Endogenous regulation of mosquito host-seeking behavior by a neuropeptide

Brown, Mark R.; Klowden, Marc J.; Crim, Joe W.; Young, Larry L.; Shrouder, Lisa A.; Lea, Arden O.

doi:10.1016/0022-1910(94)90158-9

Cited by 96 publications

(92 citation statements)

References 35 publications

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“…If the blood meal suffices to trigger egg production, the humoral mechanism is activated ['oocyte-induced inhibition' (Klowden and Lea, 1979b)], where different organs are involved, such as the ovary, fat body and neurosecretory cells. Concerning the physiological mechanism, it has been shown in Aedes aegypti that the response of lactic acid olfactory receptors is inhibited by humoral factors present in the haemolymph after feeding (Brown et al, 1994). It is worth comparing our present results revealed in R. prolixus with those obtained in mosquitoes.…”

Section: The Physiological Mechanismssupporting

confidence: 61%

Behavioural and physiological state dependency of host seeking in the blood-sucking insectRhodnius prolixus

Bodin

Vinauger

Lazzari

2009

Journal of Experimental Biology

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SUMMARYVertebrate blood is essential for the growth and the reproduction of haematophagous insects. Provided that hosts play the double role of food sources and predators, feeding on their blood exposes these insects to a high predation risk. Therefore, it is expected that host seeking occurs only when insects need to feed. In the present study, we analyse how the feeding status affects the response to host-associated cues in the blood-sucking insect Rhodnius prolixus. We show that the responsiveness to hostassociated cues, such as CO 2 and heat, and that the motivation to feed depend on the time elapsed since a blood meal. Depending on the time elapsed after feeding, the same concentration of CO 2 may attract or repel the insects. As far as we know, this is the first time that a host signal has been shown to be repellent for a haematophagous insect. The response to heat is also modulated but no repellence was observed. When blood was replaced by saline solution as food, a significant reduction of the response to both signals was evinced but repellence was not observed. The injection of haemolymph from fed insects into starved insects inhibited the response of the receiver insects to both signals but this was not observed after the injection of saline solution or of haemolymph from non-fed insects. This is the first time that the modulation of feeding behaviour by the feeding status has been analysed in a hemimetabolous blood-sucking insect, fully excluding any effect of other processes, such as reproduction.

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Section: The Physiological Mechanismssupporting

confidence: 61%

Behavioural and physiological state dependency of host seeking in the blood-sucking insectRhodnius prolixus

Bodin

Vinauger

Lazzari

2009

Journal of Experimental Biology

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“…29). In these studies, significant reductions in olfactory responses have been observed after ingestion of a blood meal, and are postulated to involve mechanisms resulting from the effects of both abdominal distension (30) and the ovarian-and fat body-mediated release of a neuropeptide from the central nervous system (31). Furthermore, electrophysiological recordings have been used to measure changes at the chemosensory level in A. aegypti, showing reductions in sensitivity to lactic acid in peripheral olfactory neurons after a blood meal (32).…”

Section: Resultsmentioning

confidence: 99%

Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding

Fox

Pitts

Robertson

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

216

178

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Olfaction plays a major role in host preference and blood feeding, integral behaviors for disease transmission by the malaria vector mosquito Anopheles gambiae sensu stricto (henceforth A. gambiae). We have identified four genes encoding candidate odorant receptors from A. gambiae that are selectively expressed in olfactory organs, contain approximately seven transmembrane domains, and show significant similarity to several putative odorant receptors in Drosophila melanogaster. Furthermore, one of the putative A. gambiae odorant receptors exhibits female-specific antennal expression and is down-regulated 12 h after blood feeding, a period during which substantial reduction in olfactory responses to human odorants has been observed. Taken together, these data suggest these genes encode a family of odorant receptors in A. gambiae, whose further study may aid in the design of novel antimalarial programs.

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“…These effects are exactly the opposite as the previously mentioned effects seen in D. melanogaster and A. mellifera (Ament et al 2011;Root et al 2011). When female A. aegypti were injected with Head Peptide I (Aea-HP-I, the first identified sNPF), host seeking behaviour was inhibited (Brown et al 1994). Interestingly, the hemolymph titre of this sNPF seems to rise after a blood meal, corresponding with the period of the naturally occurring inhibition of host seeking behaviour (Brown et al 1994).…”

Section: Neuropeptide F and Short Neuropeptide Fmentioning

confidence: 87%

Peptidergic control of food intake and digestion in insects¹This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era.

et al. 2012

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Like all heterotrophic organisms, insects require a strict control of food intake and efficient digestion of food into nutrients to maintain homeostasis and to fulfill physiological tasks. Feeding and digestion are steered by both external and internal signals that are transduced by a multitude of regulatory factors, delivered either by neurons innervating the gut or mouthparts, or by midgut endocrine cells. The present review gives an overview of peptide regulators known to control feeding and digestion in insects. We describe the discovery and functional role in these processes for insect allatoregulatory peptides, diuretic hormones, FMRFamide-related peptides, (short) neuropeptide F, proctolin, saliva production stimulating peptides, kinins, and tachykinins. These peptides control either gut myoactivity, food intake, and (or) release of digestive enzymes. Some peptides exert their action at multiple levels, possibly having a biological function that depends on their site of delivery. Many regulatory peptides have been physically extracted from different insect species. However, multiple peptidomics, proteomics, transcriptomics, and genome sequencing projects have led to increased discovery and prediction of peptide (precursor) and receptor sequences. In combination with physiological experiments, these large-scale projects have already led to important steps forward in unraveling the physiology of feeding and digestion in insects.Key words: insect, midgut, digestion, neuropeptides, stomatogastric nervous system. Résumé : Comme tous les organismes hétérotrophes, les insectes requièrent un contrôle strict de leur ingestion de nourriture et la digestion de leur nourriture en nutriments afin de maintenir leur homéostasie et de compléter leurs tâches physiologiques. L'alimentation et la digestion sont gouvernées par des signaux tant externes qu'internes qui sont transmis par un multitude de facteurs régulateurs, livrés ou bien par les neurones qui innervent le tube digestif ou les pièces buccales ou alors par les cellules endocrines du tube digestif moyen. Notre revue fournit une synthèse des régulateurs peptidiques connus pour contrôler l'alimentation et la digestion chez les insectes. Nous décrivons la découverte et le rôle fonctionnel de ces processus dans le cas des peptides allatorégulateurs, des hormones diurétiques, des peptides apparentés aux amides FMRF, du neuropeptide F (court), de la proctoline, des peptides stimulateurs de la production de salive, des kinines et des tachykinines des insectes. Ces peptides contrôlent la myoactivité du tube digestif, l'ingestion de nourriture et(ou) la libération des enzymes digestives. Certains peptides agissent à de multiples niveaux, possédant une fonction biologique qui dépend de leur site d'action. Plusieurs peptides régulateurs ont été extraits physiquement de différentes espèces d'insectes. Cependant, plusieurs projets de peptidomique, de protéomique, de transcriptomique et de génomique ont mené à de nombreuses découvertes supplémentaires et des prédict...

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Endogenous regulation of mosquito host-seeking behavior by a neuropeptide

Cited by 96 publications

References 35 publications

Behavioural and physiological state dependency of host seeking in the blood-sucking insectRhodnius prolixus

Behavioural and physiological state dependency of host seeking in the blood-sucking insectRhodnius prolixus

Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding

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