Endogenous sex steroids and circulating homocysteine in healthy Greek postmenopausal women

Christodoulakos, George; Lambrinoudaki, Ιrene; Rizos, Demetrios; Alexandrou, Andreas; Kountouris, A.; Creatsas, George

doi:10.14310/horm.2002.11166

Cited by 8 publications

(7 citation statements)

References 35 publications

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“…Also, the ovarian steroid (estradiol) showed significant positive association with homocysteine among test group (r=0.367, p ≤ 0.05), while the control group showed a weak negative association (r= -0.225, p ≤ 0.05). Equally, findings from this study corroborate earlier reports by Christodoulakos et al (2006) in which the plasma HCY levels dropped with increasing estrogen level. However, Osunkalu et al (2015) shows that the ovarian steroids did not show significant association with serum HCY levels in both infertile and fertile women.…”

Section: Discussionsupporting

confidence: 92%

Homocysteine levels of infertile females in Enugu, Enugu State, Nigeria

Ohiemim¹,

Okwuosa²,

Johnpaul³

2021

Direct Research Journal of Health and Pharmacology

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There are increasing indications that nutritional factors play a significant role in reproduction. Of crucial interest is the homocysteine pathway in which several nutrients are involved. Also, the essential role of homocysteine metabolism in fertility cannot be overemphasized. Therefore, the focus of this study is on Homocysteine levels of infertile female subjects in Enugu, Enugu State, Nigeria. Total numbers of 100 patients between the ages of 18 to 45 years were included, with 50 patients in case and 50 patients in control groups. Competitive Enzyme Linked immunosorbent assay (ELISA) was used for the estimation of homocysteine levels in the study subjects. The hormonal parameters analyzed and compared to the homocysteine levels include Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Prolactin (PRL), Progesterone (P4), and Estradiol (E4). The homocysteine levels (p ≤ 0.05) of infertile female patients revealed non-significant increased value (19.2±6.55µmol/ml) when compared to the control (14.0±5.31µmol/ml). FSH and homocysteine showed a significant negative association (r = -0.409, p ≤ 0.05) among the test group while no correlation was seen between FSH and homocysteine in the control group (r = 0.082, p ≤ 0.05). There was a positive association between homocysteine and LH in the test group (r =0.315, p ≤ 0.05) and a weak negative association between homocysteine and LH in the control group (r = -0.254. p ≤ 0.05). Progesterone (P4) did not show correlation with homocysteine among the test group (r = 0.016, p ≤ 0.05) while the control group showed a strong negative association (r = -0.679, p ≤ 0.05).

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Section: Discussionsupporting

confidence: 92%

Homocysteine levels of infertile females in Enugu, Enugu State, Nigeria

Ohiemim¹,

Okwuosa²,

Johnpaul³

2021

Direct Research Journal of Health and Pharmacology

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“…Proposed mechanisms relate to an increase in methionine synthase activity, transamination of methionine, or interfering with transsulfuration pathway resulting in irreversible catabolism of homocysteine to cysteine. 24 While the exact mechanism awaits further research, we have demonstrated in the current study that estradiol replacement counteracts the effect of dietary-induced increase in homocysteine level, a finding that is consistent with the following published animal and clinical observations: (1) estradiol-treated rats had lower total homocysteine concentrations ( P < .001) than those in nonestradiol-treated groups 12 ; (2) oral estrogen lowers plasma homocysteine levels in postmenopausal women, with the greatest effect in women in the higher quartile of plasma homocysteine levels at baseline 22,23,25,26 ; and (3) higher estrogen status is associated with a decreased mean serum total homocysteine concentration, independent of nutritional status and muscle mass, and that estrogen may explain the previously reported male–female difference in total homocysteine concentration. 27…”

Section: Discussionsupporting

confidence: 88%

Estrogen Replacement Attenuates Exaggerated Neointimal Hyperplasia Following Carotid Endarterectomy in Rats

Nyalala

Brown²,

Luo³

et al. 2011

Vasc Endovascular Surg

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“…However, we observed a statistically significant association between MTHFR Ala222Val polymorphism and androgenicity, BMI, and WHR. Insulin resistance bears an independent positive association with total testosterone and FAI (30), while it correlates positively with indices of obesity such as BMI and WHR (31). We propose the following hypothesis: genetic defects in Hcy metabolism may result in impaired Hcy catabolism which, at a cellular level, may lead to endothelial dysfunction thus causing insulin resistance.…”

Section: Discussionmentioning

confidence: 92%

Methylenetetrahydrofolate reductase C677T polymorphism is associated with central adiposity and increased androgenicity in healthy postmenopausal women

Lambrinoudaki

Kaparos²,

Papadimitriou³

et al. 2008

European Journal of Endocrinology

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Objective: To assess the association of genetic polymorphisms related to cardiovascular disease (CVD) risk with anthropometric parameters and indices of androgenicity in healthy postmenopausal women. Design: Cross-sectional study in a University Menopause Clinic. Methods: The following polymorphisms were assessed in 84 healthy postmenopausal women: glycoprotein IIIa Leu33Pro, apolipoprotein E2/E3/E4, methylenetetrahydrofolate reductase (MTHFR) Ala222Val, apolipoprotein B Arg3500Gln, paraoxonase 1 Gln192Arg, plasminogen activator inhibitor 1 4G/5G, cholesterol-7 a-hydroxylase A-204C, and cholesterol ester transfer protein (TaqIB) B1/B2. Hormonal assays included FSH, LH, 17-b-estradiol, testosterone, sex hormone-binding globulin (SHBG), DHEA sulfate, D-4-androstenedione (D4A), free androgen index (FAI), free estrogen index (FEI), and homocysteine (Hcy). The anthropometric components were body mass index (BMI) and waist-to-hip ratio (WHR). Results: MTHFR Ala222Val polymorphism was positively associated with testosterone, FAI, and FEI (PZ0.001, PZ0.0004, and PZ0.014 respectively) and negatively with SHBG (PZ0.047). Furthermore, women bearing this polymorphism had higher BMI and WHR compared with women with the wild-type variant (PZ0.027 and PZ0.044 respectively). Conclusions: MTHFR Ala222Val polymorphism is associated with increased androgenicity and elevated BMI and WHR in healthy postmenopausal women. The significance of this association with respect to the CVD risk of postmenopausal women remains to be elucidated in future studies. European Journal of Endocrinology 159 233-241

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Endogenous sex steroids and circulating homocysteine in healthy Greek postmenopausal women

Abstract: Endogenous estrogens and not androgens are related to serum homocysteine values in postmenopausal women. Whether this association has clinical implications remains to be clarified.

Cited by 8 publications

References 35 publications

Homocysteine levels of infertile females in Enugu, Enugu State, Nigeria

Homocysteine levels of infertile females in Enugu, Enugu State, Nigeria

Estrogen Replacement Attenuates Exaggerated Neointimal Hyperplasia Following Carotid Endarterectomy in Rats

Methylenetetrahydrofolate reductase C677T polymorphism is associated with central adiposity and increased androgenicity in healthy postmenopausal women

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