Endometrial Metastasis from Ductal Breast Carcinoma: A Case Report with Literature Review

Abstract

Patient: Female, 51Final Diagnosis: Endometrial metastasis from ductal breast carcinonomaSymptoms: Abnormal uterine bleeding • menorrhagiaMedication: —Clinical Procedure: Dilatation and curettage (D&C) • tissue diagnosis of the endometriumSpecialty: Obstetrics and GynecologyObjective:Unusual clinical courseBackground:There are few reports of breast cancer cases with uterine metastases; among them, myometrium is more frequently involved than endometrium. The majority of breast cancer metastases to endometrium are lobular type, and there have been only 5 reported cases of ductal type since 1984. Here, we describe a new case of invasive ductal carcinoma with metastases to endometrium and isolated presentation of abnormal uterine bleeding, in addition to reviewing the existing literature on other similar cases.Case Report:The patient was a 51-year-old Persian woman with no remarkable past medical or family history of cancer, who presented with a 6-month complaint of menorrhagia to our gynecology clinic. Diagnostic studies including trans-vaginal ultrasonography, pathological examination of endometrial curettage specimen, immunohistochemistry findings, and X-plane and magnetic resonance mammography, and breast core-needle biopsy revealed invasive ductal breast carcinoma as the origin of the endometrial metastasis.Conclusions:Abnormal uterine bleeding in a premenopausal patient should alert clinicians to the possibility of secondary as well as primary neoplasms. It is necessary to differentiate a metastatic tumor from a primary one, since the treatment and prognosis are completely different.

Uterine Metastases in a Diagnosed Case of Invasive Ductal Breast Carcinoma: A Rare Presentation

“…Isolated uterine metastases are caused by hematogenous spread [4]. Endometrial involvement can be asymptomatic or present as abnormal uterine bleeding, as in our case [5].…”

Synchronous primary malignancy of breast and endometrium in premenopausal women - A rare case report

“…Many risk factors contribute to Endometrial & Breast Carcinoma, and some of them are shared. The risk factors can be genetic susceptibility, hormonal, environmental, or other treatment-related factors, obesity, or the interaction of several unknown factors (Rahmani, 2018). Some of them are controversial, e.g., high BMI is shown to be directly associated with the risks of Breast Carcinoma in postmenopausal women; however, it has an opposite effect on premenopausal women.…”

An Unusual Occurrence of Uterine Metastases in a Case of Invasive Ductal Breast Carcinoma

“…Isolated uterine metastases are caused by hematogeneous spread [ 5 ]. Endometrial involvement can be asymptomatic or present as abnormal uterine bleeding (AUB), as in our case [ 6 ].…”