Endometrial CD16<sup>+</sup>and CD16<sup>−</sup>NK Cell Count in Fertility and Unexplained Infertility

Junovich, G.; Azpiroz, A.; Incera, Eugenia; Ferrer, Christian; Pasqualini, A.; Gutiérrez, Gabriela

doi:10.1111/aji.12132

Cited by 29 publications

(29 citation statements)

References 29 publications

(43 reference statements)

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“…In addition, Fukui et al 15 observed an increase of the percentage of CD16 + CD56 dim cells and decrease in the percentage of CD16 − CD56 bright cells in women with infertility who miscarried after IVF cycles compared with women who delivered. Most recently, Junovich et al 18 reported an increased number of CD16 + endometrial NK cells in patients with unexplained infertility that correlated with a decrease in endometrial IL-6 and VEGF levels. Therefore, it can be hypothesized that an increase in “activated” CD16 + uNK cells may create an unfavorable environment for implantation.…”

Section: Discussionmentioning

confidence: 99%

“…For example, while some previous case-control studies report a higher concentration of uNK cells in women with uRPL compared to fertile women 9,10,11,12,13 , other studies did not find this association 5,14 . Similarly, evidence exists for both an association and lack of association between uNK cell number/function and infertility 15,16,17,18 . Only few studies have examined changes of uNK cell numbers in endometriosis, demonstrating a lower percentage of CD56 + NK cells and a defect in NK activity in the eutopic endometrium of women with endometriosis 19, 20, 21, 22 .…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Uterine NK Cells in Women with Infertility or Recurrent Pregnancy Loss and Associated Endometriosis

Giuliani

Parkin

Lessey

et al. 2014

American J Rep Immunol

142

106

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Problem Uterine natural killer cells (uNK) have been thought to play a key role in endometriosis and infertility. We investigated the expression of CD56, CD16 and NKp46 in endometrial tissues from 61 women with unexplained recurrent pregnancy loss (uRPL) or infertility (UI), and correlated this with the presence or absence of endometriosis. The results from the patients with sub-fertility were compared to those from 10 fertile patients. Method of study Mid-secretory phase endometrial biopsies were obtained and the endometrial expression of CD56, CD16 or NKp46 was identified by immunohistochemistry and quantified (ImageJ Software). Results The percentage of CD16+ cells was higher in women with uRPL (7.9±3.2) and UI (9.0±5.5), even when these conditions were associated with endometriosis (8.9±5.3), compared to fertile patients (5.6±2.4, p<0.05). Likewise, the ratio of NKp46+:CD56+ cells was higher in women with uRPL (0.28±0.25) and UI (0.21±0.2), even when these conditions were associated with endometriosis (0.19±0.14), compared to fertile patients (0.1±0.1, p<0.05). No differences were observed when comparing CD56. Conclusions Women, with or without endometriosis, who have larger populations of cytotoxic CD16+ uNK cells and/or higher populations of NKp46+CD56+ cells may be at greater risk for infertility disorders resulting from an inflammtory environment occuring during implantation or later during decidualization.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of Uterine NK Cells in Women with Infertility or Recurrent Pregnancy Loss and Associated Endometriosis

Giuliani

Parkin

Lessey

et al. 2014

American J Rep Immunol

142

106

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“…Special focus has been on IL6, a key mediator of immune and acute phase responses, as several studies indicate that dysregulation of IL-6 may disturb implantation and be harmful to pregnancy [32, 33]. IL-6 is a key cytokine that blocks the development of regulatory T (Treg) cells and induces the differentiation of Th17 cells.…”

Section: Methodsmentioning

confidence: 99%

Female Asthma Has a Negative Effect on Fertility: What Is the Connection?

Gade

Thomsen

Lindenberg³

et al. 2014

ISRN Allergy

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Reproductive changes such as impaired fertility and adverse pregnancy outcomes have been related to female asthma. We recently found that time to pregnancy is prolonged in asthmatic females especially in women with moderate to severe asthma and in those above 30 years of age. Despite their reproductive difficulties the asthmatics ultimately conceived just as many biological children as healthy throughout their reproductive lives. This knowledge therefore raises questions about how asthma affects fertility pathophysiologically. The purpose of this review is to describe the existing knowledge in this field and suggest hypotheses of causal relationships, which may form the basis for future studies in this field. The aim is, in particular, in the literature to examine whether there is any evidence to suggest that the systemic inflammation that characterizes asthma, can affect fertility. The issue is potentially clinically important for asthmatic, infertile individuals and society because treatment of the general systemic inflammation associated with the asthmatic disease combined with hormone stimulation might be the optimal target for an effective infertility therapy, possibly decreasing the need for in vitro fertilization.

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“…However, they considered that the value of measuring NK cell activity or number as a prognostic indicator of pregnancy success was still undetermined. On the other hand, various reports have documented the usefulness of measuring pre-pregnancy peripheral blood or endometrial NK cells as an indicator of reproductive success [6][7][8][9][10][11][12][13][14][15][16][17][18]. NK cell cytotoxicity at the time of embryo transfer is significantly higher in women who miscarry [9], and the count of pre-pregnancy peripheral CD56 ?…”

Section: Introductionmentioning

confidence: 99%

“…/CD56 dim NK cells is also significantly higher in women who miscarry [9] or those with RPL [18]. In women with reproductive failure, pre-pregnancy cytokine production by NK cells shows a shift from type 2 to type 1 [11], and expression of NK cell activating and inhibitory receptors also alters [10,[12][13][14]17].…”

Section: Introductionmentioning

confidence: 99%

NK cell abnormality and its treatment in women with reproductive failures such as recurrent pregnancy loss, implantation failures, preeclampsia, and pelvic endometriosis

Fukui

Kamoi

Funamizu

et al. 2015

Reprod Medicine & Biology

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The regulation of uterine and peripheral blood natural killer (NK) cells has been associated with problems related to reproductive immunology such as recurrent pregnancy loss (RPL), implantation failure or preeclampsia. NKp46, one of the natural cytotoxicity receptors (NCRs), is a unique marker that functions in NK cell cytotoxicity and cytokine production. Expression of NKp46 on NK cells is lower in women with recurrent pregnancy loss and pregnancy-induced hypertension. Moreover, expression of NKp46 on peritoneal fluid NK cells is lower in women with pelvic endometriosis. Therefore, evaluation of NKp46 on peripheral blood NK cells may provide a means of screening for reproductive abnormalities. Recently, a new type of NK cell, the NK22 cell, has been reported. This cell may be a regulator not only of the mucosal barrier but also of reproduction. For women with RPL showing abnormal uterine and/or peripheral blood NK cells, both intravenous immunoglobulin treatment and intralipid treatment have been reported. The effects of these treatments are still controversial, and further studies are needed in order to clarify their true impact. The present review examines variations in the expression of NCRs on NK cells, the participation of NK22 cells in reproduction, and the possible use of intravenous immunoglobulin or intralipid treatment for women with recurrent pregnancy loss and NK cell abnormality.

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Endometrial CD16⁺and CD16⁻NK Cell Count in Fertility and Unexplained Infertility

Abstract: Increased CD16(+ ) NK cells were associated with IL-6 and VEGF deficiency in a high proportion of UI-IF patients. Testing for these immunomarkers could be a potential tool in infertility diagnosis.

Cited by 29 publications

References 29 publications

Characterization of Uterine NK Cells in Women with Infertility or Recurrent Pregnancy Loss and Associated Endometriosis

Characterization of Uterine NK Cells in Women with Infertility or Recurrent Pregnancy Loss and Associated Endometriosis

Female Asthma Has a Negative Effect on Fertility: What Is the Connection?

NK cell abnormality and its treatment in women with reproductive failures such as recurrent pregnancy loss, implantation failures, preeclampsia, and pelvic endometriosis

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Endometrial CD16+and CD16−NK Cell Count in Fertility and Unexplained Infertility

Abstract: Increased CD16(+ ) NK cells were associated with IL-6 and VEGF deficiency in a high proportion of UI-IF patients. Testing for these immunomarkers could be a potential tool in infertility diagnosis.

Cited by 29 publications

References 29 publications

Characterization of Uterine NK Cells in Women with Infertility or Recurrent Pregnancy Loss and Associated Endometriosis

Characterization of Uterine NK Cells in Women with Infertility or Recurrent Pregnancy Loss and Associated Endometriosis

Female Asthma Has a Negative Effect on Fertility: What Is the Connection?

NK cell abnormality and its treatment in women with reproductive failures such as recurrent pregnancy loss, implantation failures, preeclampsia, and pelvic endometriosis

Contact Info

Product

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Endometrial CD16⁺and CD16⁻NK Cell Count in Fertility and Unexplained Infertility