Endometrial Cyst, Dermoid Cyst and Mucinous Cystadenoma Sonographically Evidenced in the Same Ovary

Hata, Kohkichi; Hata, Toshiyuki; Kitao, Manabu; Aoki, Showa; Matsunaga, Isao

doi:10.1159/000293646

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…Our literature search retrieved several reports of mucinous cystadenoma occurring synchronously with other ovarian tumors such as endometrial cyst and dermoid cyst [4], anaplastic carcinoma [18], clear-cell carcinoma [19], choriocarcinoma [20], granulosa cell tumor, and mature teratoma [21]. Morris et al [22] suggested that some mucinous tumors may derive from germ cells, for instance, in mature teratoma; and our report supports this hypothesis.…”

Section: Discussionsupporting

confidence: 82%

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Mucinous cystadenoma arising 3 years after ovarian-sparing surgery for mature teratoma in a child

Parmentier

Vaz

Chabaud-Williamson

et al. 2010

Journal of Pediatric Surgery

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Section: Discussionsupporting

confidence: 82%

“…Mature or immature recurrence may occur during follow-up [1][2][3]. Synchronous ovarian teratoma with mucinous cystadenoma has been reported in a few patients [4][5][6][7][8][9]. Mucinous cystadenoma is extremely rare during childhood [10].…”

mentioning

confidence: 99%

Mucinous cystadenoma arising 3 years after ovarian-sparing surgery for mature teratoma in a child

Parmentier

Vaz

Chabaud-Williamson

et al. 2010

Journal of Pediatric Surgery

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“…Mucinous neoplasms occur rarely in association with cystic teratoma, Sertoli‐Leydig cell tumor, granulosa cell tumor and carcinoid tumor 20 . Only a few cases of dermoid cyst and benign cystadenoma in the same ovary have been reported 21,22 . We did not come across any cases of dermoid cyst and yolk sac tumor in the same ovary in the literature.…”

Section: Discussionmentioning

confidence: 94%

Germ cell tumors of the ovary: A clinicopathologic study of 121 cases from Nepal

Sah¹,

Uprety

Rani³

2004

J of Obstet and Gynaecol

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Ovarian Mucinous Tumors Associated With Mature Cystic Teratomas

Vang

Gown²,

Zhao³

et al. 2007

American Journal of Surgical Pathology

167

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Most primary ovarian mucinous tumors are of surface epithelial-stromal origin and exhibit diffuse expression of cytokeratin 7 (CK7) combined with variable expression of cytokeratin 20 (CK20); this immunoprofile distinguishes them from most lower gastrointestinal tract tumors secondarily involving the ovaries. The uncommon ovarian mucinous tumors of germ cell (teratomatous) origin have not been extensively evaluated to determine the utility of these markers and other markers of intestinal differentiation for distinguishing these tumors from metastatic gastrointestinal tract mucinous tumors. Immunohistochemical expression of CK7, CK20, CDX2, and villin was assessed in 44 ovarian mucinous tumors associated with a mature cystic teratoma. All cases lacked evidence of a nonovarian primary mucinous tumor. All mucinous tumors were unilateral; 6 cases had bilateral teratomas. All tumors displayed gastrointestinal-type mucinous differentiation, with epithelium that was commonly goblet cell-rich or hypermucinous; 21 were associated with pseudomyxoma ovarii and 3 of these had pseudomyxoma peritonei. Tumor architecture ranged from purely cystadenomatous (n=24), to proliferative (n=13), to carcinomatous (n=6); some tumors had admixtures of these patterns. One tumor had a goblet cell carcinoidlike pattern with pseudomyxoma ovarii. Three carcinomas had a signet ring cell component. Cystadenomatous tumors without pseudomyxoma ovarii (n=15) exhibited all possible CK7/CK20 coordinate expression profiles with nearly equal frequency. All proliferative tumors without pseudomyxoma ovarii (n=8) expressed CK7, most often in combination with CK20 expression. All cystadenomatous and proliferative tumors with pseudomyxoma ovarii (n=9 and n=5) were CK7-/CK20+. All carcinomatous tumors had pseudomyxoma ovarii; 3 were CK7-/CK20+, 2 were CK7+/CK20+, and 1 was CK7+/CK20-. The presence of pseudomyxoma ovarii was significantly associated with a CK7-/CK20+ profile (86% with pseudomyxoma ovarii vs. 13% without, P<0.0001), CDX2 positivity (79% vs. 0%, P<0.0001), and villin positivity (57% vs. 5%, P=0.0009). A subset of mucinous tumors associated with mature cystic teratomas exhibiting morphologic and immunohistochemical features of lower intestinal tract-type mucinous tumors may be teratomatous in origin. In practice, the more common diagnosis of secondary involvement by a lower intestinal tract mucinous tumor should be addressed in the pathology report and in subsequent clinical evaluation; interpretation as a true primary ovarian mucinous tumor of teratomatous origin can be considered as an alternative diagnosis when evaluation and follow-up fail to identify a nonovarian source of the mucinous tumor. Those tumors having CK7 expression with or without CK20 expression may be derived from upper gastrointestinal tract-type or sinonasal-type teratomatous elements but could be independent tumors of surface epithelial-stromal origin.

show abstract

Endometrial Cyst, Dermoid Cyst and Mucinous Cystadenoma Sonographically Evidenced in the Same Ovary

Cited by 3 publications

References 7 publications

Mucinous cystadenoma arising 3 years after ovarian-sparing surgery for mature teratoma in a child

Mucinous cystadenoma arising 3 years after ovarian-sparing surgery for mature teratoma in a child

Germ cell tumors of the ovary: A clinicopathologic study of 121 cases from Nepal

Ovarian Mucinous Tumors Associated With Mature Cystic Teratomas

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