Endogenous opioid signalling regulates spinal ependymal cell proliferation

Yue, Wendy W. S.; Touhara, Kouki K.; Toma, Kenichi; Duan, Xin; Julius, David

doi:10.1038/s41586-024-07889-w

Nature

2024

DOI: 10.1038/s41586-024-07889-w

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Endogenous opioid signalling regulates spinal ependymal cell proliferation

Wendy W. S. Yue,

Kouki K. Touhara,

Kenichi Toma

et al.

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Spinal cerebrospinal fluid contacting neurons are a conserved sensory neuronal population along the mouse spinal cord

Elysa,

Edith,

Jorge

et al. 2024

Preprint

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Cerebrospinal Fluid contacting neurons (CSF-cNs) are present in all vertebrates around the medullo-spinal central canal. They are GABAergic, selectively express PKD2L1, a member of the TRP channel superfamily, and are thought to represent a novel sensory system intrinsic to the central nervous system. Using histology, we found that CSF-cNs form a homogeneous population, distributed along the whole spinal cord and mainly located in the ventral region of the central canal. Patch-clamp recordings reveal conserved intrinsic properties and voltage-dependent conductance expression. Spinal CSF-cNs express PKD2L1 channels and ASICs, acting as sensory receptors for extracellular pH changes. They express both inhibitory (GABAA, glycine) and excitatory (glutamate, cholinergic) synaptic receptors as well as functional GABAB and muscarinic receptors, but not glutamatergic metabotropic ones, to modulate Ca2+ channels. CSF-cNs represent a functionally homogeneous population that might integrates sensory signals along the central canal to modulate body functions by regulating local spinal networks. Demonstrating such a function represents the future challenge in the field.

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Spinal cerebrospinal fluid contacting neurons are a conserved sensory neuronal population along the mouse spinal cord

Elysa,

Edith,

Jorge

et al. 2024

Preprint

View full text Add to dashboard Cite

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Endogenous opioid signalling regulates spinal ependymal cell proliferation

Cited by 1 publication

References 50 publications

Spinal cerebrospinal fluid contacting neurons are a conserved sensory neuronal population along the mouse spinal cord

Spinal cerebrospinal fluid contacting neurons are a conserved sensory neuronal population along the mouse spinal cord

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