Endogenous retinoids in the hair follicle and sebaceous gland

Everts, Helen B.

doi:10.1016/j.bbalip.2011.08.017

Cited by 55 publications

(49 citation statements)

References 144 publications

(150 reference statements)

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“…• Retinoids, the metabolism of which in this specific region has now been better analyzed, and the role of vitamin deficiency in comedogenesis revisited [12,13]…”

Section: The Entry Of Naïve Sebaceous Glands Into the Acne Cycle: Thementioning

confidence: 99%

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Strategic Targets in Acne: The Comedone Switch in Question

Saurat¹

2015

Dermatology

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The sequence of events and mechanisms leading to the development of the primary acne lesion, the comedone, is revisited. Recent knowledge obtained both from lineage tracing experiments in the mouse and the pilosebaceous response to xenobiotics in humans provides robust models for further understanding key biological events at the cellular roots of comedogenesis. The focus is set on the LRIG1+ sebaceous stem cells in the isthmus of the pilosebaceous duct. The master switch that transforms a normally functioning sebaceous gland into a microcomedone and the hierarchy of factors involved in this process are reviewed. The key strategic target in acne care appears to be the naïve pilosebaceous follicle that is not involved yet in the acne cycle. The prevention of the comedone switch implies that the key switching factors are adequately controlled in the long term.

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“…• Retinoids, the metabolism of which in this specific region has now been better analyzed, and the role of vitamin deficiency in comedogenesis revisited [12,13]…”

Section: The Entry Of Naïve Sebaceous Glands Into the Acne Cycle: Thementioning

confidence: 99%

“…Therefore comedogenic factors may alter the process on vitamin A metabolism, thereby inducing vitamin A deficiency [12]. …”

Section: The Entry Of Naïve Sebaceous Glands Into the Acne Cycle: Thementioning

confidence: 99%

Strategic Targets in Acne: The Comedone Switch in Question

Saurat¹

2015

Dermatology

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“…Keratin deposition in the cells gradually increases as the cells are pushed towards the outer layers of the skin, finally the cells become non-viable, dead cells pile up over one another and are pushed out of the body in the form of hair and nails. Saturation of the body with vitamins, especially vitamin A [61,62] , vitamin E [63][64][65] , Omega three fatty acids [66] become pro oxidant, interfere with keratinisation leading to non-creation of hair keratinized cells ultimately manifesting as hair loss instead of hair growth.…”

Section: Dht Can Be Blocked By Antioxidantsmentioning

confidence: 99%

Controlled clinical trial for evaluation of hair growth with low dose cyclical nutrition therapy in men and women without the use of finasteride

Rajput¹

2017

PAR

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“…A frequent adverse effect of these therapies is RA-induced hair loss [62,80]. The mechanisms to explain how excess RA arrests hair follicle growth have been explored [27,62].…”

Section: Development Of Skin In Retinoid Signaling Deficient Micementioning

confidence: 99%

Retinoic Acid-Induced Epidermal Transdifferentiation in Skin

Akimoto

Miyaji

Morimoto-Kamata

et al. 2014

JDB

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Retinoids function as important regulatory signaling molecules during development, acting in cellular growth and differentiation both during embryogenesis and in the adult animal. In 1953, Fell and Mellanby first found that excess vitamin A can induce transdifferentiation of chick embryonic epidermis to a mucous epithelium (Fell, H.B.; Mellanby, E. Metaplasia produced in cultures of chick ectoderm by high vitamin A. J. Physiol. 1953, 119, 470-488). However, the molecular mechanism of this transdifferentiation process was unknown for a long time. Recent studies demonstrated that Gbx1, a divergent homeobox gene, is one of the target genes of all-trans retinoic acid (ATRA) for this transdifferentiation. Furthermore, it was found that ATRA can induce the epidermal transdifferentiation into a mucosal OPEN ACCESS J. Dev. Biol. 2014, 2 159 epithelium in mammalian embryonic skin, as well as in chick embryonic skin. In the mammalian embryonic skin, the co-expression of Tgm2 and Gbx1 in the epidermis and an increase in TGF-β2 expression elicited by ATRA in the dermis are required for the mucosal transdifferentiation, which occurs through epithelial-mesenchymal interaction. Not only does retinoic acid (RA) play an important role in mucosal transdifferentiation, periderm desquamation, and barrier formation in the developing mammalian skin, but it is also involved in hair follicle downgrowth and bending by its effect on the Wnt/β-catenin pathway and on members of the Runx, Fox, and Sox transcription factor families.

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Endogenous retinoids in the hair follicle and sebaceous gland

Cited by 55 publications

References 144 publications

Strategic Targets in Acne: The Comedone Switch in Question

Strategic Targets in Acne: The Comedone Switch in Question

Controlled clinical trial for evaluation of hair growth with low dose cyclical nutrition therapy in men and women without the use of finasteride

Retinoic Acid-Induced Epidermal Transdifferentiation in Skin

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