endometrial epithelial cells (EECs). Neurotensin in turn inhibited EEC apoptosis by increasing expression of BCL-2/BAX via the MAPK pathway, and also increased expression leukemia-inhibitory factor, cyclo-oxygenase 2, vascular endothelial growth factor A and homeobox A10. We have thus identified a ciR8073-miR181a-neurotensin pathway in the endometrium of dairy goats. Via this pathway, ciR8073 functions as a ceRNA that sequesters miR-181a, thereby protecting neurotensin transcripts from miR-181a-mediated suppression in EECs.

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Section: Discussion Cerna Network In the Endometrium Of Dairy Goatsmentioning

confidence: 99%

WITHDRAWN: Endometrial epithelial cell apoptosis is inhibited via a ciR8073-miR181a-neurotensis pathway during embryo implantation

Zhang¹,

Liu²,

Liu³

et al. 2018

Oncotarget

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“…4,5 The aberrant expression of miRNA and LncRNA was found to be involved into the progression of cancer. [6][7][8][9] miR-34 and let-7 were found to be tumoursuppressive miRNAs in lung cancer, systemic nano-delivery of miR-34…”

mentioning

confidence: 99%

miR‐193b availability is antagonized by LncRNA‐SNHG7 for FAIM2‐induced tumour progression in non‐small cell lung cancer

et al. 2017

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Objectives: Long non-coding RNAs have identified to involve into the tumour cell proliferation, apoptosis and metastasis. We previously found that up-regulated LncRNA-SNHG7 (SNHG7) positively correlated to the Fas apoptosis inhibitory molecule 2 (FAIM2) in lung cancer cells with unclear mechanism.Methods: Non-small cell lung cancer (NSCLC) and relative normal tissues (n = 25) were collected. The SNHG7 expression and function in NSCLC was determined. The SNHG7-miR 193b-FAIM2 network was analysed in vitro and vivo.Results: We reported that oncogene SNHG7 predicted a poor clinical outcome and functioned as competitive endogenous RNA (ceRNA) antagonized microRNA-193b Conclusion:The results indicated that miR-193b is indispensible for the ceRNA role of SNHG7 in FAIM2-supported tumourigenesis of lung cancer.

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“…This represents another layer of microRNA regulation in human cancer, with changes in the function but not expression of a microRNA. The debate on the physiological relevance of ceRNA concept is summarized in a recent excellent review [55].…”

Section: Aberrant Microrna Expression In Human Cancermentioning

confidence: 99%

Non-coding RNAs: the cancer genome dark matter that matters!

Ling¹,

Girnita

Buda

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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Protein-coding genes comprise only 3% of the human genome, while the genes that are transcribed into RNAs but do not code for proteins occupy majority of the genome. Once considered as biological darker matter, non-coding RNAs are now being recognized as critical regulators in cancer genome. Among the many types of non-coding RNAs, microRNAs approximately 20 nucleotides in length are best characterized and their mechanisms of action are well generalized. microRNA exerts oncogenic or tumor suppressor function by regulation of protein-coding genes via sequence complementarity. The expression of microRNA is aberrantly regulated in all cancer types, and both academia and biotech companies have been keenly pursuing the potential of microRNA as cancer biomarker for early detection, prognosis, and therapeutic response. The key involvement of microRNAs in cancer also prompted interest on exploration of therapeutic values of microRNAs as anticancer drugs and drug targets. MRX34, a liposome-formulated miRNA-34 mimic, developed by Mirna Therapeutics, becomes the first microRNA therapeutic entering clinical trial for the treatment of hepatocellular carcinoma, renal cell carcinoma, and melanoma. In this review, we presented a general overview of microRNAs in cancer biology, the potential of microRNAs as cancer biomarkers and therapeutic targets, and associated challenges.

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Endogenous microRNA sponges: evidence and controversy

Cited by 1,746 publications

References 149 publications

WITHDRAWN: Endometrial epithelial cell apoptosis is inhibited via a ciR8073-miR181a-neurotensis pathway during embryo implantation

WITHDRAWN: Endometrial epithelial cell apoptosis is inhibited via a ciR8073-miR181a-neurotensis pathway during embryo implantation

miR‐193b availability is antagonized by LncRNA‐SNHG7 for FAIM2‐induced tumour progression in non‐small cell lung cancer

Non-coding RNAs: the cancer genome dark matter that matters!

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