Endoluminal ultrasonography of the distal esophagus in systemic sclerosis

Miller, Larry S.; Liu, Ji‐Bin; Klenn, Philip J.; Holahan, Mary P.; Varga, John; Feld, Rick I.; Troshinsky, Matthew; Jimenez, Sergio A.; Castell, Donald O.; Goldberg, Barry B.

doi:10.1016/0016-5085(93)90007-y

Cited by 48 publications

(21 citation statements)

References 12 publications

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“…This might have been related to methodical problems of the histopathological examination [11][12][13]. Meanwhile, there are several observations demonstrating functional abnormalities [5,14] as an altered function of enteric neurons and a loss of smooth muscle with progressive fibrosis [2], and substantial evidence has accumulated that generalized GI dysmotility can be mainly attributed to abnormal collagen deposition and fibrosis during disease progression [15,16]. The thickening of the GI walls is in accordance with these observations.…”

Section: Discussionsupporting

confidence: 70%

“…We hypothesized that the functional abnormality of the GI tract would be associated with a characteristic qualitative or quantitative morphology of the GI wall resulting from fibrosis. With regard to the histological findings [5,[8][9][10], we expected a thickening of the GI wall in SSc patients compared with controls.…”

Section: Discussionmentioning

confidence: 94%

“…Endoscopic ultrasound (EUS) allows an accurate visualization of the GI wall [5,6]. We therefore proposed that accumulation of the extracellular matrix could be detected by the EUS in SSc patients suffering from GI involvement.…”

Section: Introductionmentioning

confidence: 99%

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Gastrointestinal manifestation of systemic sclerosis—thickening of the upper gastrointestinal wall detected by endoscopic ultrasound is a valid sign

et al. 2009

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Objective. Gastrointestinal (GI) tract involvement has been observed in the majority of patients with SSc. This has been attributed to an accumulation of extracellular matrix within the GI walls. We visualized the walls of the oesophagus, stomach and duodenum with its layers and measured the thickness in SSc patients and control patients utilizing endoscopic ultrasound (EUS).Methods. Twenty-five SSc patients and 25 controls were evaluated. In addition to analysis of clinical symptoms, endoscopy and EUS (20-MHz miniprobe) were performed. The thickness of the complete wall was measured, and the mucosa, submucosa and muscularis were evaluated separately. Conclusions. The EUS revealed a significant thickening of the walls of the upper GI tract in SSc patients. Predominantly, the submucosa and muscularis are enlarged. These results strengthen the hypothesis that increased matrix deposition is an important aspect in the pathogenesis of GI involvement in SSc.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 94%

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Gastrointestinal manifestation of systemic sclerosis—thickening of the upper gastrointestinal wall detected by endoscopic ultrasound is a valid sign

et al. 2009

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“…For example, patients with scleroderma have a severe defect in peristalsis due to replacement of esophageal muscle with fibrous connective tissue (20), whereas patients with moderate esophagitis may have ineffective esophageal motility that reverses after appropriate cholinergic stimulation with edrophonium (6).…”

mentioning

confidence: 99%

Effect of repeated cycles of acute esophagitis and healing on esophageal peristalsis, tone, and length

Zhang

Geboes

Depoortere

et al. 2005

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…The application of this technology to esophageal imaging has been described in esophageal varices and in systemic sclerosis. 6,7 In this study we report our early experience using these transducers to image esophageal carcinoma. In particular, we assess the feasibility of the technique and its usefulness in the staging of these tumors.…”

mentioning

confidence: 99%

High resolution endoluminal ultrasonography in the staging of esophageal carcinoma.

McLoughlin

Cooperberg²,

Mathieson³

et al. 1995

Journal of Ultrasound in Medicine

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Small catheters containing 20 MHz transducers have recently become available for high resolution endoluminal ultrasound. We report our early use of this technique to image and stage esophageal carcinoma. Fifteen patients undergoing high resolution endoluminal ultrasonography for suspected esophageal carcinoma were studied. Twelve of these patients also underwent computed tomography and pathologic correlation was available in seven. Satisfactory esophageal examination was possible in 14 of 15 patients. Of those with pathologic correlation, the depth of tumor invasion was correctly staged by high resolution endoluminal ultrasonography in six of seven patients and by computed tomography in only three of seven patients. Lymph node assessment correlated poorly with pathologic findings for both high resolution endoluminal ultrasound and computed tomography. With the increasing use of preoperative radiation therapy, we believe these early results predict a potential role for high resolution endoluminal ultrasonography in the staging of esophageal carcinoma.

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Endoluminal ultrasonography of the distal esophagus in systemic sclerosis

Cited by 48 publications

References 12 publications

Gastrointestinal manifestation of systemic sclerosis—thickening of the upper gastrointestinal wall detected by endoscopic ultrasound is a valid sign

Gastrointestinal manifestation of systemic sclerosis—thickening of the upper gastrointestinal wall detected by endoscopic ultrasound is a valid sign

Effect of repeated cycles of acute esophagitis and healing on esophageal peristalsis, tone, and length

High resolution endoluminal ultrasonography in the staging of esophageal carcinoma.

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