Endolymphatic space is age-dependent

Dieterich, Marianne; Hergenroeder, Tatjana; Boegle, Rainer; Gerb, J.; Kierig, E.; Stöcklein, Sophia; Kirsch, V.

doi:10.1007/s00415-022-11400-8

Cited by 4 publications

(2 citation statements)

References 64 publications

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“…In the same regression model, patient age did not significantly affect the presence of ELH. Dieterich et al (18) recently reported that the size of the endolymphatic space on MRI correlated positively with age (21–75 yr) in 32 healthy subjects with normal vestibular function. Conversely, Inui et al (19) reported that the size of the endolymphatic space in 24 healthy control subjects was smaller in older (>60 yr) individuals than in younger (<60 yr) individuals.…”

Section: Discussionmentioning

confidence: 99%

Endolymphatic Hydrops on Magnetic Resonance Imaging May Be an Independent Finding on Aging in Neurotologic Patients

Maeda¹,

Kojima

Takao

et al. 2023

Otol Neurotol

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Objective To clarify whether age impacts the development of endolymphatic hydrops (ELH) in neurotologic patients. Documentation of ELH in living patients on magnetic resonance imaging (MRI) allows analysis of patient age and formation of ELH, which is impossible by means of postmortem temporal bone pathology. Study Design Retrospective case review. Setting Tertiary referral center. Patients Fifty patients (100 ears) with top 3 diagnoses of definite Menière's disease, delayed ELH, or probable Menière's disease. Interventions Endolymph MRI after intravenous gadolinium injection and pure-tone audiometry. Main Outcome Measures Cochlear and vestibular ELH confirmed by MRI. Results The prevalences of ears showing both cochlear and vestibular ELH were similar among age groups <30 years (30%), 30–59 years (25.9%), and ≥60 years (34.4%; p > 0.05; χ 2 test). Using logistic regression modeling, mean hearing level at the six frequencies was positively associated with a higher risk of cochlear ELH (odds ratio, 1.3; 95% confidence interval, 1.1–1.5 per 10-dB increment). In the same regression model, age did not impact the outcome of cochlear ELH (odds ratio, 1.0; 95%confidence interval, 0.7–1.4 per 10-year increment). Age did not differ among ears with no ELH (mean ± standard deviation age, 48.6 ± 14.4 yr), ears with only cochlear ELH (59.3 ± 10.7 yr), ears with only vestibular ELH (50.4 ± 16.9 yr), or ears with both cochlear and vestibular ELH (51.5 ± 18.4 yr; p > 0.05, analysis of variance). Conclusion Chronological age was not associated with the formation of ELH. Aging per se may not be associated with the development of ELH in neurotologic patients.

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Section: Discussionmentioning

confidence: 99%

Endolymphatic Hydrops on Magnetic Resonance Imaging May Be an Independent Finding on Aging in Neurotologic Patients

Maeda¹,

Kojima

Takao

et al. 2023

Otol Neurotol

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“…Распространенность развития двусторонней формы заболевания увеличивается с возрастом [17]. Общая частота пациентов с двусторонней формой БМ -24%, из которых у 11% двусторонняя форма заболевания устанавливалась уже при первых признаках БМ, а у 14% заболевание прогрессировало от односторонней к двусторонней форме [18]. По некоторым данным, односторонняя форма БМ прогрессировала до двусторонней формы у 35% пациентов в течение 10 лет и у 47% в течение 20 лет [19].…”

Section: эпидемиологияunclassified

Meniere’s Disease: The Current State of the Problem

Марьенко¹,

Поддубный²

2023

Неврология И Нейрохирургия. Восточная Европа

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Болезнь Меньера (БМ) – многофакторное заболевание внутреннего уха, характеризующееся головокружением, шумом в ушах и нейросенсорной потерей слуха. Заболевание не имеет определенной этиологической причины. Развитие БМ зависит от целого ряда факторов, которые способны приводить к эндолимфатической водянке. Основным морфологическим признаком БМ является эндолимфатический гидропс – увеличение объема эндолимфы, заполняющей перепончатый лабиринт внутреннего уха, и растяжение Рейснеровой мембраны. Различают 3 основных варианта течения заболевания. Рост количества случаев БМ у лиц молодого возраста, а также отсутствие скрининга у лиц с повышенным риском (люди в возрастной категории от 20 до 50 лет со сниженным слухом на 1 или оба уха, с отягощенным семейным анамнезом по данному заболеванию, с травмами головы и/или уха, аутоиммунными заболеваниями) делает актуальной проблему разработки методов ранней диагностики и комплексного лечения БМ в Республике Беларусь. Meniere’s disease (MD) is a multifactorial disease of the inner ear characterized by dizziness, tinnitus and sensorineural hearing loss. The disease has no definite etiological cause. The development of MD depends on a number of factors that can lead to the development of endolymphatic dropsy. The main morphological feature of MD is endolymphatic hydrops: an increase in the volume of the endolymph filling the membranous labyrinth of the inner ear, and stretching of the Reissner’s membrane. There are three main variants of the disease course. The increasing number of MD cases in young people, as well as the lack of screening in high-risk populations (individuals aged 20 to 50 years with impaired hearing in one or both ears, having family history aggravated with this disease, with head and/ or ear injuries, or with autoimmune diseases) make the issue of developing methods for early diagnosis and comprehensive treatment of MD in the Republic of Belarus relevant.

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Correlation between the etiology of severe hearing loss and endolymphatic hydrops

Park,

Han,

Lee

et al. 2024

Eur Arch Otorhinolaryngol

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Purpose This study aimed to investigate correlation between the presence of endolymphatic hydrops(EH) and factors such as causes of hearing loss, patient age, duration of deafness, and results of vestibular function tests. Methods We retrospectively reviewed medical charts of 128 ears of cochlear implantees who were not considered relevant to Meniere’s disease. Results When comparing group with genetic variants of GJB2, SLC26A4, LMX1A and other genetic mutation group, the proportion of vestibular EH and cochlear EH found in group with genetic variants of GJB2, SLC26A4, LMX1A was significantly higher than group with other genetic etiology (p < 0.01) or the group with all the other causes of hearing loss (p < 0.01). The rate of vestibular and cochlear EH detection was higher in younger patients (41.5% and 35.4%) than in older patients (25.4% and 20.6%). A higher ratio of vestibular and cochlear EH was observed in patients with a longer duration of deafness (37.5% and 31.3%) than those with a shorter duration of deafness (29.7% and 25.0%). The group with vestibular EH showed a higher incidence of abnormal findings in the caloric test (42.9%) than the group without vestibular EH (28.2%). Conclusion Patients with genetic variants of GJB2, SLC26A4, LMX1A, younger patients, those with longer deaf durations showed a higher prevalence of vestibular and cochlear EH, implying EH appears to be formed as a developmental disorder in association with a certain set of genetic variants, rather than a phenotypic marker as a result of severe to profound hearing loss.

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Endolymphatic space is age-dependent

Cited by 4 publications

References 64 publications

Endolymphatic Hydrops on Magnetic Resonance Imaging May Be an Independent Finding on Aging in Neurotologic Patients

Endolymphatic Hydrops on Magnetic Resonance Imaging May Be an Independent Finding on Aging in Neurotologic Patients

Meniere’s Disease: The Current State of the Problem

Correlation between the etiology of severe hearing loss and endolymphatic hydrops

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