Endometrial L-selectin ligand is downregulated in the mid-secretory phase during the menstrual cycle in women with adenomyosis

Lai, Tsung‐Ching; Lin, Junjie; Ling, Qing-Dong

doi:10.1016/j.tjog.2018.06.005

Cited by 8 publications

(5 citation statements)

References 36 publications

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“…The role of the integrin family of cell adhesion receptors is related to the cell to cell interactions that occur between the conceptus and the endometrium that involve the ECM. Also reported are increased levels of b-catenin (66) and L-selectin (67), proteins that in part are involved with regulation of cell to cell adhesion. The normal elevations of integrin beta-3 and osteopontin are reduced in women with adenomyosis (68), and lower serum osteopontin levels have been reported in women with ''focal'' disease (69).…”

Section: Adenomyosismentioning

confidence: 99%

Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity

Munro

2019

Fertility and Sterility

161

103

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Endometrial polyps, adenomyosis, and leiomyomas are commonly encountered abnormalities frequently found in both fertile women and those with infertility. The clinician is frequently challenged to determine which of these entities, when found, is likely to impair fertility, and which are ''innocent bystanders'' unrelated to the problem at hand. Although removing an endometrial polyp may be seen as a relatively benign and safe intervention, myomectomy, and in particular adenomyomectomy, can be substantive surgical procedures, associated with their own potential for disrupting fertility. One of the mechanisms thought to be involved when these entities are contributing to infertility is an adverse impact on endometrial receptivity. Indeed polyps, adenomyosis, and leiomyomas have all been associated with an increased likelihood of abnormal endometrial molecular expressions thought to impair implantation and early embryo development. This review is designed to examine the relationship of these common entities to endometrial receptivity and to identify evidence gaps that should be considered when strategizing research initiatives. It is apparent that we have the tools necessary to fill these gaps, but it will be necessary to approach the issue in a strategic and coordinated fashion. It is likely that we will have to recognize the limitations of imaging alone and look to the evidence-based addition of molecular analysis to provide the individualized phenotyping of disease necessary for patient-specific treatment decisions. (Fertil Steril Ò 2019;111:629-40. Ó2019 by American Society for Reproductive Medicine.

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Section: Adenomyosismentioning

confidence: 99%

Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity

Munro

2019

Fertility and Sterility

161

103

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“…gov/pubmed/) (Table II). In comparison with the genetic and proteomic data previously published for adenomyosis and (13,30), L-selectin ligand (31) and Annexin A2 (ANXA2) (32)(33)(34)(35), were considered to be target genes for adenomyosis. These previous studies revealed that, among these, 4 genes (IGF1, KISS1, NCAM1 and ANXA2) were upregulated, and 3 genes (OPN, VCAN and L-selectin ligand) were downregulated.…”

Section: Differentially Expressed Genes and Their Functions Between Amentioning

confidence: 99%

“…L-selectins induce the integrin β2-dependent tyrosine phosphorylation of multiple proteins, resulting in the enhancement of target cell adhesion, slow rolling and recruitment. The expression of L-selectin ligands is increased in endometriosis, but decreased in adenomyosis (31). Aberrant adhesion represents an acquired advantage of tumor cells directly responsible for an invasive phenotype, which is considered to be a hallmark of cancer progression.…”

Section: Functional Pathways Of Adenomyosis Candidate Genesmentioning

confidence: 99%

“…A reduced expression of adhesion molecules may contribute to an enhanced invasive phenotype of adenomyotic cells. However, constitutive defects in L-selectin ligand expression may be attributed to poor uterine receptivity and cause implantation failure (31). Future studies are required to focus on the mechanisms through which L-selectin ligands affect adenomyotic cell adhesion, migration and invasion.…”

Section: Functional Pathways Of Adenomyosis Candidate Genesmentioning

confidence: 99%

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Bioinformatics strategy for the screening of key genes to differentiate adenomyosis from endometriosis (Review)

2019

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“…Naturally, the endometrium is tightly controlled by the orchestration of female sex hormones to complete its cyclic change, which is initiated in the proliferative phase and transforms into the secretory phase. All are for the preparation for embryo implantation, and this period of endometrial change is especially critical, often called uterine receptivity [ 11 , 12 , 13 ]. Endometrial tissue destruction (menstrual breakdown) and re-epithelialization (repair) occur simultaneously [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision

Lee

Liu

Chen

et al. 2021

IJMS

107

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Intrauterine adhesion (IUA), and its severe form Asherman syndrome (Asherman’s syndrome), is a mysterious disease, often accompanied with severe clinical problems contributing to a significant impairment of reproductive function, such as menstrual disturbance (amenorrhea), infertility or recurrent pregnancy loss. Among these, its correlated infertility may be one of the most challenging problems. Although there are many etiologies for the development of IUA, uterine instrumentation is the main cause of IUA. Additionally, more complicated intrauterine surgeries can be performed by advanced technology, further increasing the risk of IUA. Strategies attempting to minimize the risk and reducing its severity are urgently needed. The current review will expand the level of our knowledge required to face the troublesome disease of IUA. It is separated into six sections, addressing the introduction of the normal cyclic endometrial repairing process and its abruption causing the formation of IUA; the etiology and prevalence of IUA; the diagnosis of IUA; the classification of IUA; the pathophysiology of IUA; and the primary prevention of IUA, including (1) delicate surgical techniques, such as the use of surgical instruments, energy systems, and pre-hysteroscopic management, (2) barrier methods, such as gels, intrauterine devices, intrauterine balloons, as well as membrane structures containing hyaluronate–carboxymethylcellulose or polyethylene oxide–sodium carboxymethylcellulose as anti-adhesive barrier.

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Endometrial L-selectin ligand is downregulated in the mid-secretory phase during the menstrual cycle in women with adenomyosis

Cited by 8 publications

References 36 publications

Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity

Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity

Bioinformatics strategy for the screening of key genes to differentiate adenomyosis from endometriosis (Review)

Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision

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