Endometrial injury may promote implantation in patients with increased endometrial thickness on the day of hCG administration

Yoon, Jinyoung; Kim, Y.Y.; Kim, M.H.; Park, I.H.; Yoo, Yung-Choon; Jo, J.D.

doi:10.1016/j.fertnstert.2013.07.703

Cited by 2 publications

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“…Some studies have reported that no pregnancy occurs when endometrial thickness is less than 5 mm [ 30 ]. Additionally, when the endometrial thickness falls below 7 mm [ 31 , 32 ] or exceeds 16 mm, it is not conducive to embryo transfer and implantation, which results in a low clinical pregnancy rate [ 33 ]. Currently, endometrial thickness of more than 7 mm is considered the conventional lower limit for embryo transfer.…”

Section: Discussionmentioning

confidence: 99%

Clinical data-based modeling of IVF live birth outcome and its application

Liu,

Liang,

Yang

et al. 2024

Reprod Biol Endocrinol

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Background The low live birth rate and difficult decision-making of the in vitro fertilization (IVF) treatment regimen bring great trouble to patients and clinicians. Based on the retrospective clinical data of patients undergoing the IVF cycle, this study aims to establish classification models for predicting live birth outcome (LBO) with machine learning methods. Methods The historical data of a total of 1405 patients undergoing IVF cycle were first collected and then analyzed by univariate and multivariate analysis. The statistically significant factors were identified and taken as input to build the artificial neural network (ANN) model and supporting vector machine (SVM) model for predicting the LBO. By comparing the model performance, the one with better results was selected as the final prediction model and applied in real clinical applications. Results Univariate and multivariate analysis shows that 7 factors were closely related to the LBO (with P < 0.05): Age, ovarian sensitivity index (OSI), controlled ovarian stimulation (COS) treatment regimen, Gn starting dose, endometrial thickness on human chorionic gonadotrophin (HCG) day, Progesterone (P) value on HCG day, and embryo transfer strategy. By taking the 7 factors as input, the ANN-based and SVM-based LBO models were established, yielding good prediction performance. Compared with the ANN model, the SVM model performs much better and was selected as the final model for the LBO prediction. In real clinical applications, the proposed ANN-based LBO model can predict the LBO with good performance and recommend the embryo transfer strategy of potential good LBO. Conclusions The proposed model involving all essential IVF treatment factors can accurately predict LBO. It can provide objective and scientific assistance to clinicians for customizing the IVF treatment strategy like the embryo transfer strategy.

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Section: Discussionmentioning

confidence: 99%

Clinical data-based modeling of IVF live birth outcome and its application

Liu,

Liang,

Yang

et al. 2024

Reprod Biol Endocrinol

View full text Add to dashboard Cite

show abstract

“…The normal endometrial stages include proliferation, secretion, and menstrual periods, and thus the thickness of the endometrium changes over the course of the menstrual cycle. Most researchers consider that if the endometrium is extremely thin (<8 mm), this might cause unfavorable condition for embryo implantation and thus result in a low clinical pregnancy rate, and extreme thickness (>16 mm) might also reduce the clinical pregnancy rate [ 34 ]. Accordingly, as indicated from the results presented here, CAM therapy (including CAM therapies used alone as well as CAM therapies used in combination with traditional western medicine) is capable of effectively reducing the thickness of the endometrium in pathological hyperplasia, while in PCOS patients with infertility it can increase the thickness of the endometrium during ovulation thereby improving the status of the endometrium, increasing the pregnancy rate, and decreasing the abortion rate.…”

Section: Discussionmentioning

confidence: 99%

Complementary and Alternative Medicine for the Treatment of Abnormal Endometrial Conditions in Women with PCOS: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Shi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Endometrial lesions in patients with polycystic ovary syndrome (PCOS) exhibit complex pathological features, and these patients are at risk of both short-term and long-term complications. Complementary and alternative medicine (CAM), which is gradually becoming more accepted and is believed to be clinically effective, claims to be promising for treating PCOS, and thus its effect on the abnormal endometrium of PCOS patients should be assessed. The present meta-analysis sought to evaluate the efficacy and safety of CAM in treating endometrial lesions in patients with PCOS. Methods. Randomized trials on CAM were identified in four Chinese and seven English-language databases from their establishment to January 2020. The present study included patients diagnosed with PCOS and abnormal endometrial conditions who underwent CAM therapy independently or in combination with traditional western medicine. Data were extracted, and the Cochrane “risk of bias” tool was used to assess methodological quality. Effects were expressed as the relative risk (RR) or mean difference (MD/SMD) with 95% confidence interval (CI) as calculated with Rev Man 5.3. Results. A total of 13 randomized controlled trials were included, involving 1,297 PCOS patients treated for endometrial abnormalities. Methodological quality was generally unclear or had a low risk of bias. The trials tested four different types of CAM therapies (i.e., traditional Chinese medicine treatment, acupuncture treatment, traditional Chinese medicine in combination with western medicine treatment, and acupuncture in combination with western medicine treatment). CAM treatment could significantly reduce the endometrial thickness in PCOS patients compared to western medicine alone (SMD −0.88, 95% CI [−0.12, −0.57]; I2 = 64%). Compared with clomiphene treatment for the induction of ovulation, CAM treatment showed a clear improvement in endometrial thickness during ovulation (SMD 2.03, 95% CI [1.64, 2.02]; I2 = 48%). Moreover, CAM was more effective than western medicine alone in reducing the endometrial spiral artery pulsatility index. No significant difference was seen between CAM and traditional treatment when these were used to improve traditional Chinese medicine syndrome scores. Acupuncture alone or traditional Chinese medicines (taken orally) in combination with western medicine significantly increased the pregnancy rate of PCOS patients (RR 1.59, 95% CI [1.30, 1.93]; I2 = 51%, P < 0.00001 ), and CAM was more effective than western medicine alone for improving hormone levels. No serious adverse events were reported in 11 of the 13 trials. Conclusions. CAM may effectively ameliorate the endometrial condition of PCOS patients, and it can regulate the level of hormone secretion to increase the ovulation rate and the pregnancy rate.

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Endometrial injury may promote implantation in patients with increased endometrial thickness on the day of hCG administration

Cited by 2 publications

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Clinical data-based modeling of IVF live birth outcome and its application

Clinical data-based modeling of IVF live birth outcome and its application

Complementary and Alternative Medicine for the Treatment of Abnormal Endometrial Conditions in Women with PCOS: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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