Endometrial histopathology patterns in women with abnormal uterine bleeding

Abstract

Background: Abnormal uterine bleeding is the most common gynaecological condition for which many women seek medical opinion. Evaluation of these women requires careful investigation into the cause and nature of bleeding with a main focus to exclude organic pathology, especially genital malignancies. Endometrial biopsy is one such intervention which is of immense value in categorizing the conditions. Aims and objectives of current study were to analyse endometrial histology patterns in women with AUB.Methods: This was a retrospective study conducted on women with AUB who presented in the gynae OPD during the study period of one year and had endometrial biopsy as part of evaluation. Women between with AUB were included in the study after excluding pregnancy related bleeding. Detailed clinical history, examination findings, investigations and endometrial histopathology was noted.Results: A total of 97 women with AUB who had undergone dilatation and curettage with endometrial biopsy were studied. Majority of women were in age group of 40-45 years and heavy menstrual bleeding was the commonest complaint, AUB (P) 17% and AUB (L) 39%, accounted for most of the clinical presentations. Endometrial histology showed varied patterns 27 % had secretory endometrium, 11% proliferative endometrium. There were 7 cases of endometrial hyperplasia without atypia and three cases of endometrial malignancy. Conclusions: Histopathological evaluation of endometrium is the cornerstone of management of abnormal uterine bleeding. Endometrial patterns obtained can be useful in ruling out malignancy and help in formulating further management.

Diagnostic value of endometrial samples in women with abnormal uterine bleeding at a teritiary care centre

“…A total of 360 cases of endometrial samples with a clinical diagnosis of AUB were analysed.In this study, AUB was commonly seen among perimenopausal age group(58.3%) which is in concordance with Rajani Vaidya et al, 1 Vijayaraghavan et al, 3 Jagadalekunda et al 5 Sajitha et al, 6 Sharma et al, 7 Khan et al 8 Majority of the cases of AUB were of multiparous women (57.8%) which is a similar finding in other studies. 3,[5][6][7][8][9][10][11][12][13][14] In the present study, high body mass index (BMI) was observed in women with hyperplasia and malignancy. Out of 94 cases of hyperplasia, 55 cases were overweight, 15 cases were obese.…”

“…3,[5][6][7][8][9][10][11][12][13] Functional causes (64.2%) of AUB are more common than organic causes (35.8%) in this study which is in concordance with study done by Sharma et al, 7 Vijayaraghavan et al, 3 Dwivedi et al, 9 Prathipa et al, 10 J Bindhuja et al, 12 Neha Khanam et al 15 Normal cyclical endometrium patterns are commonly seen in the present studywhich is similar to other studies. [3][4][5][6][7][8][9][10][11][12][13][14][15] Proliferative phase (34.7%) was the most common followed by secretory phase (18.9%) among all age groups of women in the present study.Similar findings were observed by Vijayaraghavan et al, 3 Jagadale Kunda et al, 5 Sharma et al 7 Disordered proliferative endometrium was seen in 5.83% of cases. Majority of the cases were in the age group of 18-40 years.…”