Endometrial Morphology and Peripheral Hormone Levels in Women with Regular Menstrual Cycles

Johannisson, E.; Landgren, Britt-Marie; Rohr, H. P.; Diczfalusy, E.

doi:10.1097/00006254-198804000-00017

Cited by 20 publications

(30 citation statements)

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“…However, some authors have reported that numbers of endometrial glands do not change during the natural cycle (Johannisson et al 1987, 1991, Wahab et al 1999.…”

Section: Discussionmentioning

confidence: 99%

“…When assessing endometrial morphology, gland duct number has most frequently been used to quantify changes for diagnostic purposes or following clinical treatments in both humans and farm animals (Gonzalez et al 1985, Johannisson et al 1987, Wahab et al 1999, Gray et al 2001, Carpenter et al 2003. However, some authors have reported that numbers of endometrial glands do not change during the natural cycle (Johannisson et al 1987, 1991, Wahab et al 1999.…”

Section: Discussionmentioning

confidence: 99%

“…Recent developments in morphometrics have made the quantification of cyclic changes in endometrium feasible, and using these methods, it has been possible to identify the morphological changes occurring during the follicular and luteal phases in the human and ruminant uterus (Wahab et al 1999, Dhaliwal et al 2002. Furthermore, in human endometrium, glandular diameter during the proliferative and secretory phases has been correlated with oestrogen and progesterone levels (Johannisson et al 1987). More recently in ruminants, morphometry has also been applied to the analysis of gland morphogenesis in animals depleted of uterine glands (Gray et al 2001, Carpenter et al 2003.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative analysis of changes in endometrial gland morphology during the bovine oestrous cycle and their association with progesterone levels

Wang¹,

Robinson²,

Flint³

et al. 2007

Reproduction

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This study describes a digital technique for uterine morphometry and its application to endometrial structure during the bovine oestrous cycle. Neither the number nor the size of uterine gland ducts changed during the cycle but a reduction in total endometrial area from days 0 to 8 after oestrus led to an increase in the proportion of the endometrium occupied by gland ducts (gland duct density). This effect on day 8 was maintained to day 16. When endometrial morphology was related to circulating progesterone concentrations on days 5 and 8 of the luteal phase, no relationships were found on day 5, but on day 8, a high progesterone concentration was associated with an increased number of gland ducts. Furthermore, in animals slaughtered on day 8, a high progesterone concentration on day 5 was associated with decreased gland duct size, though a simultaneous decrease in endometrial area led to an increase in gland duct density. The results suggest that contrary to expectation, endometrial glands do not grow and regress during the oestrous cycle, although cyclic changes in endometrial area controlled by progesterone lead to changes in gland duct density.

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“…However, some authors have reported that numbers of endometrial glands do not change during the natural cycle (Johannisson et al 1987, 1991, Wahab et al 1999.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative analysis of changes in endometrial gland morphology during the bovine oestrous cycle and their association with progesterone levels

Wang¹,

Robinson²,

Flint³

et al. 2007

Reproduction

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“…It was proposed that the dating of endometrium should be related to the serum LH surge, which corresponds to ovulation, rather than to the "ideal" 28-day cycle [28]. Endometrial histology is most consistent in biopsies from days LH −3/−2 to days LH +7/+8, when changes occur with a high degree of regularity regardless of the length of the preovulatory and postovulatory phases [28]. It is now a common practice to date endometrium according to days after the LH peak [29] [30].…”

Section: Endometrial Dating and The Window Of Implantationmentioning

confidence: 99%

“…Recently, on a large number of women, it was demonstrated that histological dating of the endometrium does not have the accuracy or the precision necessary for the diagnosis of luteal phase deficiency, or to guide clinical management of women with reproductive failure [26,27]. It was proposed that the dating of endometrium should be related to the serum LH surge, which corresponds to ovulation, rather than to the "ideal" 28-day cycle [28]. Endometrial histology is most consistent in biopsies from days LH −3/−2 to days LH +7/+8, when changes occur with a high degree of regularity regardless of the length of the preovulatory and postovulatory phases [28].…”

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confidence: 99%

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Aghajanova¹,

Hamilton²,

Giudice³

2008

Seminars in Cell & Developmental Biology

140

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Embryonic implantation is a dynamic process of paracrine interactions between the maternal compartment and the conceptus and involves a receptive endometrium and a developmentally competent blastocyst. Herein, we review histology, clinical approaches, and the promise of transcriptomics in elucidating mechanisms underlying implantation and development of biomarkers of uterine receptivity -with an eye to diagnose and treat implantation-based disorders of miscarriage, fetal growth restriction, pre-eclampsia, and infertility.Keywords human implantation; endometrium; microarray; blastocyst Challenges and approaches in studying the process of human implantation Clinical implicationsSuccessful embryo implantation is a crucial event in natural and assisted human reproduction. Blastocyst implantation is a dynamic process, involving embryo apposition, attachment to the maternal endometrial epithelium, and invasion into the endometrial stroma [1]. With in vitro fertilization (IVF), implantation failure can occur due to several factors [2], including embryonic defects such as chromosomal abnormalities, which are the most common cause of implantation failure [3,4]. Another widely acknowledged barrier to successful blastocyst implantation and, therefore, successful treatment of infertile women with implantation failure, is an inappropriately developed endometrium. It is well established that embryos cannot implant in a poorly matured endometrium [5], and this may be responsible for low implantation rates with transfer of "good quality" embryos. The success of embryonic implantation further relies upon cross-talk between the embryo and a receptive endometrium [5]. Optimization of IVF results are important for many reasons, and achieving optimal implantation is even more important in the setting of single embryo transfer, a common practice aimed to avoid multiple pregnancies.Corresponding author: Linda C. Giudice, MD, PhD, MSc, Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences, The Robert B. Jaffe, MD Endowed Professor in the Reproductive Sciences, University of California, San Francisco, 505 Parnassus Ave., M1496, Box 0132, San Francisco, CA 94143-0132, Tel: +1 4154762564, Fax: +1 415476181, giudice@obgyn.ucsf.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The implantation window and challenges of studying it NIH Public AccessThe endometrium is receptive to blastocyst implantation during a spatially and temporally restricted "window", when the luminal epithelium is favorable for blastocyst implantation even in the absence of an implanting ...

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Cell kinetic study of the endometrium by nonisotopic in situ hybridization for histone H3 messenger RNA and immunohistochemistry for Ki‐67 and for estrogen and progesterone receptors

et al. 2002

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We investigated the cell kinetics of the endometrium in hysterectomy specimens taken for leiomyoma from 22 women with regular ovulatory menstrual cycles. Formalin-fixed, paraffin-embedded tissue sections were examined for proliferating activity using histone H3 messenger RNA in situ hybridization (H3 mRNA-ISH) and immunostaining for the Ki-67 antigen. The relationship of the proliferative activity of endometrial cells to the immunohistochemical expression of the estrogen receptor (ER) and the progesterone receptor (PR) was also examined. During the menstrual cycle, H3 mRNA expression was observed in both the epithelial cells and the stromal cells of the endometrium. In the functional layer, the labeling indices for H3 mRNA (H3 mRNA-LIs) in the epithelial cells peaked in the late proliferative phase, decreased sharply in the early secretory phase, and remained unchanged thereafter. On the other hand, H3 mRNA-LIs of stromal cells displayed two peaks: one in the midproliferative phase and the other in the late secretory phase, the former peak being the greater. In the basal layer, epithelial cells and stromal cells showed low H3 mRNA-LIs and no significant variation throughout the menstrual cycle. The H3 mRNA-LIs correlated well with the Ki-67-LIs and were lower than the corresponding Ki-67-LIs. The regression coefficient (H3 mRNA-LIs against the Ki-67-LIs) was 0.33 for epithelial cells and 0.49 for stromal cells, suggesting that the cell cycle time was longer for epithelial cells than for stromal cells. The proliferative activity of endometrial cells showed close relationships with the expressions of ER and PR in the endometrium. When used in combination with other proliferative markers in paraffin-embedded tissue sections, H3 mRNA-ISH could open broader perspectives on the cell kinetics of the endometrium. Anat Rec 266: 234 -240, 2002.

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Endometrial Morphology and Peripheral Hormone Levels in Women with Regular Menstrual Cycles

Cited by 20 publications

References 0 publications

Quantitative analysis of changes in endometrial gland morphology during the bovine oestrous cycle and their association with progesterone levels

Quantitative analysis of changes in endometrial gland morphology during the bovine oestrous cycle and their association with progesterone levels

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Cell kinetic study of the endometrium by nonisotopic in situ hybridization for histone H3 messenger RNA and immunohistochemistry for Ki‐67 and for estrogen and progesterone receptors

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