Endogenous PMN-derived reactive oxygen intermediates provide feedback regulation on respiratory burst signal transduction

Derevianko, A.; D’Amico, Ronald; Graeber, Thomas G.; Keeping, Hugh S.; Simms, Henry S.

doi:10.1002/jlb.62.2.268

Cited by 26 publications

(13 citation statements)

References 35 publications

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“…Specifically, catalase is predominantly located in cellular peroxisomes and converts hydrogen peroxides to water and oxygen. 15 The present study found that catalase was significantly lower in the PE group than in the HP and NP groups, an observation compatible with the results of previous investigations. 29,30 Antioxidant nutrient levels can be manipulated simply by dietary or pharmacological supplements.…”

Section: Discussionsupporting

confidence: 93%

“…14 Superoxide dismutase (SOD) and catalase are effective scavengers for detoxification of radicals: SOD catalyses the convertion of superoxide into oxygen and hydrogen peroxide, and catalase is an antioxidant enzyme that is predominantly located in cellular peroxisomes and converts hydrogen peroxide to water and oxygen. 15 Serum or placental zinc (Zn) concentrations have been reported to be low in pre-eclamptic women. 16 For Cu as with Zn, there is however considerable inconsistency in results concerning the relationship between maternal plasma concentrations and pre-eclampsia.…”

Section: Introductionmentioning

confidence: 99%

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Catalase Activity, Serum Trace Element and Heavy Metal Concentrations, and Vitamin A, D and E Levels in Pre-Eclampsia

et al. 2008

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Catalase (antioxidant enzyme) activity in erythrocytes and serum levels of trace elements (copper, iron, zinc), heavy metals (cadmium, cobalt) and vitamins A (retinol), D (cholecalciferol) and E (atocopherol) were measured in 145 subjects comprising 47 pre-eclamptic pregnant women (PE), 48 healthy pregnant women (HP) and 50 healthy non-pregnant controls (NP). Catalase, vitamins A, D and E and levels of cobalt were significantly lower in the PE group compared with the HP and NP groups, whereas levels of copper, iron and cadmium were significantly higher in the PE group than in the HP and NP groups. Levels of zinc were significantly lower in both the PE and HP groups compared with the NP group. This assessment of oxidant/ antioxidant imbalance in pregnant women could be useful in the early identification of pre-eclampsia and antioxidant supplementation in the early weeks of gestation might be useful.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Catalase Activity, Serum Trace Element and Heavy Metal Concentrations, and Vitamin A, D and E Levels in Pre-Eclampsia

et al. 2008

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“…Moreover, agents that activate oxidative and adhesive pathways concomitantly inhibit chemotactic responses of PMNs in vitro [161][162][163]. Assembly and activation of NADPH oxidase in PMNs alters intracellular redox status [164], and endogenous oxidants produced in activated PMNs can act as signal transduction factors that modulate kinase activity [148,165] and gene expression. Thus, it is tempting to conclude that chemotaxis and oxidant-associated functions in PMN are mutually exclusive and determined by the redox state of the cell.…”

Section: Pmn Primingmentioning

confidence: 99%

Neutrophil migration during endotoxemia

Wagner

Roth

1999

Journal of Leukocyte Biology

177

125

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Endotoxemia is marked by a global activation of inflammatory responses, which can lead to shock, multiple organ failure, and the suppression of immune and wound healing processes. Neutrophils (PMNs) play a central role in some of these responses by accumulating in tissues and releasing reactive oxygen species and proteases that injure host structures. This review focuses on altered PMN migratory responses that occur during endotoxemia and their consequences in the development of pulmonary infection. The inflammatory mediators that might be responsible for these altered responses are discussed. The oxidant potential of PMNs is increased after exposure to endotoxin both in vitro and during clinical and experimental endotoxemia. However, other functions such as chemotaxis and phagocytosis are often depressed in these same cells. Endotoxin exposure renders PMNs hyperadhesive to endothelium. The sum of these effects produces activated inflammatory cells that are incapable of leaving the vasculature. As such, the endotoxic PMN is more likely to promote tissue injury from within microvascular beds than to clear pathogens from extravascular sites. Moreover, the functional characteristics of endotoxic PMNs are similar to those observed during trauma, burn injury, sepsis, surgery, and other inflammatory conditions. Accordingly, several clinical conditions might have a common effector in the activated, yet migratorially dysfunctional, PMN. Direct effects of endotoxin on PMNs as well as effects of endogenous mediators released during endotoxemia are discussed. Understanding PMN behavior during endotoxemia may provide basic and critical insights that can be applied to a number of inflammatory scenarios. J. Leukoc. Biol. 66: 10-24; 1999.

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“…As mature neutrophils are likely to be involved in stem cell mobilization, functional signal transduction pathways may be an important step in the activation of neutrophils and subsequent granule release. In this regard, it was recently reported that reactive oxygen intermediates (ROIs) are important as second messengers in the signal transduction of neutrophils (Derevianko et al, 1997). Thus, the production of ROIs could be instrumental in the release of the content of granules, including metalloproteinases that may be necessary for the rapid mobilization of stem cells from the bone marrow into the blood.…”

mentioning

confidence: 99%

Respiratory burst of neutrophils is not required for stem cell mobilization in mice

Robinson

Drukteinis

et al. 2000

Br J Haematol

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It has been suggested that mature neutrophils may play an essential role in the cascade of events leading to egress of stem cells from the bone marrow to the peripheral blood. To investigate further the role of mature neutrophils and of reactive oxygen intermediates (ROIs), known to be involved in the signal transduction of neutrophils, we used mice deficient in respiratory burst, and thus the production of ROIs, to study the involvement of this activation pathway in stem cell mobilization. B6 mice with chronic granulomatous disease (CGD) received either cyclophosphamide (200 mg/kg) on day 1 and granulocyte colony‐stimulating factor (G‐CSF) (250 µg/kg/d) on days 3–6 or a single dose of interleukin 8 (IL‐8; 30 µg/mouse) as a mobilization regimen. On day 7, the number of stem and progenitor cells in blood and bone marrow was compared with control B6 animals (with intact respiratory burst). White blood cell counts, bone marrow cellularity and the frequency of granulocyte–macrophage colony‐forming cells (GM‐CFC), and cobblestone area‐forming cells (CAFC) on days 7 (CAFC‐7) and 28 (CAFC‐28) were determined. After cyclophosphamide and G‐CSF (CY + G), both mouse strains showed considerable mobilization of CAFC‐7 and CFU‐GM to the blood. Normal mice showed up to a 1905‐fold increase in progenitors per ml blood, whereas CGD mice showed up to a 264‐fold increase in blood progenitors. IL‐8 also induced mobilization in both mouse strains. In addition to progenitors, primitive stem cells measured as CAFC‐28 and as CAFC at day 35 were also mobilized by both mobilization protocols in normal as well as in CGD mice. In conclusion, respiratory burst and the subsequent signal transduction pathway do not appear to be required for mobilization of stem cells. Accordingly, neutrophils either are not involved in stem cell mobilization or other signalling pathways within neutrophils must exist that lead to the release of factors which activate stem cell egress from the bone marrow.

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Endogenous PMN-derived reactive oxygen intermediates provide feedback regulation on respiratory burst signal transduction

Abstract: Abstract:The role ofpolymorphonuclear leukocytes (PMN) in stemming systemic infection is executed mainly by the utilization of molecular 02 leading to

Cited by 26 publications

References 35 publications

Catalase Activity, Serum Trace Element and Heavy Metal Concentrations, and Vitamin A, D and E Levels in Pre-Eclampsia

Catalase Activity, Serum Trace Element and Heavy Metal Concentrations, and Vitamin A, D and E Levels in Pre-Eclampsia

Neutrophil migration during endotoxemia

Respiratory burst of neutrophils is not required for stem cell mobilization in mice

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