Endometrial adenocarcinoma metastatic to the right ventricle: a case report and review of the literature

Castillo-Sang, Mario; Slam, Kristine; Gociman, Barbu; Durham, Samuel J.; Booth, Robert

doi:10.1016/j.carpath.2007.12.007

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…The three most common malignant neoplasms appear to be carcinoma of the lung, esophageal carcinoma, and lymphoma [1]. A literature search for particular metastatic spread of endometrial adenocarcinoma to the right ventricle revealed only four cases [2][3][4][5]. Right heart catheterization and biopsy, if necessary, should be performed under ultrasound guidance, for fatal adverse hemodynamic consequences have been reported [6].…”

Section: Discussionmentioning

confidence: 99%

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Solitary right ventricular metastasis of endometrial adenocarcinoma

Horlbeck

Werner

Hammerstingl

et al. 2015

Journal of Cardiology Cases

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A 64-year-old woman presented with swelling of her left leg and mild dyspnea [New York Heart Association (NYHA) class II]. Her medical history consisted of a poorly differentiated adenosquamous carcinoma of the uterus (FIGO 1B, G3). To date, the patient was classified disease-free 5 months after curative surgery (hysterectomy and bilateral salpingo-oophorectomy) with postoperative radiotherapy and denied any B symptoms.Ultrasound revealed old iliacal deep venous thrombosis with only mild elevation of D-dimer (1.2 mg/l). Subsequent computed tomography detected diffuse pulmonary embolism as a probable cause of dyspnea and, surprisingly, a large mass in the right ventricle (RV). Echocardiography showed a nearly complete obstruction of the dilated RV with the beginning of obstruction of the inflow tract, moderate tricuspid regurgitation, developing hepatic congestion, and floating parts of the huge intracardiac mass (Figs. 1 and 2). Echocardiographic measured RV pressure was 30 mmHg, basal RV and areas without direct tumor contact

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Section: Discussionmentioning

confidence: 99%

“…The intracardiac mass may initially be asymptomatic but subsequent obstruction of the RV outflow tract can swiftly accelerate the course of the disease resulting in poor prognosis [2,4,6].…”

Section: Discussionmentioning

confidence: 99%

Solitary right ventricular metastasis of endometrial adenocarcinoma

Horlbeck

Werner

Hammerstingl

et al. 2015

Journal of Cardiology Cases

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“…A report by Greenwald et al [3] showed 6 of 1,100 gynecological cancer cases to have metastasis to the heart, but none was endometrial in origin. We were able to find several reported cases of cardiac metastasis from endometrial cancer in the past 30 years [4][5][6][7][8], two of which were from endometrial sarcoma [4,8], which are less rare than the cardiac metastasis from endometrial adenocarcinoma, like in our case [9]. As with our case, the cases we found describe metastasis in the right ventricle, two of which also involved right ventricular malignancy, causing obstruction in the right ventricular outflow tract [4,5].…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of Cardiac Metastasis from Endometrial Cancer by F-18 FDG-PET/CT

Liu

Khan

Behr

et al. 2014

Nucl Med Mol Imaging

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We report a case of a 59-year-old woman with right ventricular metastasis of undifferentiated endometrial cancer. Cardiac metastasis from endometrial cancer is a very rare finding. The case demonstrates that undifferentiated endometrial cancer is capable of metastasizing, presumably through a hematogenous route, to unexpected distant organs. These unexpected sites should not be undermined in the restaging and surveillance of these patients.

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