Endometrial extracellular vesicles of recurrent implantation failure patients inhibit the proliferation, migration, and invasion of HTR8/SVneo cells

Liu, Chang; Li, Linshuang; Wang, Meng; Shui, Shike; Yao, Haijun; Sui, Cong; Zhang, Hanwang

doi:10.1007/s10815-021-02093-5

Cited by 15 publications

(13 citation statements)

References 40 publications

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“…When I-EVs from RIF women were used for mouse embryo culture, but also weakened their invasion ability ( Liu et al, 2020a ). This could be because EM-EVs in RIF patients reduces trophoblast cell proliferation, migration, and invasion, resulting in implantation failure ( Liu et al, 2021 ). Furthermore, abnormal cytokine and leukocyte expression in endometritis may impair the endometrium’s immune tolerance to the embryo, which is not conducive to the invasion of the embryo’s survival trophoblast, leading to infertility, Recurrent spontaneous abortion (RSA) and RIF ( Buzzaccarini et al, 2020 ; Franasiak et al, 2021 ).…”

Section: The Role Of Evs In Embryo Implantationmentioning

confidence: 99%

Messenger roles of extracellular vesicles during fertilization of gametes, development and implantation: Recent advances

Fan

Wang

et al. 2023

Front. Cell Dev. Biol.

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Extracellular vesicles (EVs) have become a research hotspot in recent years because they act as messengers between cells in the physiological and pathological processes of the human body. It can be produced by the follicle, prostate, embryo, uterus, and oviduct in the reproductive field and exists in the extracellular environment as follicular fluid, semen, uterine cavity fluid, and oviduct fluid. Because extracellular vesicles are more stable at transmitting information, it allows all cells involved in the physiological processes of embryo formation, development, and implantation to communicate with one another. Extracellular vesicles carried miRNAs and proteins as mail, and when the messenger delivers the mail to the recipient cell, the recipient cell undergoes a series of changes. Current research begins with intercepting and decoding the information carried by extracellular vesicles. This information may help us gain a better understanding of the secrets of reproduction, as well as assist reproductive technology as an emerging marker and treatment.

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Section: The Role Of Evs In Embryo Implantationmentioning

confidence: 99%

Messenger roles of extracellular vesicles during fertilization of gametes, development and implantation: Recent advances

Fan

Wang

et al. 2023

Front. Cell Dev. Biol.

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“…The most active citer (49) in cluster #8 cited 11 member papers and reviewed endometrial factors, including CE, uterine peristalsis, and displacement of the WOI. Although extracellular vesicles have not been directly discussed, several studies show that extracellular vesicles in the normal endometria promote the proliferation of trophoblasts and may thus enhance the success of IVF (50)(51)(52). Therefore, alteration of the number of extracellular vesicles can prevent RIF.…”

Section: Intellectual Basementioning

confidence: 99%

Emerging trends and frontier research on recurrent implantation failure: a bibliometric analysis

Wang

Guan

et al. 2022

Ann Transl Med

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Background: Recurrent implantation failure (RIF) has been recognized to be a major obstacle to the successful application of artificial reproduction technologies. In this study, the trends in RIF research were examined through a bibliometric analysis evaluating relevant literature quantitatively and qualitatively.Methods: A total of 1,764 publications from 2000 to 2020 were downloaded from the Web of Science Core Collection (WoSCC). Relevant articles were searched using the term "recurrent implantation failure" and other synonyms of this term. Using Excel 2013, CiteSpace V, and VOSviewer 1.6.10 software, data extracted from the literature, including countries/regions, institutions, journals, keywords, and trends, were analyzed.Next, a clustered network was constructed based on 46,718 references cited by the 1,764 publications to determine the top 10 cocited articles. Results:The annual number of publications on RIF progressively increased over time. The highest number of publications were from the United States. Analysis of the cocited reference cluster showed that "endometrial injury", "platelet-rich plasma", "chronic endometritis" and "extracellular vesicles" were the hotspots in RIF research. Burst detection analysis of the top keywords showed that "hysteroscopy" and "improvement" are emerging research foci.Conclusions: This study clarifies the current research status and evolution of research in the field of RIF.New therapeutic interventions designed to improve pregnancy outcomes are the focus of current research and are expected to dominate future research in the field of RIF.

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“…It is widely accepted that women with a history of reproductive diseases such as recurrent implantation failure (RIF), polycystic ovary syndrome (PCOS), and endometriosis, are associated with future impaired embryo implantation (101)(102)(103)(104)(105). EVs-based intercellular communication plays an important role in female reproductive microenvironments and is involved in the pathogenesis of these disorders (59,89,(106)(107)(108)(109). The regulatory disorders caused by abnormal EVs may provide a new viewpoint of implantation failure in women with reproductive diseases (summarized in Table 3).…”

Section: Evs and Embryo Implantation: A New Viewpoint Of Reproductive Diseasesmentioning

confidence: 99%

“…The up-regulated miR-1246 and miR-1290 in the RIF-EVs may indicate the inadequate endometrial receptivity of RIF women (124). In vitro experimental studies have demonstrated that endometrial EVs from RIF women attenuate embryonic development and implantation capacity by inhibiting blastocyst formation, decreasing the total cell number of embryos as well as inhibiting the proliferation, migration, and invasion of trophoblast cells (59,109).…”

Section: Evs In Rifmentioning

confidence: 99%

The Complicated Effects of Extracellular Vesicles and Their Cargos on Embryo Implantation

Jiang

2021

Front. Endocrinol.

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As a rate-limiting step in pregnancy, embryo implantation is highly dependent on intercellular communication. Extracellular vesicles (EVs) are newly identified to be important in the course of intercellular communication. EVs have been isolated from a wide variety of biofluids and tissues, including plasma, liver, uterine, semen, embryo, etc. The present and future use of EVs not only as biomarkers, but also as targeting drug delivery system, is promisingly pave the way for advanced comprehension of implantation failure in reproductive diseases. However, as the precise mechanisms of EVs in embryo implantation has not been elucidated yet. Herein, we summarize the current knowledge on the diverse effects of EVs from various sources and their cargos such as microRNA, long non-coding RNA, protein, etc. on embryo implantation, and the potential mechanisms of EVs in reproductive diseases such as recurrent implantation failure, polycystic ovary syndrome and endometriosis. It is essential to note that many of the biologically plausible functions of EVs in embryo implantation discussed in present literatures still need further research in vivo.

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Endometrial extracellular vesicles of recurrent implantation failure patients inhibit the proliferation, migration, and invasion of HTR8/SVneo cells

Cited by 15 publications

References 40 publications

Messenger roles of extracellular vesicles during fertilization of gametes, development and implantation: Recent advances

Messenger roles of extracellular vesicles during fertilization of gametes, development and implantation: Recent advances

Emerging trends and frontier research on recurrent implantation failure: a bibliometric analysis

The Complicated Effects of Extracellular Vesicles and Their Cargos on Embryo Implantation

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