Endogenous oestradiol but not testosterone is related to coronary artery disease in men

Sá, Emmanuela Quental Callou de; Sá, Francisco Carleial Feijó de; Silva, Rebeca de Souza e; Oliveira, Kelly Cristina de; Guedes, Alexis Dourado; Feres, Fausto; Verreschi, Ieda Therezinha do Nascimento

doi:10.1111/j.1365-2265.2011.04017.x

Cited by 23 publications

(25 citation statements)

References 51 publications

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“…In contrast, Callou de Sá et al reported an association between increased E2 and coronary artery disease 36. Obviously, cross-sectional studies do not provide information on causality.…”

Section: Discussionmentioning

confidence: 94%

Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies

Vandenplas

Bacquer

Fiers

et al. 2012

Heart

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14 studies out of 128 electronically identified articles were eligible. Data to be used for meta-analysis could be calculated in seven cases, and in the remaining seven cases, data of three more became available by contacting those authors. Overall, a non-significant association was found with an estimated summary RR of 0.98 for a change of >75th versus <25th percentile in E2 (95% CI 0.74 to 1.31). Mean body mass index (BMI) of the study population (βs -0.8, p<0.004), and quality of E2 assay (βs -0.6, p<0.08) may have modified the relationship between E2 and incident CVD. The present systematic review does not provide evidence for a pronounced harmful or beneficial effect of E2 on risk for incident CVD in healthy men. If present, an effect of E2 on risk for CVD might be modulated by BMI.

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“…In contrast, Callou de Sá et al reported an association between increased E2 and coronary artery disease 36. Obviously, cross-sectional studies do not provide information on causality.…”

Section: Discussionmentioning

confidence: 94%

Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies

Vandenplas

Bacquer

Fiers

et al. 2012

Heart

View full text Add to dashboard Cite

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“…A case can be made to develop clinical algorithms incorporating accurate measurement of E 2 as part of the evaluation of osteoporosis in men. Moreover, recent epidemiologic studies in men and women have demonstrated associations between low sex hormone concentrations (including E 2 ) and the risk of cardiovascular disease in both sexes (16,17,28,29), suggesting another indication where more reliable methods for E 2 measurement should be used. It should be acknowledged that in everyday clinical practice, the higher concentrations of E 2 in men that may occur in gynecomastia and the rare cases of feminising tumors and aromatase excess can be discriminated with sufficient accuracy by IA.…”

Section: Discussionmentioning

confidence: 99%

“…Although E 2 measurements are less often required for men, high concentrations are of diagnostic importance in gynecomastia and the rare cases of feminizing tumors and aromatase excess (13). Low E 2 concentrations are important in the assessment of osteoporosis (14,15) and cardiovascular diseases (16,17), where the replacement of IAs with more specific and sensitive MS measurements is expected to be useful.…”

Section: Introductionmentioning

confidence: 99%

Comparison of serum testosterone and estradiol measurements in 3174 European men using platform immunoassay and mass spectrometry; relevance for the diagnostics in aging men

Huhtaniemi

Tajar

Lee

et al. 2012

European Journal of Endocrinology

175

120

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Background: The limitations of serum testosterone and estradiol (E 2 ) measurements using nonextraction platform immunoassays (IAs) are widely recognized. Switching to more specific mass spectrometry (MS)-based methods has been advocated, but directly comparative data on the two methods are scarce. Methods: We compared serum testosterone and E 2 measurements in a large sample of middle-aged/elderly men using a common platform IA and a gas chromatography (GC)-MS method, in order to assess their limitations and advantages, and to diagnose male hypogonadism. Of subjects from the European Male Aging Study (nZ3174; age 40-79 years), peripheral serum testosterone and E 2 were analyzed using established commercial platform IAs (Roche Diagnostics E170) and in-house GC-MS methods. Results: Over a broad concentration range, serum testosterone concentration measured by IA and MS showed high correlation (RZ0.93, P!0.001), which was less robust in the hypogonadal range (!11 nmol/l; RZ0.72, P!0.001). The IA/MS correlation was weaker in E 2 measurements (RZ0.32, P!0.001, at E 2 !40.8 pmol/l, and RZ0.74, P!0.001, at E 2 O40.8 pmol/l). Using MS as the comparator method, IA ascertained low testosterone compatible with hypogonadism (!11 nmol/l), with 75% sensitivity and 96.3% specificity. The same parameters with IA for the detection of low E 2 (!40.7 pmol/l) were 13.3 and 99.3%, and for high E 2 (O120 pmol/l) 88.4 and 88.6%. Conclusion: A validated platform IA is sufficient to detect subnormal testosterone concentrations in the diagnosis of male hypogonadism. The IA used for E 2 measurements showed poor correlation with MS and may only be suitable for the detection of high E 2 in men.

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“…Although both male and female sex hormones have been well-documented to be able to influence vascular biology and to play an important role in coronary artery disease 3-5,34-37, the steroid theory was not echoed by other studies. Yang found that 2D:4D ratios, measures of masculine characteristics, and salivary testosterone showed no significant associations with one another in both male and female 18.…”

Section: Discussionmentioning

confidence: 99%

The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population

Wu¹,

Yang²,

Chai³

et al. 2013

Int. J. Med. Sci.

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Background: The association between index finger to ring finger length ratio (2D:4D) and cardiac disorders has been reported, however it has not been discussed in terms of coronary artery disease (CAD). We investigated whether 2D:4D could be used as a marker for predisposition to CAD as assessed by coronary angiography in Chinese men and women.Methods: This study included 1764 persons divided into 4 groups, 441 cases with CAD and 441 persons without CAD as control in each sex of the same age. Finger lengths were measured twice for both hands using electronic calipers. Student t test was used to detect the difference of 2D:4D among groups. The receiver operator characteristic curves (ROCs) were used to detect the diagnostic effect of 2D:4D for CAD.Results: There were no significant differences in age among the four groups. A significant difference of 2D:4D ratios between right and left hand were observed only in men in both control and CAD groups. On the right hand in the control group and on both hands in the CAD group, the 2D:4D ratios were higher in women than in men (all, P < 0.001). In men with CAD, mean 2D:4D was higher than mean 2D:4D in control men (right hand 0.962±0.042:0.927±0.038; left hand 0.950±0.044:0.934±0.048; both hands, P < 0.001), but this was not observed in women. No relationship was found between 2D:4D and age (all, P >0.05). The area under the curve of right hand 2D:4D in male was 0.72 (95% CI 0.683-0.753, p<0.001), while it was 0.602 (95% CI 0.565-0.639, p<0.001) in left hand.Conclusions: The present study showed an association between high 2D:4D ratio and CAD in both hands in men. There were no significant differences in mean 2D:4D between women with CAD and controls.

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Endogenous oestradiol but not testosterone is related to coronary artery disease in men

Abstract: In this study, men with CAD had higher oestradiol and FEI levels. Additional studies are needed to clarify the direction of causality and possible underlying mechanisms.

Cited by 23 publications

References 51 publications

Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies

Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies

Comparison of serum testosterone and estradiol measurements in 3174 European men using platform immunoassay and mass spectrometry; relevance for the diagnostics in aging men

The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population

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