Endogenous SO2-dependent Smad3 redox modification controls vascular remodeling

Huang, Yaqian; Li, Zongmin; Zhang, Lulu; Tang, Huan; Zhang, Heng; Wang, Chu; Chen, Selena; Bu, Dingfang; Zhang, Zaifeng; Zhu, Zhigang; Yuan, Piaoliu; Li, Kun; Yu, Xiao‐Qi; Kong, Wei; Tang, Chaoshu; Jung, Young-Eun; Ferreira, Renan B.; Carroll, Kate S.; Du, Junbao; Yang, Jing; Jin, Hang

doi:10.1016/j.redox.2021.101898

Cited by 35 publications

(23 citation statements)

References 87 publications

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“…Endogenous SO 2 in the cardiovascular system, as an emerging gas transmitter, has important effects on blood pressure regulation and inhibition of vascular structural remodeling [ [35] , [36] , [37] , [38] ]. In the present study, we detected blood pressure by the tail-cuff method and implantable telemetry in the l -NAME-induced hypertension model mice and found that endogenous SO 2 levels were elevated, and blood pressure was elevated in these mice when the NO/NOS pathway was impaired.…”

Section: Discussionmentioning

confidence: 99%

Compensatory role of endogenous sulfur dioxide in nitric oxide deficiency-induced hypertension

Song

Zhu

et al. 2021

Redox Biology

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Section: Discussionmentioning

confidence: 99%

Compensatory role of endogenous sulfur dioxide in nitric oxide deficiency-induced hypertension

Song

Zhu

et al. 2021

Redox Biology

Self Cite

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“…The mechanism of SO2-dependent protection of vascular remodeling and hypertension has been linked to conversion of H2O2 to the potent oxidant, peroxymonosulfite (HOO-SO2 -) and concomitant S-sulfenylation of functional protein targets (Fig. 6c) 75 . Of these targets, Smad3 is essential to vascular physiology and S-sulfenylation of this transcription factor at cysteine 64 mediates interactions with other PTMs and has drawn major therapeutic interest.…”

Section: Size Of Redoxomementioning

confidence: 99%

Defining and refining the cysteine redoxome with sulfur chemical biology

Carroll

2022

Preprint

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Posttranslational changes in the redox state of cysteine residues can rapidly and reversibly alter protein function, modulating biological processes and drug pharmacology. Recent innovations in organosulfur chemistry, small-molecule tools, and computational methods for proteomic analysis have dramatically improved selectivity, cellular application, and site-specific quantitation of the cysteine redoxome. In this perspective, we start with a brief overview of cysteine sulfur chemistry and factors affecting thiol reactivity, followed by a critical discussion of similarities and differences between reactive and redox-sensitive cysteine residues. Next, we address mechanisms of post-translational cysteine oxidation and methods to quantify redoxome site-stoichiometry to prioritize follow-up study. Finally, we highlight recent chemoproteomic studies of the cysteine redoxome that offer new insights into the regulation of physiological processes and provide a framework for development of novel redox-based targeted therapeutic strategies.

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“…In order to maintain life activities, organisms undergo redox reactions all the time, in which multiple substances jointly maintain redox homeostasis [ 1 , 2 , 3 ]. Among them, sulfur dioxide (SO 2 ) is an important species for maintaining the redox balance in organisms and plays an important role in many bioactivities, including regulating vascular function [ 4 ] and protecting against acute lung injury [ 5 ]. It is also considered to be the fourth possible gas messenger molecule after nitric oxide [ 6 ], hydrogen sulfide [ 7 , 8 ] and carbon monoxide [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Rational Construction of a Mitochondria-Targeted Reversible Fluorescent Probe with Intramolecular FRET for Ratiometric Monitoring Sulfur Dioxide and Formaldehyde

Lyu¹,

Wang²,

Zhang³

2022

Biosensors

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Sulfur dioxide (SO2) and formaldehyde (FA) are important species that maintain redox homeostasis in life and are closely related to many physiological and pathological processes. Therefore, it is of great significance to realize the reversible monitoring of them at the intracellular level. Here, we synthesized a reversible ratiometric fluorescent probe through a reasonable design, which can sensitively monitor SO2 derivatives and FA, and the detection limit can reach 0.16 μM. The probe can specifically target mitochondria and successfully monitor the fluctuations of SO2 and FA in living cells. It also works well in the detection of SO2 and FA in zebrafish. This high-performance probe is expected to find broad in vitro and in vivo applications.

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Endogenous SO2-dependent Smad3 redox modification controls vascular remodeling

Cited by 35 publications

References 87 publications

Compensatory role of endogenous sulfur dioxide in nitric oxide deficiency-induced hypertension

Compensatory role of endogenous sulfur dioxide in nitric oxide deficiency-induced hypertension

Defining and refining the cysteine redoxome with sulfur chemical biology

Rational Construction of a Mitochondria-Targeted Reversible Fluorescent Probe with Intramolecular FRET for Ratiometric Monitoring Sulfur Dioxide and Formaldehyde

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