Endogenous sex hormones and cognitive function in older women

Koyama, Alain; Tworoger, Shelley S.; Eliassen, A. Heather; Okereke, Olivia I.; Weisskopf, Marc G.; Rosner, Bernard; Yaffe, Kristine; Grodstein, Francine

doi:10.1016/j.jalz.2015.12.010

Cited by 25 publications

(19 citation statements)

References 38 publications

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“…Estrogen replacement therapy is widely used to reduce cognitive deficits in menopausal women [63]. Koyama et al [64] showed a positive correlation between higher plasma estrogen and better cognitive performance. These results suggest that sex hormones might play a role in the sexual dimorphism of chronic pain-associated cognitive deficits observed in our study.…”

Section: Discussionmentioning

confidence: 99%

Sexual dimorphism in cognitive disorders in a murine model of neuropathic pain

et al. 2020

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Background: A sex-difference in susceptibility to chronic pain is well-known. Although recent studies have begun to reveal the sex-dependent mechanisms of nerve injury-induced pain sensitization, sex differences in the affective and cognitive brain dysfunctions associated with chronic pain have not been investigated. Therefore, we tested whether chronic pain leads to affective and cognitive disorders in a mouse neuropathic pain model and whether those disorders are sexually dimorphic. Methods: Chronic neuropathic pain was induced in male and female mice by L5 spinal nerve transection (SNT) injury. Pain sensitivity was measured with the von Frey test. Affective behaviors such as depression and anxiety were assessed by the forced swim, tail suspension, and open field tests. Cognitive brain function was assessed with the Morris water maze and the novel object location and novel object recognition tests. Results: Mechanical allodynia was induced and maintained for up to 8 weeks after SNT in both male and female mice. Depressive-and anxiety-like behaviors were observed 8 weeks post-SNT injury regardless of sex. Chronic paininduced cognitive deficits measured with the Morris water maze and novel object location test were seen only in male mice, not in female mice. Conclusions: Chronic neuropathic pain is accompanied by anxiety-and depressive-like behaviors in a mouse model regardless of sex, and male mice are more vulnerable than female mice to chronic pain-associated cognitive deficits.

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Section: Discussionmentioning

confidence: 99%

Sexual dimorphism in cognitive disorders in a murine model of neuropathic pain

et al. 2020

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“…Presence of sex differences on multi-compound scores was sometimes reported in the literature [73], but not systematically [56]. Proposed mechanisms to explain sex effect might involve hormonal differences [74], genetic factors, differences in brain networks, socioeconomic roles, and health choices [75].…”

Section: Discussionmentioning

confidence: 99%

Cognitive efficiency in late midlife is linked to lifestyle characteristics and allostatic load

Narbutas

Egroo

Chylinski

et al. 2019

Aging

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We investigated whether cognitive fitness in late midlife is associated with physiological and psychological factors linked to increased risk of age-related cognitive decline. Eighty-one healthy late middle-aged participants (mean age: 59.4 y; range: 50-69 y) were included. Cognitive fitness consisted of a composite score known to be sensitive to early subtle cognitive change. Lifestyle factors (referenced below as cognitive reserve factors; CRF) and affective state were determined through questionnaires, and sleep-wake quality was also assessed through actimetry. Allostatic load (AL) was determined through a large range of objective health measures. Generalized linear mixed models, controlling for sex and age, revealed that higher cognitive reserve and lower allostatic load are related to better cognitive efficiency. Crystallized intelligence, sympathetic nervous system functioning and lipid metabolism were the only sub-fields of CRF and AL to be significantly associated with cognition. These results show that previous lifestyle characteristics and current physiological status are simultaneously explaining variability in cognitive abilities in late midlife. Results further encourage early multimodal prevention programs acting on both of these modifiable factors to preserve cognition during the aging process.

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“…In the literature, several studies have identified associations between baseline DHEA(S) levels and cognitive function, although the direction of the association may differ depending on the population studied and the measures used. In an epidemiologic cohort study, older women with higher plasma DHEA(S) levels were found to be at increased odds of reporting subjective cognitive concerns, whereas in patients with bipolar disorder, serum DHEAS levels were found to be inversely correlated with verbal memory . In contrast, male cancer survivors with lower DHEAS levels were found to perform worse on the attention measure in a cross‐sectional study .…”

mentioning

confidence: 94%

Prechemotherapy Levels of Plasma Dehydroepiandrosterone and Its Sulfated Form as Predictors of Cancer‐Related Cognitive Impairment in Patients with Breast Cancer Receiving Chemotherapy

et al. 2019

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Study Objective Dehydroepiandrosterone ( DHEA ) and its sulfated form ( DHEAS )—jointly referred to as DHEA (S)—are neurosteroids known to regulate brain development and function that have been found to be positively correlated with cognitive function. It is unknown whether prechemotherapy plasma DHEA (S) levels are associated with the onset of cancer‐related cognitive impairment ( CRCI ). The objective of this study was to evaluate whether an association exists between prechemotherapy plasma DHEA (S) levels and onset of CRCI in patients with breast cancer receiving chemotherapy. Design Multicenter, prospective cohort study. Setting Two specialized cancer centers in Singapore. Patients Eighty‐one patients with early‐stage breast cancer (stages I– III ) who had no prior exposure to chemotherapy and/or radiotherapy and were scheduled to receive anthracycline‐based or taxane‐based chemotherapy treatment with curative intent. Measurements and Main Results Patients completed assessments for self‐perceived and objective cognitive function at three time points: prechemotherapy (T1), during chemotherapy (T2), and after chemotherapy (T3). Plasma samples were collected prior to chemotherapy, and DHEA (S) levels were quantified by using ultra–high‐performance liquid chromatography–tandem mass spectrometry. Multivariable logistic regression was used to adjust for clinically important factors and to evaluate the association between prechemotherapy plasma DHEA (S) levels and CRCI . Mean ± SD age was 48.9 ± 9.3 years, with 27.8% of patients experiencing clinically significant cognitive impairment based on global Functional Assessment of Cancer Therapy–Cognitive Function scores. The mean ± SD prechemotherapy plasma DHEAS and DHEA levels were 1.61 ± 0.91 μmol/L and 19.21 ± 13.13 nmol/L, respectively. Prechemotherapy DHEAS levels were found to be associated with impairment in the self‐perceived cognitive domains of verbal fluency (adjusted odds ratio [ OR ] 0.27, 95% confidence interval [ CI ] 0.08–0.96) and mental acuity (adjusted OR 0.25, 95% CI 0.08–0.74). Conversely, DHEA levels were not associated with impairment in any cognitive subdomains. Conclusion Our findings suggest that patients with higher prechemotherapy DHEAS levels had lower odds of developing self‐perceived cognitive impai...

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Endogenous sex hormones and cognitive function in older women

Cited by 25 publications

References 38 publications

Sexual dimorphism in cognitive disorders in a murine model of neuropathic pain

Sexual dimorphism in cognitive disorders in a murine model of neuropathic pain

Cognitive efficiency in late midlife is linked to lifestyle characteristics and allostatic load

Prechemotherapy Levels of Plasma Dehydroepiandrosterone and Its Sulfated Form as Predictors of Cancer‐Related Cognitive Impairment in Patients with Breast Cancer Receiving Chemotherapy

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