Endometrial injury in women undergoing assisted reproductive techniques

Nastri, C.O.; Lensen, Sarah; Gibreel, Ahmed; Raine‐Fenning, Nick; Ferriani, Rui Alberto; Bhattacharya, Siladitya; Martins, Wellington P.

doi:10.1002/14651858.cd009517.pub3

Cited by 133 publications

(44 citation statements)

References 34 publications

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“…We assumed that if hysteroscopy without biopsy has been found in some studies to lead to increased pregnancy rate, a less invasive procedure like intrauterine saline infusion, which has no adverse effects or does not require anesthesia, may improve implantation in IVF cycles as well ( 14 - 16 ). Contrary to previous results, our study showed that chemical and clinical pregnancy and implantation rates were significantly lower in intervention compared with control group ( 9 - 11 , 18 , 20 , 29 ).…”

Section: Discussioncontrasting

confidence: 99%

“…In a recent Cochrane's review by Nastri et al it was reported that EI in women undergoing ART between seven days of preceding cycle and the day of ET cycle versus no intervention was associated with increased live birth rate (LBR) in women with more than two previous embryo transfers. These researchers found no evidence regarding the effect of EI on miscarriage, multiple pregnancies or bleeding except mild pain ( 11 ). In another study, endometrial scratching by Pipple twice on day 21 or 22 immediately prior to IVF cycle, had similar LBR compared to the control group, but in a subgroup of patients with two or more previous IVF failures, it improved LBR.…”

Section: Discussionmentioning

confidence: 97%

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Does intrauterine saline infusion by intrauterine insemination (IUI) catheter as endometrial injury during IVF cycles improve pregnancy outcomes among patients with recurrent implantation failure?: An RCT

Salehpour

Zamaniyan

Saharkhiz

et al. 2016

IJRM

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Background:Recurrent implantation failure is one of the most issues in IVF cycles. Some researchers found that beneficial effects of endometrial Scratching in women with recurrent implantation failure, while some authors demonstrated contrary resultsObjective:The present study aimed to investigate the effect of intrauterine. Saline infusion as a form of endometrial injury, during fresh in vitro fertilization-embryo transfer cycle, among patients with recurrent implantation failure.Materials and Methods:In this clinical trial study 63 women undergoing assisted reproductive technology were divided into two groups either local endometrial injury by intrauterine saline infusion during day 3-5 of the ongoing controlled ovarian stimulation cycle, or IVF protocol performed without any other intervention in Taleghani Hospital, Tehran, Iran. The main outcome measure was clinical pregnancy rates.Results:Patients who received intra uterine saline infusion (n=20), had significantly lower clinical pregnancy numbers (1 vs. 9, p<0.05) and implantation rates (4.7% vs. 41.6%, p<0.05), compared to controls (n=39). However, there was no significant difference in miscarriage rates (9.4% vs. 8.7%, p>0.05) and multiple pregnancy numbers (1 vs. 3, p>0.05) between groups.Conclusion:When intrauterine saline infusion as a form of endometrial injury is performed during the ongoing IVF cycles it has negative effect on reproductive outcomes among patients with recurrent implantation failure.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Does intrauterine saline infusion by intrauterine insemination (IUI) catheter as endometrial injury during IVF cycles improve pregnancy outcomes among patients with recurrent implantation failure?: An RCT

Salehpour

Zamaniyan

Saharkhiz

et al. 2016

IJRM

View full text Add to dashboard Cite

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“…4,5 In the review of 14 studies, LEI was found to be related with an increase in clinical pregnancy rates in women who had two or more ET, while having no effect on incidence of twin pregnancy, miscarriage or bleeding. 15 In the current study, it was found that LEI increased implantation and clinical pregnancy rates in the patients who had their first IVF-ET cycle but this increase was not statistically significant.…”

Section: Discussioncontrasting

confidence: 51%

Is There any Impact of Local Endometrial Injury on Implantation and Clinical Pregnancy Rates in the First in Vitro Fertilization Cycles

Cüylan¹,

Demır²,

Dilbaz³

et al. 2019

JCOG

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mplantation is one of the most crucial steps for a successful in-vitro fertilization (IVF)-embryo transfer (ET). Implantation success depends on the quality of the embryo and endometrial receptivity. Even with a good quality embryo transfer, the rates of implantation may vary between 25-30% per transferred embryo. 1,2 Implantation occurs during the "implantation window", which is the period between the 19 th and 23 rd days of the menstrual cycle, when endometrial receptivity is at its peak, and includes a three-stage process of apposition, adhesion and invasion of the blastocyst to the endometrium.Recently, local endometrial injury (LEI) has been proposed as one of the methods that aim to increase the implantation rates in IVF-ET cycles. Initially, Barash et al. showed an increase in implantation and pregnancy rates in 134 women who had repeated endometrial biopsies as a method of LEI before IVF-ET cycles. 3 Likewise, other studies have also demonstrated an increase in pregnancy rates after LEI in women with recurrent IVF failure. 4,5 The first study investigating the effect of LEI on implantation and JCOG. 2019;29(4):129-35 129 A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To evaluate the impact of local endometrial injury (LEI), applied during the first in vitro fertilization (IVF)-embryo transfer (ET) cycle using office hysteroscopy, on implantation and pregnancy rates. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 372 women under the age of 40, who had their first IVF-ET treatment cycle, with no ovulatory or intracavitary pathology were included in this study. LEI was created in the fundus, anterior and posterior endometrial walls during office hysteroscopy, which was performed prior to the IVF-ET cycle. Long luteal gonadotropin releasing hormone agonist protocol was used in all cycles and 273 patients underwent embryo transfer. Implantation and pregnancy rates were compared to the control group. R Re es su ul lt ts s: : Age, body mass index, baseline follicle stimulating hormone, luteinizing hormone, and estradiol levels, antral follicle counts, infertility etiologies, total oocyte counts, intra-cytoplasmic sperm injection percentages were similar, both in the study and the control groups. Clinical pregnancy rates (28.7% vs 26.1%, p>0.05), total pregnancy rates (43.1% vs 38%, p>0.05) and implantation rates (19% vs 12.9%, p>0.05) of the LEI injury group were higher than those of the control group, however the difference was not statistically significant. There was no statistically significant difference between the miscarriage rates. C Co on nc cl lu us si io on n: : Even if implantation and pregnancy rates improved slightly in LEI group, the study did not reveal a significant improvement for the implantation and pregnancy rates after the LEI, which was created during hysteroscopy before the first IVF-RT treatment cycle. K Ke ey yw wo or rd ds s: : Embryo transfer; implantation; in vitro fertilization; local endometrial injury; office hysteroscopy

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“…This has been suggested to increase the likelihood of embryo implantation in the subsequent in vitro fertilisation treatment cycle. 26,27 Endometrial injury is not a routine step of outpatient hysteroscopy and could be performed without hysteroscopic guidance. It is plausible that the smaller diameter of the hysterocope used in our study (2•9mm), compared to the diameter of the hysterscopes used in previous studies (5mm), had caused less endometrial surface injury, resulting in a milder degree of endometrial stimulation for implantation.…”

Section: Discussionmentioning

confidence: 99%

Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY): a multicentre, randomised controlled trial

et al. 2016

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Endometrial injury in women undergoing assisted reproductive techniques

Cited by 133 publications

References 34 publications

Does intrauterine saline infusion by intrauterine insemination (IUI) catheter as endometrial injury during IVF cycles improve pregnancy outcomes among patients with recurrent implantation failure?: An RCT

Does intrauterine saline infusion by intrauterine insemination (IUI) catheter as endometrial injury during IVF cycles improve pregnancy outcomes among patients with recurrent implantation failure?: An RCT

Is There any Impact of Local Endometrial Injury on Implantation and Clinical Pregnancy Rates in the First in Vitro Fertilization Cycles

Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY): a multicentre, randomised controlled trial

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