Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice prevent melanoma progression by increasing E-cadherin expression and inhibiting β-catenin signaling

Yin, Xuan; Yu, Xiaoyan; Zhu, Pan; Zhang, Yuanming; Zhang, Xiaohong; Wang, Feng; Zhang, Jin‐Jie; Wang, Yan; Xi, Yang; Wan, Jian‐Bo; Kang, Jing‐Xuan; Zou, Zhen; Bu, Shizhong

doi:10.3892/mmr.2016.5639

Cited by 12 publications

(9 citation statements)

References 51 publications

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“…Similarly, it was found that increasing the endogenous levels of n-3 PUFA, using n-3 fatty acid desaturase (fat-1) transgenic mice, was associated with a reduction in the growth rate of melanoma xenografts. This reduction in melanoma growth in fat-1 mice, compared with wild-type mice, was associated with an increased expression of E-cadherin and the reduced expression of its transcriptional repressors, Zeb-1 and Snail-1 (293). It also significantly repressed the EGFR/Akt/β-catenin signalling pathway and induced the formation of significant levels of anti-inflammatory n-3 PUFA-derived lipid mediators, such as resolvin D2 and E1, maresin 1 and 15-hydroxyeicosapentaenoic acid (293).…”

Section: The Perspectives Of Using Dietary Lipids For An Integrated Smentioning

confidence: 93%

Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment

Dumas

Brisson

Chevalier

et al. 2017

Seminars in Cancer Biology

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While tumours arise from acquired mutations in oncogenes or tumour-suppressor genes, it is clearly established that cancers are metabolic diseases characterized by metabolic alterations in tumour cells, and also non-tumour cells of the host organism resulting in tumour cachexia and patient weakness. In this review, we aimed at delineating details by which metabolic alterations in cancer cells, characterized by mitochondrial bioenergetics deregulations and the preference for aerobic glycolysis, are critical parameters controlling the aggressive progression of tumours. In particular, metabolic alteration in cancer cells are coupled to the modulation of intracellular and extracellular pH, epithelial-to-mesenchymal transition and associated increased invasiveness, autophagy, and the development of anticancer treatment resistance. Finally, based on mechanistic, pre-clinical and clinical studies, we proposed the adjuvant supplementation of dietary n-3 polyunsaturated fatty acids for a complementary holistic treatment of the cancer disease.

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Section: The Perspectives Of Using Dietary Lipids For An Integrated Smentioning

confidence: 93%

Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment

Dumas

Brisson

Chevalier

et al. 2017

Seminars in Cancer Biology

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show abstract

“…Autophagy inhibition suppressed apoptosis, and autophagy induction further enhanced apoptosis in response to DHA treatment (Jing et al, 2011). There is evidence that n-3 PUFA may inhibit the expression of EMT markers and reduce associated invasive properties in cancer cells (D'eliseo et al, 2016;Yin et al, 2016). Altogether, these effects could bring beneficial values to delay the appearance/diagnosis of a primary tumor and as such be of interest in primary prevention.…”

Section: Na V a As Targets For Nutritional Management Of Cancersmentioning

confidence: 99%

Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers

et al. 2021

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Voltage-gated sodium (Na V ) channels, initially characterized in excitable cells, have been shown to be aberrantly expressed in non-excitable cancer tissues and cells from epithelial origins such as in breast, lung, prostate, colon, and cervix, whereas they are not expressed in cognate non-cancer tissues. Their activity was demonstrated to promote aggressive and invasive potencies of cancer cells, both in vitro and in vivo, whereas their deregulated expression in cancer tissues has been associated with metastatic progression and cancer-related death. This review proposes Na V channels as pharmacological targets for anticancer treatments providing opportunities for repurposing existing Na V -inhibitors or developing new pharmacological and nutritional interventions.

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“…Dr. Jing X. Kang, who is director of the Harvard Center for Fatty Acid Research, noted that fatty acids, as well as vitamins and amino acids, are one of the most important nutrients in the human body. PUFAs ω-3 are one of two essential fatty acids that the human body cannot synthesize and that must enter the body with food, and the other -ω-6 fatty acids (Meester & Watson, 2008;Delpech et al, 2015;Liu et al, 2014;Luo et al, 2021;Wu et al, 2016;Yin et al, 2016).…”

Section: Literature Reviewmentioning

confidence: 99%

Effects of ω-3 fatty acids and ratio of ω-3/ω-6 for health promotion and disease prevention

Мухаметов¹,

YERBULEKOVA²,

AITKHOZHAYEVA³

et al. 2022

Food Sci. Technol

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Awareness of the role of essential fatty acids in human health and disease prevention has been increasing among the population over the past decades. It is known that the positive correlation of essential fatty acid content with a decrease in cardiovascular morbidity and mortality, infant development, brain and vision functioning, arthritis, hypertension, diabetes mellitus, and neurological/neuropsychiatric disorders. Rich sources of essential fatty acids are fish, fish oil, and some vegetable oils. In this paper, the average content of linoleic and α-linolenic acids in oils (g/100 g of fat) and their ratio is presented. In Kazakhstan, among vegetable oils, sunflower oil is the most commonly consumed, in which the ratio ω-6 to ω-3 on average is about 220:1, which exceeds all recommended norms. Based on the examination of literary data on this topic, the desk-based research approach was used in this paper. According to the results, statistical data on the number of diseases of the cardiovascular system and diabetes mellitus are confirmed by studies on the positive relationship between PUWC and the development of these diseases, which indicates the need to conduct more studies on the ratio of ω-6 to ω-3 in the diets. The objective of this research is to encourage scientists to increase their basic grasp of biochemistry in order to improve health and prevent fatty acid illness.

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Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice prevent melanoma progression by increasing E-cadherin expression and inhibiting β-catenin signaling

Cited by 12 publications

References 51 publications

Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment

Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment

Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers

Effects of ω-3 fatty acids and ratio of ω-3/ω-6 for health promotion and disease prevention

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