Endogenous neuropeptides in patients with acute traumatic head injury II: Changes in the levels of cerebrospinal fluid substance P, serotonin and lipid peroxidation products in patients with head trauma

Karaküçük, E Inci; Paşaoğlu, Hatîce; Paşaoğlu, Aydın; Öktem, Suat

doi:10.1016/s0143-4179(97)90057-3

Cited by 11 publications

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Biomarkers of cognitive dysfunction in traumatic brain injury

Sun

Feng

2013

J Neural Transm

View full text Add to dashboard Cite

Acetylcholine, glutamate, dopamine, serotonin (5-HT), gamma-aminobutyric acid, substance P (SP), amyloid-β (Aβ) and neurotrophic protein S100B are arguably the most important cognition-related biomarkers in the brain. Among this list are five neurotransmitters that signal through postsynaptic receptors. Our knowledge of cognition-related biomarkers has been advanced through translational experiments and clinical case-study data. Although these biomarkers are widespread in the brain and pronounced individual variations exist, these biomarkers can be used to identify both acute and chronic abnormalities following traumatic brain injury. Changes in these biomarkers likely indicate damage to brain networks or to key brain cell types that support cognitive functions. Identification of such biomarker abnormalities could result in earlier diagnoses, improved prognoses and therapies that enable neurotransmitters to return to normal levels.

show abstract

Biomarkers of cognitive dysfunction in traumatic brain injury

Sun

Feng

2013

J Neural Transm

View full text Add to dashboard Cite

show abstract

Pharmacotherapy to enhance arousal: what is known and what is not

Zafonte

Hammond

Dennison

et al. 2009

Progress in Brain Research

View full text Add to dashboard Cite

Factors contributing to attentional impairments after traumatic brain injury.

et al. 2009

View full text Add to dashboard Cite

The aim of the present study was to investigate the contribution of impaired information processing speed and strategic control of attention to performance on attentional tasks after traumatic brain injury (TBI). Forty moderately to severely injured rehabilitation inpatients and 40 healthy controls completed a selection of attentional tasks. Slowed processing speed in the TBI group was identified on the Symbol Digit Modalities Test (SDMT), 2&7 Selective Attention Test (2&7), Selective Attention (SAT), and Four Choice Reaction Time (4CRT) tasks. Impaired working memory was evident on the Letter Number Sequencing (LNS) task. Structural equation modeling revealed that the group difference in RT on the complex SAT was accounted for by slowed speed of processing on the simple SAT, and not working memory. TBI participants made more errors and missed responses on the complex version of the SAT, suggesting impairment in some aspects of strategic control of attention, and appeared unable to benefit from the automatic condition of the 2&7 Test. There was little evidence of deficit on the Sustained Attention to Response Task (SART). The present study provides evidence for a significant contribution of slowed processing speed to impaired performance on attentional tasks after TBI.

show abstract

Endogenous neuropeptides in patients with acute traumatic head injury II: Changes in the levels of cerebrospinal fluid substance P, serotonin and lipid peroxidation products in patients with head trauma

Cited by 11 publications

References 32 publications

Biomarkers of cognitive dysfunction in traumatic brain injury

Biomarkers of cognitive dysfunction in traumatic brain injury

Pharmacotherapy to enhance arousal: what is known and what is not

Factors contributing to attentional impairments after traumatic brain injury.

Contact Info

Product

Resources

About