Endometrial and vaginal microbiomes influence assisted reproductive technology outcomes

Miyagi, Masaya; Mekaru, Keiko; Tanaka, Shino; Arai, Wataru; Ashikawa, Kyota; Sakuraba, Yoshiyuki; Nakamura, Rie; Oishi, Sugiko; Akamine, Kozue; Aoki, Yoichi

doi:10.5935/1518-0557.20220040

Cited by 3 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, the presence of lactobacilli that produce H 2 O 2 increases the chance of birth, while the presence of bacteria of the genus Streptococcus reduces it [87,88]. In contrast, microbial culture of vaginal and endometrial specimens by women undergoing IVF/ICSI (Intra-Cytoplasmic Sperm Injection) showed that the presence of germs did not benefit a successful pregnancy [96,97].…”

Section: The Microbiota Of Female and Male Reproductive Systemmentioning

confidence: 99%

An Overview of the Microbiota of the Human Urinary Tract in Health and Disease: Current Issues and Perspectives

Colella

Topi

Palmirotta

et al. 2023

Life

View full text Add to dashboard Cite

This article is intended to deepen our knowledge to date regarding the functions of the resident microbiota/microbiome in the urinary system for human health and disease. First, we sought to report the general characteristics (composition and stability) of the normal urinary system microbiota in the different anatomical sites in relation to some factors such as the effect of age, gender and diet, analyzing in detail the functions and the composition of the microbiota in the light of current knowledge. Several pieces of evidence suggest the importance of preserving the micro-ecosystem of the urinary system, and in some cases their relationship with diseases is important for maintaining human health is well understood. The female and male reproductive microbiota have mainly been studied over the past decade. In the past, the arrest was thought to have taken place in a sterile environment. Microorganisms of the microbiota form biofilms, three-dimensional structures, that differ in the reproductive organs and interact with both gametes and the embryo as well as with maternal tissues. These biofilms from the reproductive system also interact with others, such as that of the gastrointestinal tract. Reduction in its diversity intestinal microbiota can disrupt estrogen metabolism and affect the reproductive microbiota. It is therefore understood that its quantitative and qualitative identification is important for microbiota, but also the study of the structures formed by the microorganisms. A dysbiosis with local or systemic causes can lead to serious diseases. The role of probiotics in maintaining microbial population harmony (eubiosis) and preventing certain pathologies of the urinary and reproductive system was also investigated. A negative variation in the qualitative and quantitative composition of certain strains of microorganisms (dysbiosis) due to local or systemic causes can even lead to serious diseases. The role of probiotics in maintaining the healthy balance of microorganism populations (eubiosis), and thus in the prevention of certain pathologies of the urinary and reproductive system, has also been studied.

show abstract

Section: The Microbiota Of Female and Male Reproductive Systemmentioning

confidence: 99%

An Overview of the Microbiota of the Human Urinary Tract in Health and Disease: Current Issues and Perspectives

Colella

Topi

Palmirotta

et al. 2023

Life

View full text Add to dashboard Cite

show abstract

“…A higher diversity in the microbial population of the vagina was detected in women with RIF when compared to control women [ 32 ]. An abundance of genera and species related to bacterial vaginosis such as Gardnrella , Atopobium , Prevotella , Megasphaera , Burkholderia , and Sneathia , and reduced numbers of Lactobacilli were reported [ 67 ] in the women affected by RIF in contrast to controls by several independent studies [ 55 , 68 , 69 , 70 , 71 , 72 , 73 ]. As far as the Lactobacillus species are concerned, a relative predominance of Lactobacillus helveticus and not of L. iners , L. crispatus , L.jensii , and L. gasseri was shown to exist in the women with RIF [ 68 ].…”

Section: Microbiota and Rifmentioning

confidence: 99%

“…Another bacterial genus linked to RIF when present in the endometrium is that of Bifidobacterium [ 79 ]. Another set of studies has shown a drastic decrease in Lactobacilli and an abundance of Dialister , Prevotella , Gardnerella , and Anaeroccus in women with chronic endometritis [ 28 , 67 ]. The disruption of the healthy uterine microbiome is thought to result in chronic endometritis [ 77 ] and triggers a pro-inflammatory response that renders the endometrium unfavorable for implantation [ 22 , 32 , 80 ].…”

Section: Microbiota and Rifmentioning

confidence: 99%

Understanding the Role of Female Genital Tract Microbiome in Recurrent Implantation Failure

Lafioniatis,

Samara,

Makaritsis

et al. 2024

JCM

View full text Add to dashboard Cite

The realization of the role of the microbiome of the female reproductive tract in health and disease has opened numerous possibilities for the scientific examination of the intertwining role between the human host and its microbiota. The imbalance in the composition of the microbial communities of the vagina and uterus is now recognized as a risk factor for many complications in pregnancy and according to the data from numerous studies, it is possible for this imbalance to play a crucial role in creating a hostile endometrial environment, and therefore, contributing to the etiology of recurrent implantation failure. Nevertheless, our current understanding of these complicated biological phenomena is far from complete, and in the future, there needs to be a systematic and thorough investigation of the diagnosis and therapy of this condition. This will enable scientists who engage in the field of assisted reproduction technologies to accurately identify and cure women in whom dysbiosis hinders the achievement of a healthy pregnancy.

show abstract

“…The vaginal microbiome is known to play a crucial role in vaginal health. Most research into reproductive outcome has shown that the dominant presence of Lactobacillus species within the female reproductive tract is associated with reproductive success, while adverse reproductive outcome seems to be associated with a non-dominant Lactobacillus environment and a generalized higher microbial diversity and richness [ 13 , 14 , 15 , 16 ]. Moreover, depletion of vaginal Lactobacillus spp.…”

Section: Introductionmentioning

confidence: 99%

Clinical Relevance of Vaginal and Endometrial Microbiome Investigation in Women with Repeated Implantation Failure and Recurrent Pregnancy Loss

Gao,

Louwers,

Laven

et al. 2024

IJMS

View full text Add to dashboard Cite

Recent studies have investigated if and how the vaginal and endometrial microbiome might affect endometrial receptivity and reproductive health. Although there is no consensus on the existence of a core uterine microbiome yet, evidence shows that the dominance of Lactobacillus spp. in the female reproductive tract is generally associated with eubiosis and improved chances of successful implantation and an ongoing pregnancy. Conversely, vaginal and endometrial dysbiosis can cause local inflammation and an increase of pro-inflammatory cytokines, compromising the integrity and receptivity of the endometrial mucosa and potentially hampering successful embryonic implantation. This review provides a critical appraisal of the influence of the vaginal and endometrial microbiome as parts of the female reproductive tract on fertility outcomes, focusing on repeated implantation failure (RIF) and recurrent pregnancy loss (RPL). It seems that RIF as well as RPL are both associated with an increase in microbiome diversity and a loss of Lactobacillus dominance in the lower female reproductive system.

show abstract

Endometrial and vaginal microbiomes influence assisted reproductive technology outcomes

Abstract: This study was presented at the 65 th Annual Meeting of the Japan Society for Reproductive Medicine.

Cited by 3 publications

References 47 publications

An Overview of the Microbiota of the Human Urinary Tract in Health and Disease: Current Issues and Perspectives

An Overview of the Microbiota of the Human Urinary Tract in Health and Disease: Current Issues and Perspectives

Understanding the Role of Female Genital Tract Microbiome in Recurrent Implantation Failure

Clinical Relevance of Vaginal and Endometrial Microbiome Investigation in Women with Repeated Implantation Failure and Recurrent Pregnancy Loss

Contact Info

Product

Resources

About