Endometrial gene expression in the early luteal phase is impacted by mode of triggering final oocyte maturation in recFSH stimulated and GnRH antagonist co-treated IVF cycles

Humaıdan, Peter; Vaerenbergh, Inge Van; Bourgain, Claire; Alsbjerg, Birgit; Blockeel, Christophe; Schuit, Frans; Lommel, Leentje Van; Devroey, Paul; Fatemi, Human M.

doi:10.1093/humrep/des279

Cited by 39 publications

(23 citation statements)

References 42 publications

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“…Both ploidy and age-related unique changes in human blastocysts microRNA profile have been reported recently [17]. The present hCG data were not adjusted for differences in stimulatory regimens used in the cycles, and hence it cannot be excluded that the observed effect is due to differences in COS which have been shown to influence the gene expression of the endometrium [18,19]. …”

Section: Discussionmentioning

confidence: 90%

Effect of women’s age on embryo morphology, cleavage rate and competence—A multicenter cohort study

et al. 2017

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This multicenter cohort study on embryo assessment and outcome data from 11,744 IVF/ICSI cycles with 104,830 oocytes and 42,074 embryos, presents the effect of women’s age on oocyte, zygote, embryo morphology and cleavage parameters, as well as cycle outcome measures corrected for confounding factors as center, partner’s age and referral diagnosis. Cycle outcome data confirmed the well-known effect of women’s age. Oocyte nuclear maturation and proportion of 2 pro-nuclear (2PN) zygotes were not affected by age, while a significant increase in 3PN zygotes was observed in both IVF and ICSI (p<0.0001) with increasing age. Maternal age had no effect on cleavage parameters or on the morphology of the embryo day 2 post insemination. Interestingly, initial hCG value after single embryo transfer followed by ongoing pregnancy was increased with age in both IVF (p = 0.007) and ICSI (p = 0.001) cycles. For the first time, we show that a woman’s age does impose a significant footprint on early embryo morphological development (3PN). In addition, the developmentally competent embryos were associated with increased initial hCG values as the age of the women increased. Further studies are needed to elucidate, if this increase in initial hCG value with advancing maternal age is connected to the embryo or the uterus.

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Section: Discussionmentioning

confidence: 90%

Effect of women’s age on embryo morphology, cleavage rate and competence—A multicenter cohort study

et al. 2017

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“…There is some evidence in both mice and humans to support differential endometrial gene expression based on the stimulation protocol used for superovulation, and this may influence placentation and growth (52, 53). Although changes in stimulation protocols may favorably alter endometrial gene expression, there is insufficient evidence currently to recommend an optimal regimen to maximize favorable endometrial gene expression profiles.…”

Section: Effects On the Endometriummentioning

confidence: 99%

“…Clinical studies have confirmed that elevated P before hCG administration is associated with decreased pregnancy rates in IVF, suggesting that an elevated P level does, in fact, shift the window of receptivity and reduce normal embryo implantation (38, 42). Supplementing P during the luteal phase alters endometrial gene expression, and luteal phase supplementation may be able to overcome some of the changes in endometrial receptivity induced by other aspects of superovulation (53, 78, 79). Although supplemental P is given to patients during both fresh and frozen embryo transfer cycles, the timing of P exposure differs in a fresh cycle, because the premature elevations in P often seen during stimulation in a fresh cycle do not occur in a frozen cycle.…”

Section: Potential Mediators Of These Effectsmentioning

confidence: 99%

Why we should transfer frozen instead of fresh embryos: the translational rationale

Weinerman

Mainigi

2014

Fertility and Sterility

157

105

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Epidemiologic studies have shown an increased rate of adverse perinatal outcomes, including small for gestational age (SGA) births, in fresh in vitro fertilization (IVF) cycles compared with frozen embryo transfer cycles. This increase is not seen in the donor oocyte population, suggesting that it is the peri-implantation environment created after superovulation that is responsible for these changes. During a fresh IVF cycle, multiple corpora lutea secrete high levels of hormones and other factors that can affect the endometrium and the implanting embryo. In this review, we discuss both animal and human data demonstrating that superovulation has significant effects on the endometrium and embryo. Additionally, potential mechanisms for the adverse effects of gonadotropin stimulation on implantation and placental development are proposed. We think that these data, along with the growing body of epidemiologic evidence, support the proposal that frozen embryo transfer should be considered preferentially, particularly in high responders, as a means to potentially decrease at least some of the adverse perinatal outcomes associated with IVF.

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“…A premature rise (>1.5 ng/mL) in progesterone may occur in spite of using GnRH agonist or antagonist for pituitary suppression during COS and is often associated with increased ovarian response (i.e., high estrogen levels and follicle numbers). Although the exact cause-andeffect mechanisms of a premature progesterone rise is not fully understood, it has been suggested to involve the advancement of endometrial development and in altered endometrial gene expression [7][8][9][10]. In some studies, cycles with elevated progesterone levels before ovulation induction have been associated with reduced pregnancy and live birth outcomes, suggestive of reduced endometrial receptivity and placentation [3,5].…”

Section: Introductionmentioning

confidence: 99%

Higher clinical pregnancy rates from frozen-thawed blastocyst transfers compared to fresh blastocyst transfers: a retrospective matched-cohort study

Özgür

Berkkanoğlu

Bulut

et al. 2015

J Assist Reprod Genet

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Purpose The purpose of this matched-cohort study was to assess endometrial receptivity to blastocyst implantation in fresh embryo transfer by comparing implantation outcomes of fresh embryo transfer with frozen embryo transfer, where two blastocysts of good quality were transferred in good prognosis patients. Method(s) Fresh embryo transfer from intracytoplasmic sperm injection cycles and artificial frozen embryo transfer cycles performed from January 2012 to December 2013 at a private clinic were retrospectively analyzed and the pregnancy, clinical pregnancy, and implantation rates statistically compared. Cycles were stratified and matched according to the blastocyst expansion grade (grade 2, 3, 4, or 5) of the two blastocysts transferred. Five hundred ninety-eight fresh embryo transfer cycles were matched with 545 frozen embryo transfer cycles across four blastocyst cohorts. Result(s) In this study of 1143 blastocyst transfer cycles, fresh embryo transfer resulted in reduced pregnancy, clinical pregnancy, and fetal heart implantation rates in all four blastocyst cohorts. The fetal heart implantation rates for fresh embryo transfer ranged from 16.7 % in the grade 2 to 47.3 % in the grade 5 cohort, compared to 23.1 % in the grade 2 to 57.4 % in the grade 5 cohort for frozen embryo transfer. The trends in increasing pregnancy outcomes relative to increasing blastocyst expansion were similar in fresh embryo transfer and frozen embryo transfer. Conclusion(s) Blastocysts of good quality transferred in frozen embryo transfer had a significantly greater chance of implantation and clinical pregnancy compared to blastocysts of matched quality transferred in fresh embryo transfer, suggesting reduced endometrial receptivity in fresh embryo transfer.

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Endometrial gene expression in the early luteal phase is impacted by mode of triggering final oocyte maturation in recFSH stimulated and GnRH antagonist co-treated IVF cycles

Abstract: EudraCT number 2009-009429-26, protocol number 997 (P06034).

Cited by 39 publications

References 42 publications

Effect of women’s age on embryo morphology, cleavage rate and competence—A multicenter cohort study

Effect of women’s age on embryo morphology, cleavage rate and competence—A multicenter cohort study

Why we should transfer frozen instead of fresh embryos: the translational rationale

Higher clinical pregnancy rates from frozen-thawed blastocyst transfers compared to fresh blastocyst transfers: a retrospective matched-cohort study

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