Endogenous transplacental transmission of Neospora caninum in successive generations of congenitally infected goats

Oliveira, Ivam Moreira de; Mesquita, Lucas Emanuel dos Santos; Miranda, Débora Nunes Procópio; Gomes, Thaís Aurora; Vasconcelos, Beatriz Ketelin Sousa; Penha, Letícia Cristine; Silveira, Luisa Carolina Silva; Redondo, Anthony René Ramos; Costa, R. A.; Bruhn, Fábio Raphael Pascoti; Raymundo, Djeison Lutier; Wouters, Angélica Terezinha Barth; Wouters, Flademir; Varaschin, Mary Suzan

doi:10.1016/j.vetpar.2020.109191

Cited by 6 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As in cattle, endogenous transplacental transmission (due to reactivation of latent N. caninum infections during pregnancy) has been found to be highly successful in sheep (96.6% of gestations) [9] and in goats (71.4-100% vertical transmission rate) [42,43]. However, other studies in sheep described low vertical transmission rates (15-31%) without associated abortions [44,45].…”

Section: Discussionmentioning

confidence: 99%

Dynamics of Neospora caninum-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme

et al. 2021

View full text Add to dashboard Cite

Neospora caninum is an apicomplexan parasite that can cause abortions and perinatal mortality in sheep. Although ovine neosporosis has been described worldwide, there is a lack of information about the relationship between N. caninum serostatus and the reproductive performance. In this study, we described the infection dynamics in a dairy sheep flock with an abortion rate up to 25% and a N. caninum seroprevalence of 32%. Abortions were recorded in 36% and 9% of seropositive and seronegative sheep, respectively. Seropositive sheep were more likely to abort twice (OR = 4.44) or three or more times (OR = 10.13) than seronegative sheep. Endogenous transplacental transmission was the main route of transmission since 86% of seropositive sheep had seropositive offspring. Within dams that had any abortion, seropositive sheep were more likely than seronegative ones to have female descendants that aborted (OR = 8.12). The slight increase in seropositivity with the age, the low percentage of animals with postnatal seroconversion or with low avidity antibodies, and the seropositivity of one flock dog, indicated that horizontal transmission might have some relevance in this flock. A control programme based on selective culling of seropositive sheep and replacement with seronegative animals was effective in reducing the abortion rate to 7.2%.

show abstract

Section: Discussionmentioning

confidence: 99%

Dynamics of Neospora caninum-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Transmission of BVDV infection between small ruminants and cattle has been demonstrated, although usually it is from cattle to sheep or goats, and cattle can become infected with BDV (Braun et al, 2019). There are also reports of N. caninum abortions in goats in Brazil ( de Oliveira Junior et al, 2020), acting as intermediate hosts in the lifecycle of N. caninum. Therefore, goats' contributions to the seroprevalence of the two pathogens in our study should not be ignored.…”

Section: Bovine Viral Diarrhoea Virus and Neospora Caninum Co-infectionmentioning

confidence: 99%

Seroprevalence and risk factors of Neospora caninum and Bovine Viral Diarrhoea Virus in smallholder dairy cattle in Kenya

VanLeeuwen¹,

Muraya

Gitau

et al. 2021

EAJSTI

View full text Add to dashboard Cite

Little is known of the risk factors associated with occurrence of Neospora caninum and Bovine Viral Diarrhoea Virus (BVDV) infection in Kenya. This cross-sectional study hypothesized that there are significant biosecurity measures associated with N. caninum and BVDV infections on smallholder dairy farms in Kenya that could be adopted to reduce seroprevalence and impacts. From 158 randomly selected farms in Meru County, Kenya, 470 serum samples were collected from dairy cattle (over six months of age and unvaccinated for these two pathogens). Sera were analyzed for antibodies to N. caninum and antibodies and antigens to BVDV. Data on risk factors were obtained through face-to-face interviews with the farmers. Multivariable logistic regression models were used to identify significant risk factors associated with seropositivity for the pathogens. The apparent seroprevalence of N. caninum, BVDV antibody, BVDV antigen, and co-infection with N. caninum and BVDV antibody and/or antigen were 35.1%, 47.1%, 36.2% and 18.5%, respectively. Risk factors associated with N. caninum antibody included: introducing milking cows into the farm, lending of cattle between farms, farm dogs having access to bovine aborted fetuses, and dogs whelping in the farm compound, with an interaction between the last two variables. BVDV antigen was associated with cattle having contact with pigs, and an interaction between cattle age and whether farms introduced new calves onto farms, and cattle age and whether visiting dairy farmers have access to the cow shed. Cows had higher odds of having BVDV antibodies compared to heifers. Factors associated with co-infection included cow parity, direct contact between dairy cattle, dogs and goats, and introducing new milking cows into the farms. Antibody and antigen results may be partly a function of classical swine fever virus or border disease virus interactions. Farmer education on these biosecurity measures is recommended, along with introduction of BVDV vaccination.

show abstract

“…Reactivation of chronic N. caninum infection during pregnancy and endogenous transplacental transmission of the parasite to the offspring is known to be a common event in cattle, but the information on the efficiency of vertical transmission in small ruminants is still limited ( Lindsay and Dubey, 2020 ). Nevertheless, there is initial evidence that this way of transmission is also efficient in the ovine and caprine hosts ( de Oliveira Junior et al, 2020 ; Feitosa et al, 2021 ; González-Warleta et al, 2018 ; Pereira et al, 2021 ; Sánchez-Sánchez et al, 2021b ).…”

Section: Introductionmentioning

confidence: 99%

Toxoplasma gondii and Neospora caninum infections in sheep and goats in Switzerland: Seroprevalence and occurrence in aborted foetuses

Basso

Fabienne²,

Schares³

et al. 2022

Food and Waterborne Parasitology

View full text Add to dashboard Cite

Endogenous transplacental transmission of Neospora caninum in successive generations of congenitally infected goats

Cited by 6 publications

References 22 publications

Dynamics of Neospora caninum-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme

Dynamics of Neospora caninum-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme

Seroprevalence and risk factors of Neospora caninum and Bovine Viral Diarrhoea Virus in smallholder dairy cattle in Kenya

Toxoplasma gondii and Neospora caninum infections in sheep and goats in Switzerland: Seroprevalence and occurrence in aborted foetuses

Contact Info

Product

Resources

About