Endogenous Stimuli-responsive Nanocarriers for Drug Delivery

Abstract

Huachao Chen received her M.Sc. degree in chemistry from Shandong Normal University in 2011. After receiving her Ph.D. degree from the Nanjing University in 2015, she is now a lecturer at the China Pharmaceutical University. Her research interests include the multifunctional "stimulus-responsive" drug delivery system, antitumor plant cyclopeptides, and fluorescent imaging of bioactive substance.Danyang Liu received her B.S. degree in chemistry from Nanjing University in 2015. Then she joined Prof. Guo's group at Nanjing University to pursue her M.Sc. degree in bioinorganic chemistry. Her recent research focus on nanoparticle-based antitumor drug delivery. CL-151176Received AbstractDrug release in a spatially and temporally controlled manner is highly desired in the field of drug delivery. Endogenous stimuliresponsive nanocarriers provide significant advantages in maximizing the therapeutic efficacy and minimizing the side effects of loaded drugs. Biomarker-triggered release and site-specific delivery are the most commonly adopted strategies. In this review, the most recent advances in the field of endogenous stimuli-responsive drug delivery nanocarriers and their potential application in the treatment of various diseases are highlighted and discussed.

Polypeptide‐Based Conjugates as Therapeutics: Opportunities and Challenges

“…The human body represents a multitude of intrinsic microenvironments appropriate for the spatio‐temporal control of drug release. A multitude of systems have so far been described which have the ability to deliver a cargo or to activate the therapeutic effect, in response to an endogenous environmental factor (e.g., pH, redox potential, enzyme availability, or reactive oxygen species) or external stimuli (e.g., magnetic field, temperature, light) . Relevant examples of polypeptide conjugates described so far as drug delivery vehicles with inbuilt endogenously stimulated triggered release mechanisms are discussed within this section …”

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

“…Several smart drug delivery systems based on functionalized liposomes [6,7], micelles [8], mesoporous silica nanoparticles [9-12], carbon nanotubes [13], and inorganic nanoparticles [14] have been engineered. These systems allow to address the drug administration to the diseased tissue only [5,7], thus obtaining a reduction of the toxic effects of the drug along with an increase of the local drug concentration, and consequently an improvement of the therapeutic efficacy [15].…”

Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis

“…15 In order to deliver encapsulated drug to target tissues efficiently, efforts have been devoted to the development of intelligent delivery systems that respond to specific stimuli, such as pH level, temperature, and redox potential. [24][25][26][27][28] Among these are pH-responsive LPNPs, because the pH in inflammatory tissues (pH ~6.5), endosomes (pH ~5-6), and lysosomes (pH ~4-5) is significantly lower than that in blood circulation (pH ~7.4). 29,30 Poly(cyclohexane-1,4-diylacetone dimethylene ketal) (PCADK), a polyketal, is a promising material for constructing such drug carriers for inflammatory diseases and cancer, owing to its neutral degradation products and acid sensitivity.…”