Endogenous panophthalmitis with orbital cellulitis secondary to <i><scp>E</scp>scherichia coli</i>

Papakostas, Thanos D.; Lee, Grace; Lefebvre, Daniel R.; Barshak, Miriam Baron; Freitag, Suzanne K.

doi:10.1111/ceo.12094

Cited by 12 publications

(4 citation statements)

References 4 publications

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“…In contrast, our study found that panophthalmitis was a significant risk factor for ENEV. In various case reports and short series on the management of panophthalmitis, evisceration and enucleation are the most common outcomes [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. In another study of endogenous panophthalmitis, 9 out of 15 patients had had an evisceration; 5 of them had had prior intravitreal treatment that could not control their infection [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors Leading to Enucleation or Evisceration in Infectious Endophthalmitis

Merly¹,

Toledo²,

Figueroa³

et al. 2022

JCM

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Endophthalmitis treatment consists of intravitreal antibiotics injections and, in selected circumstances, pars plana vitrectomy. However, severe or refractory cases may require an enucleation or evisceration (ENEV). Our study seeks to identify risk factors leading to enucleation or evisceration in patients with infectious endophthalmitis. A retrospective chart review of subjects with a clinical diagnosis of infectious endophthalmitis was undertaken. The affected eyes were stratified into groups: those that underwent ENEV and those in which the eyeball was preserved (EP). The groups were compared using statistical analyses. In total, 69 eyes diagnosed with infectious endophthalmitis were included in the study. There was a higher frequency of exogenous infectious endophthalmitis in the ENEV group versus the EP group. Postsurgical infectious endophthalmitis was lower in the ENEV than in the EP group. A visual acuity of no light perception was more common in the ENEV compared to the EP group. Panophthalmitis was more frequent in the ENEV versus the EP group. Our findings suggest that eyes with endophthalmitis presenting with a visual acuity of no light perception, panophthalmitis, or exogenous etiology have a higher risk of requiring ENEV. In addition, eyes with a postsurgical etiology may be at a lower risk of requiring ENEV.

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Section: Discussionmentioning

confidence: 99%

Risk Factors Leading to Enucleation or Evisceration in Infectious Endophthalmitis

Merly¹,

Toledo²,

Figueroa³

et al. 2022

JCM

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“…Simultaneous endogenous endophthalmitis and orbital cellulitis has been reported in only a few cases with Escherichia coli 8 and Pseudomonas aeruginosa , 9 although isolated endogenous endophthalmitis is much more common. It is likely that the bacteria seeded both the retinal and orbital vessels in our cases.…”

Section: Discussionmentioning

confidence: 99%

Endogenous Serratia marcescens panophthalmitis: A case series

Breazzano

Jonna

Nathan

et al. 2019

American Journal of Ophthalmology Case Reports

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Purpose – Two rare and unusual cases of endogenous panophthalmitis from Serratia marcescens are presented with mechanisms for infection explored. Observations – The first patient had history of intravenous drug use (IVDU) without any medical implants. The second patient, in addition to IVDU, had a history of end-stage renal disease with upper extremity arteriovenous fistula graft infection from Serratia marcescens confirmed by wound culture. One patient had a history of licking the needles prior to IV drug injection. Clinical exam in both cases revealed light perception vision, relative afferent pupillary defect, periorbital edema with limited extraocular motility, and hypopyon in the affected eyes. Cultures from the anterior chamber aspirate were positive for Serratia marcescens in the first case and demonstrated Gram-negative rods in the second. Attempted vitreous aspiration was unsuccessful at obtaining specimens. Computed tomography demonstrated orbital fat stranding without abscess, and histopathology showed intense neutrophilic infiltration in all layers of enucleated specimen in case one. Conclusions and Importance Needle licking may be an underappreciated mechanism for endogenous endophthalmitis in intravenous drug users. This report includes the first case in the literature, to authors’ knowledge, of non-nosocomial endogenous Serratia marcescens panophthalmitis with orbital cellulitis. The second case illustrates a rare consequence of the rise in arteriovenous fistula placement and dialysis across the United States, which may predispose to future cases of endogenous Serratia marcescens endophthalmitis. This series supports previous observations of Serratia marcescens endogenous endophthalmitis exhibiting a generally poor visual prognosis.

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“…[1][2][3] It is known to have a very poor visual prognosis, 1-3 requiring early diagnosis and aggressive treatment in an attempt to preserve vision and prevent spreading to surrounding tissues, such as the orbit and cavernous sinus. 4 Despite treatment, the infection is often rapidly progressive and evisceration or enucleation of the eye is a common end result. 1,2 We report an unusual case in which systemic investigations and multiple aqueous and vitreous cultures failed to identify a causative microorganism for presumed endogenous endophthalmitis.…”

mentioning

confidence: 99%

Chorioretinal Biopsy for the Diagnosis of Endogenous Endophthalmitis Due to Escherichia Coli

Cheng

Chandra

Roufail³

et al. 2017

RETINAL Cases &Amp; Brief Reports

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Endogenous panophthalmitis with orbital cellulitis secondary to Escherichia coli

Cited by 12 publications

References 4 publications

Risk Factors Leading to Enucleation or Evisceration in Infectious Endophthalmitis

Risk Factors Leading to Enucleation or Evisceration in Infectious Endophthalmitis

Endogenous Serratia marcescens panophthalmitis: A case series

Chorioretinal Biopsy for the Diagnosis of Endogenous Endophthalmitis Due to Escherichia Coli

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